Effect of acidic vaginal pH on the efficacy of dinoprostone (PGE 2 ) vaginal tablet for labor induction in full term pregnant women: a randomized controlled trial.

التفاصيل البيبلوغرافية
العنوان:	Effect of acidic vaginal pH on the efficacy of dinoprostone (PGE 2 ) vaginal tablet for labor induction in full term pregnant women: a randomized controlled trial.
المؤلفون:	Panagiotopoulos M; Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Athens, Greece., Pergialiotis V; Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Athens, Greece., Antsaklis P; Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Athens, Greece., Theodora M; Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Athens, Greece., Sindos M; Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Athens, Greece., Daskalaki MA; Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Athens, Greece., Koutroumanis P; Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Athens, Greece., Daskalakis G; Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Athens, Greece.
المصدر:	Journal of perinatal medicine [J Perinat Med] 2024 Jul 02. Date of Electronic Publication: 2024 Jul 02.
Publication Model:	Ahead of Print
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Walter De Gruyter Country of Publication: Germany NLM ID: 0361031 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1619-3997 (Electronic) Linking ISSN: 03005577 NLM ISO Abbreviation: J Perinat Med Subsets: MEDLINE
أسماء مطبوعة:	Publication: Berlin : Walter De Gruyter Original Publication: Berlin, New York, Walter de Gruyter.
مستخلص:	Objectives: There is controversial evidence that acidification of vaginal pH may increase the efficacy of vaginal prostaglandins in labor induction, with research being mainly focused on misoprostol. This study aims to evaluate the impact of this intervention on the progress of labor induction with dinoprostone (PGE2) vaginal tablet. Methods: This double-blind, parallel-group, randomized study was conducted between October 2021 and December 2022 at Alexandra General Hospital, Athens, Greece. A total of 230 women with singleton, full term pregnancy that were scheduled for labor induction were randomly divided into two groups: Group A, who received acidic vaginal wash (5 % acetic acid) and Group B, who received a normal saline vaginal wash. Afterwards, participants received a vaginal tablet of 3 mg dinoprostone every 6 h (maximum two doses). Results: There were no statistically significant differences in mode of delivery, duration of different labor stages, Bishop score changes and possible complications. Participants in the acidification group needed less often labor augmentation with oxytocin and epidural anesthesia (p=0.03). Conclusions: Vaginal acidification seems to have no effect on the efficacy of the dinoprostone vaginal tablet. Even though it may reduce the need for oxytocin augmentation, there is no apparent benefit on clinical outcomes, such as reduction in cesarean section rates or shorter labor duration. Future research is necessary in order to validate these findings. (© 2024 the author(s), published by De Gruyter, Berlin/Boston.)
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فهرسة مساهمة:	Keywords: acetic acid; dinoprostone; labor induction; randomized controlled trial; vaginal acidification
تواريخ الأحداث:	Date Created: 20240701 Latest Revision: 20240701
رمز التحديث:	20240701
DOI:	10.1515/jpm-2024-0176
PMID:	38949076
قاعدة البيانات:	MEDLINE

الوصف
تدمد:	1619-3997
DOI:	10.1515/jpm-2024-0176