In-hospital outcomes in COVID-19 patients with non-alcoholic fatty liver disease by severity of obesity: Insights from national inpatient sample 2020.

التفاصيل البيبلوغرافية
العنوان:	In-hospital outcomes in COVID-19 patients with non-alcoholic fatty liver disease by severity of obesity: Insights from national inpatient sample 2020.
المؤلفون:	Srikanth S; Department of Medicine, ECU Health Medical Center, Greenville, NC 27834, United States., Garg V; Department of Medicine, Jacobi Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, United States., Subramanian L; Department of Medicine, ECU Health Medical Center, Greenville, NC 27834, United States., Verma J; Department of Medicine, North Alabama Medical Centre, Florence, AL 35630, United States., Sharma H; Department of General Medicine, Gandhi Medical College, Secunderabad 500003, Telangana, India., Klair HS; Department of Medicine, Government Medical College, Patiala 147001, Punjab, India., Kavathia SA; Department of Medicine, B.J. Medical College, Ahmedabad 380016, Gujarat, India., Teja JK; Department of Medicine, JSS Medical College, Mysore 570015, Karnataka, India., Vasireddy NS; Department of Internal Medicine, Gandhi Medical College, Secunderabad 500003, Telangana, India., Anmol K; Department of Medicine, Kasturba Medical College, Manipal 575001, Karnataka, India., Kolli D; Department of Medicine, Kasturba Medical College, Manipal 575001, Karnataka, India., Bodhankar SS; Department of Medicine, Government Medical College, Patiala 147001, Punjab, India., Hashmi S; Clinical Extern, Department of Internal Medicine, Beaumont Hospital, Dearborn, MI 48124, United States., Chauhan S; Department of Internal Medicine, Geisinger Health System, Wilkes-Barre, PA 18702, United States. drshaylikachauhan@gmail.com., Desai R; Independent Researcher, Atlanta, GA 30079, United States.
المصدر:	World journal of hepatology [World J Hepatol] 2024 Jun 27; Vol. 16 (6), pp. 912-919.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Baishideng Publishing Group Country of Publication: United States NLM ID: 101532469 Publication Model: Print Cited Medium: Print ISSN: 1948-5182 (Print) NLM ISO Abbreviation: World J Hepatol Subsets: PubMed not MEDLINE
أسماء مطبوعة:	Publication: 2014- : Pleasanton, CA : Baishideng Publishing Group Original Publication: Beijing, China : Baishideng
مستخلص:	Background: Non-alcoholic fatty liver disease (NAFLD) increases the risk of cardiovascular diseases independently of other risk factors. However, data on its effect on cardiovascular outcomes in coronavirus disease 2019 (COVID-19) hospitalizations with varied obesity levels is scarce. Clinical management and patient care depend on understanding COVID-19 admission results in NAFLD patients with varying obesity levels. Aim: To study the in-hospital outcomes in COVID-19 patients with NAFLD by severity of obesity. Methods: COVID-19 hospitalizations with NAFLD were identified using International Classification of Disease -10 CM codes in the 2020 National Inpatient Sample database. Overweight and Obesity Classes I, II, and III (body mass index 30-40) were compared. Major adverse cardiac and cerebrovascular events (MACCE) (all-cause mortality, acute myocardial infarction, cardiac arrest, and stroke) were compared between groups. Multivariable regression analyses adjusted for sociodemographic, hospitalization features, and comorbidities. Results: Our analysis comprised 13260 hospitalizations, 7.3% of which were overweight, 24.3% Class I, 24.1% Class II, and 44.3% Class III. Class III obesity includes younger patients, blacks, females, diabetics, and hypertensive patients. On multivariable logistic analysis, Class III obese patients had higher risks of MACCE, inpatient mortality, and respiratory failure than Class I obese patients. Class II obesity showed increased risks of MACCE, inpatient mortality, and respiratory failure than Class I, but not significantly. All obesity classes had non-significant risks of MACCE, inpatient mortality, and respiratory failure compared to the overweight group. Conclusion: Class III obese NAFLD COVID-19 patients had a greater risk of adverse outcomes than class I. Using the overweight group as the reference, unfavorable outcomes were not significantly different. Morbid obesity had a greater risk of MACCE regardless of the referent group (overweight or Class I obese) compared to overweight NAFLD patients admitted with COVID-19. Competing Interests: Conflict-of-interest statement: All authors have no conflict of interest related to the manuscript. (©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.)
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فهرسة مساهمة:	Keywords: Acute myocardial infarction; Body mass index; Cardiac arrest; Major adverse cardiac and cerebrovascular events; Mortality; Non-alcoholic fatty liver disease; Obese; Obesity; Stroke
تواريخ الأحداث:	Date Created: 20240701 Latest Revision: 20240702
رمز التحديث:	20240702
مُعرف محوري في PubMed:	PMC11212648
DOI:	10.4254/wjh.v16.i6.912
PMID:	38948433
قاعدة البيانات:	MEDLINE

الوصف
تدمد:	1948-5182
DOI:	10.4254/wjh.v16.i6.912