دورية أكاديمية
Bioinspired Self-Adhesive Multifunctional Lubricated Coating for Biomedical Implant Applications.
| العنوان: | Bioinspired Self-Adhesive Multifunctional Lubricated Coating for Biomedical Implant Applications. |
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| المؤلفون: | Jia Y; Joint Diseases Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing 102218, China.; State Key Laboratory of Tribology in Advanced Equipment, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China., Zhao Y; State Key Laboratory of Tribology in Advanced Equipment, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China., Zhang H; Joint Diseases Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing 102218, China.; State Key Laboratory of Tribology in Advanced Equipment, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China. |
| المصدر: | ACS applied bio materials [ACS Appl Bio Mater] 2024 Jul 15; Vol. 7 (7), pp. 4307-4322. Date of Electronic Publication: 2024 Jul 02. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: ACS Publications Country of Publication: United States NLM ID: 101729147 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2576-6422 (Electronic) Linking ISSN: 25766422 NLM ISO Abbreviation: ACS Appl Bio Mater Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : ACS Publications, [2018]- |
| مواضيع طبية MeSH: | Escherichia coli*/drug effects , Staphylococcus aureus*/drug effects , Coated Materials, Biocompatible*/chemistry , Coated Materials, Biocompatible*/pharmacology , Materials Testing* , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/chemical synthesis , Surface Properties*, Particle Size ; Prostheses and Implants ; Humans ; Microbial Sensitivity Tests ; Animals ; Polymers/chemistry ; Polymers/pharmacology ; Stainless Steel/chemistry ; Lubrication ; Serum Albumin, Bovine/chemistry |
| مستخلص: | In the realm of clinical applications, the concern surrounding biomedical device-related infections (BDI) is paramount. To mitigate the risk associated with BDI, enhancing surface characteristics such as lubrication and antibacterial efficacy is considered as a strategic approach. This study delineated the synthesis of a multifunctional copolymer, embodying self-adhesive, lubricating, and antibacterial properties, achieved through free radical polymerization and a carbodiimide coupling reaction. The copolymer was adeptly modified on the surface of stainless steel 316L (SS316L) substrates by employing a facile dip-coating technique. Comprehensive characterizations were performed by using an array of analytical techniques including Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, optical interferometry, scanning electron microscopy, and atomic force microscopy. Nanoscale tribological assessments revealed a notable reduction in the value of the friction coefficient of the copolymer-coated SS316L substrates compared to bare SS316L samples. The coating demonstrated exceptional resistance to protein adsorption, as evidenced in protein contamination models employing bovine serum albumin and fibrinogen. The bactericidal efficacy of the copolymer-modified surfaces was significantly improved against pathogenic strains such as Staphylococcus aureus and Escherichia coli . Additionally, in vitro evaluations of blood compatibility and cellular compatibility underscored the remarkable anticoagulant performance and biocompatibility. Collectively, these findings indicated that the developed copolymer coating represented a promising candidate, with its facile modification approach, for augmenting lubrication and antifouling properties in the field of biomedical implant applications. |
| فهرسة مساهمة: | Keywords: antibacterial property; bioinspired coating; enhanced lubrication; self-adhesion; surface modification |
| المشرفين على المادة: | 0 (Coated Materials, Biocompatible) 0 (Anti-Bacterial Agents) 0 (Polymers) 12597-68-1 (Stainless Steel) 27432CM55Q (Serum Albumin, Bovine) |
| تواريخ الأحداث: | Date Created: 20240702 Date Completed: 20240715 Latest Revision: 20240715 |
| رمز التحديث: | 20240715 |
| DOI: | 10.1021/acsabm.4c00144 |
| PMID: | 38954747 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 2576-6422 |
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| DOI: | 10.1021/acsabm.4c00144 |