دورية أكاديمية
أعرض في EDS

Prussian blue-decorated indocyanine green-loaded mesoporous silica nanohybrid for synergistic photothermal-photodynamic-chemodynamic therapy against methicillin-resistant Staphylococcus aureus.

التفاصيل البيبلوغرافية
العنوان: Prussian blue-decorated indocyanine green-loaded mesoporous silica nanohybrid for synergistic photothermal-photodynamic-chemodynamic therapy against methicillin-resistant Staphylococcus aureus.
المؤلفون: Qi C; State Key Laboratory of Advanced Technology for Material Synthesis and Processing, Biomedical Materials and Engineering Research Center of Hubei Province, Wuhan University of Technology, Wuhan 430070, China., Tan G; State Key Laboratory of Advanced Technology for Material Synthesis and Processing, Biomedical Materials and Engineering Research Center of Hubei Province, Wuhan University of Technology, Wuhan 430070, China., Hu H; State Key Laboratory of Advanced Technology for Material Synthesis and Processing, Biomedical Materials and Engineering Research Center of Hubei Province, Wuhan University of Technology, Wuhan 430070, China., Zhang Y; State Key Laboratory of Advanced Technology for Material Synthesis and Processing, Biomedical Materials and Engineering Research Center of Hubei Province, Wuhan University of Technology, Wuhan 430070, China., Chen J; State Key Laboratory of Advanced Technology for Material Synthesis and Processing, Biomedical Materials and Engineering Research Center of Hubei Province, Wuhan University of Technology, Wuhan 430070, China., Zhang Q; State Key Laboratory of Advanced Technology for Material Synthesis and Processing, Biomedical Materials and Engineering Research Center of Hubei Province, Wuhan University of Technology, Wuhan 430070, China., Tu J; State Key Laboratory of Advanced Technology for Material Synthesis and Processing, Biomedical Materials and Engineering Research Center of Hubei Province, Wuhan University of Technology, Wuhan 430070, China. Electronic address: tujing@whut.edu.cn.
المصدر: Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2024 Sep; Vol. 241, pp. 114065. Date of Electronic Publication: 2024 Jun 27.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9315133 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4367 (Electronic) Linking ISSN: 09277765 NLM ISO Abbreviation: Colloids Surf B Biointerfaces Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam ; New York : Elsevier, c1993-
مواضيع طبية MeSH: Methicillin-Resistant Staphylococcus aureus*/drug effects , Indocyanine Green*/chemistry , Indocyanine Green*/pharmacology , Silicon Dioxide*/chemistry , Silicon Dioxide*/pharmacology , Ferrocyanides*/chemistry , Ferrocyanides*/pharmacology , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry , Photochemotherapy*, Porosity ; Microbial Sensitivity Tests ; Photothermal Therapy ; Nanoparticles/chemistry ; Surface Properties ; Particle Size ; Photosensitizing Agents/pharmacology ; Photosensitizing Agents/chemistry ; Hydrogen Peroxide/pharmacology ; Hydrogen Peroxide/chemistry ; Nanocomposites/chemistry ; Infrared Rays ; Humans ; Animals
مستخلص: Nanomaterial-based synergistic antibacterial agents are considered as promising tools to combat infections caused by antibiotic-resistant bacteria. Herein, multifunctional mesoporous silica nanoparticle (MSN)-based nanocomposites were fabricated for synergistic photothermal/photodynamic/chemodynamic therapy against methicillin-resistant Staphylococcus aureus (MRSA). MSN loaded with indocyanine green (ICG) as a core, while Prussian blue (PB) nanostructure was decorated on MSN surface via in situ growth method to form a core-shell nanohybrid (MSN-ICG@PB). Upon a near infrared (NIR) laser excitation, MSN-ICG@PB (200 μg mL -1 ) exhibited highly efficient singlet oxygen ( 1 O 2 ) generation and hyperthermia effect (48.7℃). In the presence of exogenous H 2 O 2 , PB with peroxidase-like activity promoted the generation of toxic hydroxyl radicals (•OH) to achieve chemodynamic therapy (CDT). PTT can greatly increase the permeability of bacterial lipid membrane, facilitating the generated 1 O 2 and •OH to kill bacteria more efficiently. Under NIR irradiation and exogenous H 2 O 2 , MSN-ICG@PB (200 μg mL -1 ) with good biocompatibility exhibited a synergistic antibacterial effect against MRSA with high bacterial killing efficiency (>98 %). Moreover, due to the synergistic bactericidal mechanism, MSN-ICG@PB with satisfactory biosafety makes it a promising antimicrobial agent to fight against MRSA.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Conflicts of interest There are no conflicts to declare.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Methicillin-resistant Staphylococcus aureus; Photodynamic therapy; Photothermal therapy; Triple-mode synergistic therapy
المشرفين على المادة: IX6J1063HV (Indocyanine Green)
7631-86-9 (Silicon Dioxide)
TLE294X33A (ferric ferrocyanide)
0 (Ferrocyanides)
0 (Anti-Bacterial Agents)
0 (Photosensitizing Agents)
BBX060AN9V (Hydrogen Peroxide)
تواريخ الأحداث: Date Created: 20240629 Date Completed: 20240727 Latest Revision: 20240727
رمز التحديث: 20240729
DOI: 10.1016/j.colsurfb.2024.114065
PMID: 38943768
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-4367
DOI:10.1016/j.colsurfb.2024.114065