دورية أكاديمية
Cancer to Cataracts: The Mechanistic Impact of Aldo-Keto Reductases in Chronic Diseases.
العنوان: | Cancer to Cataracts: The Mechanistic Impact of Aldo-Keto Reductases in Chronic Diseases. |
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المؤلفون: | Shanbhag AP; Bugworks Research India Pvt. Ltd., Bengaluru, Karnataka, India.; Novartis Healthcare Pvt. Ltd., Hyderabad, Telangana, India., Bhowmik P; Bugworks Research India Pvt. Ltd., Bengaluru, Karnataka, India.; Centre for Cellular and Molecular Platforms (C-CAMP), National Centre for Biological Sciences (NCBS), Bengaluru, Karnataka, India. |
المصدر: | The Yale journal of biology and medicine [Yale J Biol Med] 2024 Jun 28; Vol. 97 (2), pp. 179-204. Date of Electronic Publication: 2024 Jun 28 (Print Publication: 2024). |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Yale Journal of Biology and Medicine Country of Publication: United States NLM ID: 0417414 Publication Model: eCollection Cited Medium: Internet ISSN: 1551-4056 (Electronic) Linking ISSN: 00440086 NLM ISO Abbreviation: Yale J Biol Med Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: New Haven, CT : Yale Journal of Biology and Medicine |
مواضيع طبية MeSH: | Aldo-Keto Reductases*/metabolism , Aldo-Keto Reductases*/genetics , Cataract*/enzymology , Cataract*/genetics , Cataract*/metabolism , Neoplasms*/enzymology , Neoplasms*/genetics, Humans ; Chronic Disease |
مستخلص: | Aldo-keto reductases (AKRs) are a superfamily of promiscuous enzymes that have been chiseled by evolution to act as catalysts for numerous regulatory pathways in humans. However, they have not lost their promiscuity in the process, essentially making them a double-edged sword. The superfamily is involved in multiple metabolic pathways and are linked to chronic diseases such as cataracts, diabetes, and various cancers. Unlike other detoxifying enzymes such as cytochrome P450s (CYP450s), short-chain dehydrogenases (SDRs), and medium-chain dehydrogenases (MDRs), that participate in essential pathways, AKRs are more widely distributed and have members with interchangeable functions. Moreover, their promiscuity is ubiquitous across all species and participates in the resistance of pathogenic microbes. Moreover, the introduction of synthetic substrates, such as synthetic molecules and processed foods, results in unwanted "toxification" due to enzyme promiscuity, leading to chronic diseases. (Copyright ©2024, Yale Journal of Biology and Medicine.) |
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فهرسة مساهمة: | Keywords: Alcoholic Liver disease; Aldo-keto reductases; Cancers; Promiscuity; Steroid synthesis |
المشرفين على المادة: | EC 1.1.1.- (Aldo-Keto Reductases) |
تواريخ الأحداث: | Date Created: 20240701 Date Completed: 20240701 Latest Revision: 20240702 |
رمز التحديث: | 20240702 |
مُعرف محوري في PubMed: | PMC11202113 |
DOI: | 10.59249/VTBV6559 |
PMID: | 38947111 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1551-4056 |
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DOI: | 10.59249/VTBV6559 |