دورية أكاديمية
Serotype distribution, antibiotic resistance, multilocus sequence typing, and virulence factors of invasive and non-invasive Streptococcus pneumoniae in Northeast China from 2000 to 2021.
| العنوان: | Serotype distribution, antibiotic resistance, multilocus sequence typing, and virulence factors of invasive and non-invasive Streptococcus pneumoniae in Northeast China from 2000 to 2021. |
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| المؤلفون: | Xu Y; Department of Laboratory Medicine, Shengjing Hospital of China Medical University, Liaoning Clinical Research Center for Laboratory Medicine, Shenyang, 110004, China., Zhou X; Department of Laboratory Medicine, Shengjing Hospital of China Medical University, Liaoning Clinical Research Center for Laboratory Medicine, Shenyang, 110004, China., Zheng W; Department of Laboratory Medicine, Shengjing Hospital of China Medical University, Liaoning Clinical Research Center for Laboratory Medicine, Shenyang, 110004, China., Cui B; Department of Laboratory Medicine, Shengjing Hospital of China Medical University, Liaoning Clinical Research Center for Laboratory Medicine, Shenyang, 110004, China., Xie C; Department of Laboratory Medicine, Shengjing Hospital of China Medical University, Liaoning Clinical Research Center for Laboratory Medicine, Shenyang, 110004, China., Liu Y; Department of Laboratory Medicine, Shengjing Hospital of China Medical University, Liaoning Clinical Research Center for Laboratory Medicine, Shenyang, 110004, China., Qin X; Department of Laboratory Medicine, Shengjing Hospital of China Medical University, Liaoning Clinical Research Center for Laboratory Medicine, Shenyang, 110004, China. qinxs@sj-hospital.org., Liu J; Department of Laboratory Medicine, Shengjing Hospital of China Medical University, Liaoning Clinical Research Center for Laboratory Medicine, Shenyang, 110004, China. liujh@sj-hospital.org. |
| المصدر: | Medical microbiology and immunology [Med Microbiol Immunol] 2024 Jul 02; Vol. 213 (1), pp. 12. Date of Electronic Publication: 2024 Jul 02. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0314524 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-1831 (Electronic) Linking ISSN: 03008584 NLM ISO Abbreviation: Med Microbiol Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin, New York, Springer-Verlag. |
| مواضيع طبية MeSH: | Streptococcus pneumoniae*/genetics , Streptococcus pneumoniae*/drug effects , Streptococcus pneumoniae*/classification , Streptococcus pneumoniae*/pathogenicity , Streptococcus pneumoniae*/isolation & purification , Multilocus Sequence Typing* , Virulence Factors*/genetics , Pneumococcal Infections*/microbiology , Pneumococcal Infections*/epidemiology , Serogroup* , Anti-Bacterial Agents*/pharmacology, Humans ; China/epidemiology ; Child, Preschool ; Infant ; Middle Aged ; Adolescent ; Adult ; Child ; Aged ; Young Adult ; Aged, 80 and over ; Infant, Newborn ; Microbial Sensitivity Tests ; Female ; Male ; Drug Resistance, Bacterial ; Drug Resistance, Multiple, Bacterial/genetics |
| مستخلص: | Streptococcus pneumoniae infection is a major public health concern with high morbidity and mortality rates. This study aimed to evaluate the serotype distribution, antimicrobial resistance changes, clonal composition, and virulence factors of S. pneumoniae isolates causing pneumococcal disease in northeast China from 2000 to 2021. A total of 1,454 S. pneumoniae isolates were included, with 568 invasive strains and 886 non-invasive strains. The patients from whom the S. pneumoniae were isolated ranged in age from 26 days to 95 years, with those ≤ 5 years old comprising the largest group (67.19%). 19 F, 19 A, 23 F, 14, and 6B were the most common serotypes, of which 19 A and 19 F were the main serotypes of invasive and non-invasive S. pneumoniae, respectively. CC271 was the most common multilocus sequence type. Serotype 14 had the lowest expression of cbpA, rrgA, and psrP genes, but expression levels of 19 A and 19 F genes were similar. All isolates were sensitive to ertapenem, moxifloxacin, linezolid, and vancomycin but highly resistant to macrolides, tetracyclines, and cotrimoxazole. Simultaneous resistance to erythromycin, clindamycin, tetracyclines, and trimethoprim/sulfamethoxazole was common pattern among multidrug-resistant isolates. Non-invasive S. pneumoniae had higher resistance to β-lactam antibiotics than invasive strains. 19 A and 19 F were the main strains of penicillin-resistant S. pneumoniae. The resistance rate of β-lactam antibiotics decreased from 2017 to 2021 compared to previous periods. Including PCV13 in the national immunization program can reduce the morbidity and mortality rates of pneumococcal disease effectively. (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
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| فهرسة مساهمة: | Keywords: Streptococcus pneumoniae; Drug resistance; Multilocus sequence typing; Serological typing; Vaccine coverage |
| المشرفين على المادة: | 0 (Virulence Factors) 0 (Anti-Bacterial Agents) |
| تواريخ الأحداث: | Date Created: 20240702 Date Completed: 20240702 Latest Revision: 20240702 |
| رمز التحديث: | 20240703 |
| DOI: | 10.1007/s00430-024-00797-w |
| PMID: | 38954065 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1432-1831 |
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| DOI: | 10.1007/s00430-024-00797-w |