دورية أكاديمية
أعرض في EDS

MgSiO 3 Fiber Membrane Scaffold with Triggered Drug Delivery for Osteosarcoma Synergetic Therapy and Bone Regeneration.

التفاصيل البيبلوغرافية
العنوان: MgSiO 3 Fiber Membrane Scaffold with Triggered Drug Delivery for Osteosarcoma Synergetic Therapy and Bone Regeneration.
المؤلفون: Mao J; Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education), Shandong University, Jinan 250061, P. R. China.; Schools of Materials Science and Engineering, Shandong University, Jinan 250061, P. R. China., Bi J; Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education), Shandong University, Jinan 250061, P. R. China.; Schools of Materials Science and Engineering, Shandong University, Jinan 250061, P. R. China., Sun Z; Department of Orthopaedics, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P. R. China.; The First Clinical Medical School, Shandong University, Jinan, Shandong 250012, P. R. China., Wang L; Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education), Shandong University, Jinan 250061, P. R. China.; Schools of Materials Science and Engineering, Shandong University, Jinan 250061, P. R. China.
المصدر: ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2024 Jul 10; Vol. 16 (27), pp. 34669-34683. Date of Electronic Publication: 2024 Jun 30.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101504991 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1944-8252 (Electronic) Linking ISSN: 19448244 NLM ISO Abbreviation: ACS Appl Mater Interfaces Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, D.C. : American Chemical Society
مواضيع طبية MeSH: Doxorubicin*/chemistry , Doxorubicin*/pharmacology , Osteosarcoma*/drug therapy , Osteosarcoma*/pathology , Bone Regeneration*/drug effects , Indocyanine Green*/chemistry , Indocyanine Green*/pharmacology, Animals ; Humans ; Mice ; Magnesium Silicates/chemistry ; Photothermal Therapy ; Cell Line, Tumor ; Drug Delivery Systems ; Bone Neoplasms/drug therapy ; Bone Neoplasms/pathology ; Drug Liberation
مستخلص: In this research, a novel MgSiO 3 fiber membrane (MSFM) loaded with indocyanine green (ICG) and doxorubicin (DOX) was prepared. Because of MgSiO 3 's unique lamellar structure composed of a silicon-oxygen tetrahedron, magnesium ion (Mg 2+ ) moves easily and can be further replaced with other cations. Therefore, because of the positively charged functional group of ICG, MSFM has a rather high drug loading for ICG. In addition, there is electrostatic attraction between DOX (a cationic drug) and ICG (an anionic drug). Hence, after loading ICG, more DOX can be adsorbed into MSFM because of electrostatic interaction. The ICG endows the MSFM outstanding photothermal therapy (PTT) performance, and DOX as a chemotherapeutic drug can restrain tumor growth. On the one hand, H + exchanged with the positively charged DOX based on the MgSiO 3 special lamellar structure. On the other hand, the thermal effect could break the electrostatic interaction between ICG and DOX. Based on the above two points, both tumor acidic microenvironment and photothermal effect can trigger DOX release. What's more, in vitro and in vivo antiosteosarcoma therapy evaluations displayed a superior synergetic PTT-chemotherapy anticancer treatment and excellent biocompatibility of DOX&ICG-MSFM. Finally, the MSFM was proven to greatly promote cell proliferation, differentiation, and bone regeneration performance in vitro and in vivo. Therefore, MSFM provides a creative perspective in the design of multifunctional scaffolds and shows promising applications in controlled drug delivery, antitumor performance, and osteogenesis.
فهرسة مساهمة: Keywords: MgSiO3 fiber membrane; antitumor; controlled drug delivery; osteogenesis; photothermal therapy; synergetic treatment
المشرفين على المادة: 80168379AG (Doxorubicin)
IX6J1063HV (Indocyanine Green)
0 (Magnesium Silicates)
تواريخ الأحداث: Date Created: 20240701 Date Completed: 20240711 Latest Revision: 20240711
رمز التحديث: 20240711
DOI: 10.1021/acsami.4c05744
PMID: 38946103
قاعدة البيانات: MEDLINE
الوصف
تدمد:1944-8252
DOI:10.1021/acsami.4c05744