دورية أكاديمية
[Relationships between Cxcl12, Tweak, Notch1, and Yap mRNA Expression Levels in Molecular Mechanisms of Liver Fibrogenesis].
| العنوان: | [Relationships between Cxcl12, Tweak, Notch1, and Yap mRNA Expression Levels in Molecular Mechanisms of Liver Fibrogenesis]. |
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| المؤلفون: | Lebedeva EI; Vitebsk State Order of Peoples' Friendship Medical University, Vitebsk, 210009 Belarus.; lebedeva.ya-elenale2013@yandex.ru., Shchastniy AT; Vitebsk State Order of Peoples' Friendship Medical University, Vitebsk, 210009 Belarus., Babenka AS; Belarussian State Medical University, Minsk, 220116 Belarus., Zinovkin DA; Gomel State Medical University, Gomel, 246050 Belarus. |
| المصدر: | Molekuliarnaia biologiia [Mol Biol (Mosk)] 2024 Jan-Feb; Vol. 58 (1), pp. 130-140. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Izdatelstvo Nauka Country of Publication: Russia (Federation) NLM ID: 0105454 Publication Model: Print Cited Medium: Print ISSN: 0026-8984 (Print) Linking ISSN: 00268984 NLM ISO Abbreviation: Mol Biol (Mosk) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Moskva : Izdatelstvo Nauka |
| مواضيع طبية MeSH: | YAP-Signaling Proteins*/genetics , YAP-Signaling Proteins*/metabolism , Rats, Wistar* , Receptor, Notch1*/genetics , Receptor, Notch1*/metabolism , RNA, Messenger*/genetics , RNA, Messenger*/metabolism , Chemokine CXCL12*/genetics , Chemokine CXCL12*/metabolism , Cytokine TWEAK*/genetics , Cytokine TWEAK*/metabolism, Animals ; Rats ; Male ; Matrix Metalloproteinase 9/genetics ; Matrix Metalloproteinase 9/metabolism ; Gene Expression Regulation ; Liver Cirrhosis/genetics ; Liver Cirrhosis/metabolism ; Liver Cirrhosis/pathology ; Liver Cirrhosis/chemically induced ; Thioacetamide/toxicity ; Receptor, Notch2/genetics ; Receptor, Notch2/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Nitric Oxide Synthase Type II/genetics ; Nitric Oxide Synthase Type II/metabolism |
| مستخلص: | Current data on the molecular mechanisms of liver fibrosis and cirrhosis fail to fully explain all stages of their development. Interactions between individual genes and signaling pathways are known to play an important role in their functions. However, data on their relationships are insufficient and often contradictory. For the first time, mRNA expression of Notch1, Notch2, Yap1, Tweak (Tnfsf12), Fn14 (Tnfrsf12a), Ang, Vegfa, Cxcl12 (Sdf), Nos2, and Mmp-9 was studied in detail at several stages of thioacetamide-induced liver fibrosis in Wistar rats. A factor analysis isolated three factors, which combined highly correlated target genes. The first factor included four genes: Cxcl12 (r = 0.829, p < 0.05), Tweak (r = 0.841, p < 0.05), Notch1 (r = 0.848, p < 0.05), and Yap1 (r = 0.921, p < 0.05). The second factor described the correlation between Mmp-9 (r = 0.791, p < 0.05) and Notch2 (r = 0.836, p < 0.05). The third factor included Ang (r = 0.748, p < 0.05) and Vegfa (r = 0.679, p < 0.05). The Nos2 and Fn14 genes were not included in any of the factors. The gene grouping by mRNA expression levels made it possible to assume a pathogenetic relationship between their products in the development of fibrotic changes due to liver toxicity. |
| فهرسة مساهمة: | Keywords: factor analysis; liver cirrhosis; liver fibrosis; mRNA expression; molecular mechanisms; rats |
| المشرفين على المادة: | 0 (YAP-Signaling Proteins) 0 (Yap1 protein, rat) 0 (Receptor, Notch1) 0 (RNA, Messenger) 0 (Chemokine CXCL12) 0 (Cytokine TWEAK) 0 (Notch1 protein, rat) EC 3.4.24.35 (Matrix Metalloproteinase 9) 075T165X8M (Thioacetamide) 0 (Receptor, Notch2) 0 (Transcription Factors) EC 1.14.13.39 (Nos2 protein, rat) EC 1.14.13.39 (Nitric Oxide Synthase Type II) EC 3.4.24.35 (Mmp9 protein, rat) |
| تواريخ الأحداث: | Date Created: 20240629 Date Completed: 20240629 Latest Revision: 20240629 |
| رمز التحديث: | 20240630 |
| DOI: | 10.31857/S0026898424010126, EDN: NXGUNP |
| PMID: | 38943584 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0026-8984 |
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| DOI: | 10.31857/S0026898424010126, EDN: NXGUNP |