دورية أكاديمية
أعرض في EDS

Functional autoantibodies against G protein-coupled receptors in hepatic and pulmonary hypertensions in human schistosomiasis.

التفاصيل البيبلوغرافية
العنوان: Functional autoantibodies against G protein-coupled receptors in hepatic and pulmonary hypertensions in human schistosomiasis.
المؤلفون: Botoni FA; Postgraduate Program in Infectiology and Tropical Medicine, School of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.; Internal Medicine Department, School of Medicine Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.; Fundação Hospitalar do Estado de Minas Gerais - FHEMIG, Belo Horizonte, Brazil., Lambertucci JR; Postgraduate Program in Infectiology and Tropical Medicine, School of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.; Internal Medicine Department, School of Medicine Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.; Postgraduate Program in Health and Nutrition, School of Nutrition, Universidade Federal de Ouro Preto, Ouro Preto, Brazil., Santos RAS; Department of Physiology and Biophysics of the Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Müller J; Berlin Cures GmbH, Berlin, Germany., Talvani A; Postgraduate Program in Infectiology and Tropical Medicine, School of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.; Postgraduate Program in Health and Nutrition, School of Nutrition, Universidade Federal de Ouro Preto, Ouro Preto, Brazil.; Department of Biological Sciences, Universidade Federal Ouro Preto, Ouro Preto, Brazil., Wallukat G; Berlin Cures GmbH, Berlin, Germany.; Max-Delbrück Centrum für Molekulare Medizin, Berlin, Germany.
المصدر: Frontiers in immunology [Front Immunol] 2024 Jun 17; Vol. 15, pp. 1404384. Date of Electronic Publication: 2024 Jun 17 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Lausanne : Frontiers Research Foundation]
مواضيع طبية MeSH: Autoantibodies*/immunology , Autoantibodies*/blood , Receptors, G-Protein-Coupled*/immunology , Receptors, G-Protein-Coupled*/metabolism, Humans ; Animals ; Rats ; Male ; Female ; Adult ; Hypertension, Pulmonary/immunology ; Hypertension, Pulmonary/etiology ; Middle Aged ; Myocytes, Cardiac/immunology ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/parasitology ; Schistosomiasis mansoni/immunology ; Schistosoma mansoni/immunology ; Schistosomiasis/immunology
مستخلص: Introduction: Schistosomiasis (SM) is a parasitic disease caused by Schistosoma mansoni . SM causes chronic inflammation induced by parasitic eggs, with collagen/fibrosis deposition in the granuloma process in the liver, spleen, central nervous system, kidneys, and lungs. Pulmonary arterial hypertension (PAH) is a clinical manifestation characterized by high pressure in the pulmonary circulation and right ventricular overload. This study investigated the production of functional autoantibodies (fAABs) against the second loop of the G-protein-coupled receptor (GPCR) in the presence of hepatic and PAH forms of human SM.
Methods: Uninfected and infected individuals presenting acute and chronic manifestations (e.g., hepatointestinal, hepato-splenic without PAH, and hepato-splenic with PAH) of SM were clinically evaluated and their blood was collected to identify fAABs/GPCRs capable of recognizing endothelin 1, angiotensin II, and a-1 adrenergic receptor. Human serum was analyzed in rat cardiomyocytes cultured in the presence of the receptor antagonists urapidil, losartan, and BQ123.
Results: The fAABs/GPCRs from chronic hepatic and PAH SM individuals, but not from acute SM individuals, recognized the three receptors. In the presence of the antagonists, there was a reduction in beating rate changes in cultured cardiomyocytes. In addition, binding sites on the extracellular domain functionality of fAABs were identified, and IgG1 and/or IgG3 antibodies were found to be related to fAABs.
Conclusion: Our data suggest that fAABs against GPCR play an essential role in vascular activity in chronic SM (hepatic and PAH) and might be involved in the development of hypertensive forms of SM.
Competing Interests: Authors JM and GW were employed by Berlin Cures GmbH. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The authors declare that this study received funding from Berlin Cures GmbH. Dr. JM and Dr. GW work in this company. The funder had the following involvement in the study: study design; measurement, identification, and characterization of the functional autoantibodies against G-protein coupled receptors in the sera of patients infected with Schistosoma mansoni.
(Copyright © 2024 Botoni, Lambertucci, Santos, Müller, Talvani and Wallukat.)
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فهرسة مساهمة: Keywords: GPCR; Schistosoma mansoni; angiotensin II; endothelin-1; inflammation; pulmonary hypertension; α1adrenoceptor
المشرفين على المادة: 0 (Autoantibodies)
0 (Receptors, G-Protein-Coupled)
تواريخ الأحداث: Date Created: 20240702 Date Completed: 20240702 Latest Revision: 20240703
رمز التحديث: 20240703
مُعرف محوري في PubMed: PMC11216020
DOI: 10.3389/fimmu.2024.1404384
PMID: 38953035
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-3224
DOI:10.3389/fimmu.2024.1404384