دورية أكاديمية
A broadly generalizable stabilization strategy for sarbecovirus fusion machinery vaccines.
| العنوان: | A broadly generalizable stabilization strategy for sarbecovirus fusion machinery vaccines. |
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| المؤلفون: | Lee J; Department of Biochemistry, University of Washington, Seattle, Washington, USA., Stewart C; Department of Biochemistry, University of Washington, Seattle, Washington, USA., Schäfer A; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA., Leaf EM; Department of Biochemistry, University of Washington, Seattle, Washington, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Park YJ; Department of Biochemistry, University of Washington, Seattle, Washington, USA.; Howard Hughes Medical Institute, Seattle, WA, USA., Asarnow D; Department of Biochemistry, University of Washington, Seattle, Washington, USA., Powers JM; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA., Treichel C; Department of Biochemistry, University of Washington, Seattle, Washington, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Sprouse KR; Department of Biochemistry, University of Washington, Seattle, Washington, USA.; Howard Hughes Medical Institute, Seattle, WA, USA., Corti D; Humabs Biomed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland., Baric R; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA., King NP; Department of Biochemistry, University of Washington, Seattle, Washington, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Veesler D; Department of Biochemistry, University of Washington, Seattle, Washington, USA. dveesler@uw.edu.; Howard Hughes Medical Institute, Seattle, WA, USA. dveesler@uw.edu. |
| المصدر: | Nature communications [Nat Commun] 2024 Jun 28; Vol. 15 (1), pp. 5496. Date of Electronic Publication: 2024 Jun 28. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [London] : Nature Pub. Group |
| مواضيع طبية MeSH: | Antibodies, Neutralizing*/immunology , Antibodies, Viral*/immunology , Spike Glycoprotein, Coronavirus*/immunology , SARS-CoV-2*/immunology , COVID-19*/prevention & control , COVID-19*/immunology , COVID-19*/virology, Animals ; Mice ; Humans ; Female ; COVID-19 Vaccines/immunology ; COVID-19 Vaccines/administration & dosage ; Mice, Inbred BALB C |
| مستخلص: | Evolution of SARS-CoV-2 alters the antigenicity of the immunodominant spike (S) receptor-binding domain and N-terminal domain, undermining the efficacy of vaccines and antibody therapies. To overcome this challenge, we set out to develop a vaccine focusing antibody responses on the highly conserved but metastable S (© 2024. The Author(s).) |
| التعليقات: | Update of: bioRxiv. 2023 Dec 20:2023.12.12.571160. doi: 10.1101/2023.12.12.571160. (PMID: 38168207) |
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| معلومات مُعتمدة: | 75N93022C00036 United States AI NIAID NIH HHS; DP1 AI158186 United States AI NIAID NIH HHS; P01 AI167966 United States AI NIAID NIH HHS |
| المشرفين على المادة: | 0 (Antibodies, Neutralizing) 0 (Antibodies, Viral) 0 (Spike Glycoprotein, Coronavirus) 0 (COVID-19 Vaccines) 0 (spike protein, SARS-CoV-2) |
| تواريخ الأحداث: | Date Created: 20240629 Date Completed: 20240629 Latest Revision: 20240708 |
| رمز التحديث: | 20240708 |
| مُعرف محوري في PubMed: | PMC11214633 |
| DOI: | 10.1038/s41467-024-49656-5 |
| PMID: | 38944664 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 2041-1723 |
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| DOI: | 10.1038/s41467-024-49656-5 |