دورية أكاديمية
أعرض في EDS

Effect of orbital decompression surgery on the choroidal profile in patients with thyroid eye disease.

التفاصيل البيبلوغرافية
العنوان: Effect of orbital decompression surgery on the choroidal profile in patients with thyroid eye disease.
المؤلفون: Rafizadeh SM; Department of Orbital and Oculoplastic Surgery, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran., Momeni A; Department of Orbital and Oculoplastic Surgery, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran., Rahimi M; Retina Service, Farabi Eye Hospital, Tehran University of Medical Sciences, South Kargar Street, Qazvin Square, Tehran, Iran., Riazi-Esfahani H; Retina Service, Farabi Eye Hospital, Tehran University of Medical Sciences, South Kargar Street, Qazvin Square, Tehran, Iran. Hamidriazi@gmail.com., Yaseri M; Department of Biostatistics and Epidemiology, Tehran University of Medical Sciences, Tehran, Iran., Ghanbari H; Department of Orbital and Oculoplastic Surgery, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran., Khalili Pour E; Retina Service, Farabi Eye Hospital, Tehran University of Medical Sciences, South Kargar Street, Qazvin Square, Tehran, Iran.
المصدر: Scientific reports [Sci Rep] 2024 Jun 28; Vol. 14 (1), pp. 14948. Date of Electronic Publication: 2024 Jun 28.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Decompression, Surgical*/methods , Graves Ophthalmopathy*/surgery , Graves Ophthalmopathy*/diagnostic imaging , Choroid*/diagnostic imaging , Choroid*/surgery , Choroid*/pathology , Tomography, Optical Coherence*/methods , Orbit*/surgery , Orbit*/diagnostic imaging, Humans ; Female ; Male ; Middle Aged ; Adult ; Exophthalmos/surgery ; Exophthalmos/diagnostic imaging ; Aged ; Treatment Outcome
مستخلص: This study aimed to investigate the effect of orbital wall decompression surgery and reduction of proptosis on the choroidal vascularity index (CVI) and subfoveal choroidal thickness (SFCT) in patients with thyroid eye disease (TED). Fifty-one eyes from 38 patients with controlled TED and proptosis were enrolled in this study. The majority of the patients (50.9%) had a clinical activity score (CAS) of zero, and none had a CAS greater than 2. The patients underwent a complete baseline ophthalmologic examination, and their choroidal profile alterations were monitored using enhanced depth imaging optical coherence tomography (EDI-OCT) before and during the three months after surgery. Changes in SFCT, luminance area (LA), total choroidal area (TCA), and the choroidal vascularity index (CVI) were measured as the ratio of LA to TCA in EDI-OCT images. The participants had an average age of 46.47 years, and 22 were female (57.9%). The SFCT of the patients exhibited a significant reduction over the follow-up period, decreasing from 388 ± 103 to 355 ± 95 µm in the first month (p < 0.001) and further decreasing to 342 ± 109 µm by the third month compared to baseline (p < 0.001). The CVI exhibited a drop from 0.685 ± 0.037 at baseline to 0.682 ± 0.035 and 0.675 ± 0.030 at 1 and 3 months post-surgery, respectively. However, these changes were not statistically significant, indicating comparable decreases in both LA and TCA. There was a significant correlation between improved proptosis and reduction in SFCT (p < 0.001) but not with CVI (p = 0.171). In conclusion, during the three months of follow-up following orbital wall decompression, CVI did not change, while SFCT reduced significantly. Additionally, SFCT was significantly correlated with proptosis reduction, whereas CVI was not.
(© 2024. The Author(s).)
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فهرسة مساهمة: Keywords: Choroid vascularity index (CVI); Choroidal thickness; Orbital decompression; Thyroid eye disease (TED)
تواريخ الأحداث: Date Created: 20240628 Date Completed: 20240628 Latest Revision: 20240701
رمز التحديث: 20240701
مُعرف محوري في PubMed: PMC11213849
DOI: 10.1038/s41598-024-65884-7
PMID: 38942805
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-024-65884-7