دورية أكاديمية
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Hyaluronic Acid-Modified Spherical MgO 2 /Pd Nanocomposites Exhibit Superior Antitumor Effect through Tumor Microenvironment-Responsive Ferroptosis Induction and Photothermal Therapy.

التفاصيل البيبلوغرافية
العنوان: Hyaluronic Acid-Modified Spherical MgO 2 /Pd Nanocomposites Exhibit Superior Antitumor Effect through Tumor Microenvironment-Responsive Ferroptosis Induction and Photothermal Therapy.
المؤلفون: Xie W; Henan Joint International Research Laboratory of Stem Cell Medicine, College of Medical Engineering, Xinxiang Medical University, Xinxiang 453003, China., Lu Y; Stem Cell and Biotherapy Technology Research Center, College of Life Science and Technology, Xinxiang Medical University, Xinxiang 453003, China., Yuan Y; Henan Joint International Research Laboratory of Stem Cell Medicine, College of Medical Engineering, Xinxiang Medical University, Xinxiang 453003, China., Xiao L; Stem Cell and Biotherapy Technology Research Center, College of Life Science and Technology, Xinxiang Medical University, Xinxiang 453003, China., Liu J; Henan Joint International Research Laboratory of Stem Cell Medicine, College of Medical Engineering, Xinxiang Medical University, Xinxiang 453003, China., Song H; Stem Cell and Biotherapy Technology Research Center, College of Life Science and Technology, Xinxiang Medical University, Xinxiang 453003, China., Niu R; Stem Cell and Biotherapy Technology Research Center, College of Life Science and Technology, Xinxiang Medical University, Xinxiang 453003, China., Liu Y; Stem Cell and Biotherapy Technology Research Center, College of Life Science and Technology, Xinxiang Medical University, Xinxiang 453003, China., Lin J; Henan Joint International Research Laboratory of Stem Cell Medicine, College of Medical Engineering, Xinxiang Medical University, Xinxiang 453003, China.; Stem Cell and Biotherapy Technology Research Center, College of Life Science and Technology, Xinxiang Medical University, Xinxiang 453003, China.
المصدر: ACS biomaterials science & engineering [ACS Biomater Sci Eng] 2024 Aug 12; Vol. 10 (8), pp. 5226-5236. Date of Electronic Publication: 2024 Jun 29.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101654670 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-9878 (Electronic) Linking ISSN: 23739878 NLM ISO Abbreviation: ACS Biomater Sci Eng Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, DC : American Chemical Society, [2015]-
مواضيع طبية MeSH: Hyaluronic Acid*/chemistry , Hyaluronic Acid*/pharmacology , Ferroptosis*/drug effects , Tumor Microenvironment*/drug effects , Magnesium Oxide*/chemistry , Magnesium Oxide*/pharmacology , Nanocomposites*/chemistry , Nanocomposites*/therapeutic use , Photothermal Therapy*/methods , Palladium*/chemistry , Palladium*/pharmacology , Palladium*/therapeutic use, Animals ; Humans ; Mice ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/therapeutic use ; Cell Line, Tumor ; Hydrogen Peroxide
مستخلص: Metal peroxide nanomaterials as efficient hydrogen peroxide (H 2 O 2 ) self-supplying agents have attracted the attention of researchers for antitumor treatment. However, relying solely on metal peroxides to provide H 2 O 2 is undoubtedly insufficient to achieve optimal antitumor effects. Herein, we construct novel hyaluronic acid (HA)-modified nanocomposites (MgO 2 /Pd@HA NCs) formed by decorating palladium nanoparticles (Pd NPs) onto the surfaces of a magnesium peroxide (MgO 2 ) nanoflower as a highly effective nanoplatform for the tumor microenvironment (TME)-responsive induction of ferroptosis in tumor cells and tumor photothermal therapy (PTT). MgO 2 /Pd@HA NC could be well endocytosed into tumor cells with CD44 expression depending on the specific recognition of HA with CD44, and then, the nanocomposites can be rapidly decomposed in mild acid and hyaluronidase overexpressed TME, and plenty of H 2 O 2 was released. Simultaneously, Pd NPs catalyze self-supplied H 2 O 2 to generate abundant hydroxyl radicals ( • OH) and catalyze glutathione (GSH) into glutathione disulfide owing to its peroxidase and glutathione oxidase mimic enzyme activities, while the abundant • OH could also consume GSH in tumor cells and disturb the defense pathways of ferroptosis leading to the accumulation of lipid peroxidation and resulting in the occurrence of ferroptosis. Additionally, the superior photothermal conversion performance of Pd NPs in near-infrared II could also be used for PTT, synergistically cooperating with nanocomposite-induced ferroptosis for tumor inhibition. Consequently, the successfully prepared TME-responsive MgO 2 /Pd@HA NCs exhibited marked antitumor effect without obvious biotoxicity, contributing to thoroughly explore the nanocomposites as a novel and promising treatment for tumor therapy.
فهرسة مساهمة: Keywords: ferroptosis; nanocomposites; nanozymes; photothermal therapy; tumor microenvironment-responsive
المشرفين على المادة: 9004-61-9 (Hyaluronic Acid)
3A3U0GI71G (Magnesium Oxide)
5TWQ1V240M (Palladium)
0 (Antineoplastic Agents)
BBX060AN9V (Hydrogen Peroxide)
تواريخ الأحداث: Date Created: 20240629 Date Completed: 20240812 Latest Revision: 20240812
رمز التحديث: 20240813
DOI: 10.1021/acsbiomaterials.4c00555
PMID: 38943566
قاعدة البيانات: MEDLINE
الوصف
تدمد:2373-9878
DOI:10.1021/acsbiomaterials.4c00555