دورية أكاديمية
Behavioral Dysfunctions Caused by Pyridoxamine Deficiency in Drosophila melanogaster.
| العنوان: | Behavioral Dysfunctions Caused by Pyridoxamine Deficiency in Drosophila melanogaster. |
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| المؤلفون: | Ueno K; Learning and Memory Project, Tokyo Metropolitan Institute of Medical Science., Nohara I; Schizophrenia Research Project, Tokyo Metropolitan Institute of Medical Science., Miyashita M; Schizophrenia Research Project, Tokyo Metropolitan Institute of Medical Science., Itokawa M; Schizophrenia Research Project, Tokyo Metropolitan Institute of Medical Science., Okado H; Brain Development and Neural Regeneration Project, Tokyo Metropolitan Institute of Medical Science., Arai M; Schizophrenia Research Project, Tokyo Metropolitan Institute of Medical Science., Saitoe M; Learning and Memory Project, Tokyo Metropolitan Institute of Medical Science. |
| المصدر: | Journal of nutritional science and vitaminology [J Nutr Sci Vitaminol (Tokyo)] 2024; Vol. 70 (3), pp. 252-261. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: University of Tokyo Press Country of Publication: Japan NLM ID: 0402640 Publication Model: Print Cited Medium: Internet ISSN: 1881-7742 (Electronic) Linking ISSN: 03014800 NLM ISO Abbreviation: J Nutr Sci Vitaminol (Tokyo) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Tokyo, University of Tokyo Press. |
| مواضيع طبية MeSH: | Drosophila melanogaster* , Glycation End Products, Advanced*/metabolism , Pyridoxamine*/pharmacology , Behavior, Animal* , Longevity*, Animals ; Male ; Sleep/physiology ; Female ; Sexual Behavior, Animal/physiology ; Sexual Behavior, Animal/drug effects ; Learning |
| مستخلص: | Pyridoxamine (PM) is one of the natural vitamins B6 (VB6) and functions as an endogenous inhibitor for the formation of AGEs (advanced glycation end products). The AGEs are implicated in aging, diabetes, and various neuropsychiatric disease, including schizophrenia, Alzheimer's disease, and Parkinson's disease. However, it is unclear whether the absence of PM per se accumulates AGEs in vivo and causes behavioral dysfunctions. To address these points, we raised PM-deficient fruit flies, Drosophila melanogaster, with the sterilized defined medium. Flies reared in a PM-deficient medium accumulated AGEs and reduced lifespan, impaired gustatory response, sleep, courtship behavior, and olfactory learning. These results suggest that PM suppresses AGE accumulation in vivo and is required for regulating innate and empirical behaviors. |
| فهرسة مساهمة: | Keywords: Drosophila; behavior; pentosidine; pyridoxamine; vitamin B6 |
| المشرفين على المادة: | 0 (Glycation End Products, Advanced) 6466NM3W93 (Pyridoxamine) |
| تواريخ الأحداث: | Date Created: 20240630 Date Completed: 20240630 Latest Revision: 20240630 |
| رمز التحديث: | 20240701 |
| DOI: | 10.3177/jnsv.70.252 |
| PMID: | 38945891 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1881-7742 |
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| DOI: | 10.3177/jnsv.70.252 |