دورية أكاديمية
Geosmin, a Food- and Water-Deteriorating Sesquiterpenoid and Ambivalent Semiochemical, Activates Evolutionary Conserved Receptor OR11A1.
العنوان: | Geosmin, a Food- and Water-Deteriorating Sesquiterpenoid and Ambivalent Semiochemical, Activates Evolutionary Conserved Receptor OR11A1. |
---|---|
المؤلفون: | Ball L; TUM School of Life Sciences, Technical University of Munich, Freising 85354, Germany.; Leibniz Institute for Food Systems Biology at the Technical University of Munich, Freising 85354, Germany., Frey T; TUM School of Life Sciences, Technical University of Munich, Freising 85354, Germany.; Leibniz Institute for Food Systems Biology at the Technical University of Munich, Freising 85354, Germany.; Tecan Deutschland GmbH, Crailsheim 74564, Germany., Haag F; Leibniz Institute for Food Systems Biology at the Technical University of Munich, Freising 85354, Germany., Frank S; Leibniz Institute for Food Systems Biology at the Technical University of Munich, Freising 85354, Germany., Hoffmann S; Leibniz Institute for Food Systems Biology at the Technical University of Munich, Freising 85354, Germany., Laska M; IFM Biology, Linköping University, Linköping 581 83, Sweden., Steinhaus M; Leibniz Institute for Food Systems Biology at the Technical University of Munich, Freising 85354, Germany., Neuhaus K; Core Facility Microbiome, ZIEL - Institute for Food & Health, Technical University of Munich, Freising 85354, Germany., Krautwurst D; Leibniz Institute for Food Systems Biology at the Technical University of Munich, Freising 85354, Germany. |
المصدر: | Journal of agricultural and food chemistry [J Agric Food Chem] 2024 Jul 17; Vol. 72 (28), pp. 15865-15874. Date of Electronic Publication: 2024 Jul 02. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Washington, American Chemical Society. |
مواضيع طبية MeSH: | Naphthols*/metabolism , Naphthols*/chemistry , Naphthols*/analysis , Sesquiterpenes*/metabolism , Sesquiterpenes*/analysis , Sesquiterpenes*/chemistry , Receptors, Odorant*/metabolism , Receptors, Odorant*/genetics , Receptors, Odorant*/chemistry, Animals ; Humans ; Rats ; Pheromones/metabolism ; Pheromones/chemistry ; Pheromones/analysis ; Odorants/analysis |
مستخلص: | Geosmin, a ubiquitous volatile sesquiterpenoid of microbiological origin, is causative for deteriorating the quality of many foods, beverages, and drinking water, by eliciting an undesirable "earthy/musty" off-flavor. Moreover, and across species from worm to human, geosmin is a volatile, chemosensory trigger of both avoidance and attraction behaviors, suggesting its role as semiochemical. Volatiles typically are detected by chemosensory receptors of the nose, which have evolved to best detect ecologically relevant food-related odorants and semiochemicals. An insect receptor for geosmin was recently identified in flies. A human geosmin-selective receptor, however, has been elusive. Here, we report on the identification and characterization of a human odorant receptor for geosmin, with its function being conserved in orthologs across six mammalian species. Notably, the receptor from the desert-dwelling kangaroo rat showed a more than 100-fold higher sensitivity compared to its human ortholog and detected geosmin at low nmol/L concentrations in extracts from geosmin-producing actinomycetes. |
References: | Nat Microbiol. 2020 Jun;5(6):821-829. (PMID: 32251369) Mar Pollut Bull. 2022 May;178:113579. (PMID: 35398689) Nature. 2008 Apr 24;452(7190):1002-6. (PMID: 18408712) Appl Environ Microbiol. 1982 Mar;43(3):708-14. (PMID: 16345978) J Food Sci Technol. 2019 Oct;56(10):4585-4594. (PMID: 31686690) Cell. 2014 May 8;157(4):785-94. (PMID: 24813606) Mol Biol Evol. 2018 Jun 1;35(6):1547-1549. (PMID: 29722887) Anim Cogn. 2022 Feb;25(1):53-61. (PMID: 34292432) Water Sci Technol. 2007;55(5):249-56. (PMID: 17489417) J Microbiol Methods. 2010 Oct;83(1):48-52. (PMID: 20655340) Appl Environ Microbiol. 1992 Sep;58(9):3170-2. (PMID: 1444431) Harmful Algae. 2019 Apr;84:19-26. (PMID: 31128804) J Biol Methods. 2017 Dec 15;4(4):e82. (PMID: 31453236) Water Res. 2006 May;40(9):1741-53. (PMID: 16600325) J Appl Microbiol. 2015 May;118(5):1144-51. (PMID: 25580564) Life (Basel). 2015 Jan 21;5(1):269-93. (PMID: 25615610) Proc Natl Acad Sci U S A. 2020 Feb 11;117(6):2957-2967. (PMID: 31974307) Chembiochem. 2023 Jun 15;24(12):e202300101. (PMID: 36802402) FASEB J. 2021 Jun;35(6):e21638. (PMID: 34047404) Biosens Bioelectron. 2015 Dec 15;74:199-206. (PMID: 26143459) Cell. 2012 Dec 7;151(6):1345-57. (PMID: 23217715) Sci Total Environ. 2019 Nov 1;689:789-796. (PMID: 31280161) J Physiol. 1993 Aug;468:1-10. (PMID: 8254501) Methods Mol Biol. 2013;1003:85-97. (PMID: 23585035) J Chromatogr A. 2016 Jan 8;1428:72-85. (PMID: 26372442) Appl Environ Microbiol. 2007 Jul;73(14):4395-406. (PMID: 17400777) Physiol Rev. 1952 Apr;32(2):135-66. (PMID: 14929697) Nat Chem Biol. 2007 Nov;3(11):711-5. (PMID: 17873868) Water Res. 2018 Nov 15;145:30-38. (PMID: 30118975) Int J Environ Res Public Health. 2022 Jul 29;19(15):. (PMID: 35954649) J Agric Food Chem. 2003 Feb 12;51(4):1026-9. (PMID: 12568567) Plants (Basel). 2022 Mar 14;11(6):. (PMID: 35336651) Sci Rep. 2020 May 26;10(1):8679. (PMID: 32457360) Cell. 1991 Apr 5;65(1):175-87. (PMID: 1840504) Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1541-6. (PMID: 12563033) Curr Opin Biotechnol. 2009 Feb;20(1):14-8. (PMID: 19299118) Front Microbiol. 2021 Nov 01;12:741750. (PMID: 34790181) Chem Senses. 2017 Mar 1;42(3):181-193. (PMID: 27916747) J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2018 Oct;204(9-10):821-833. (PMID: 30203157) Proc Natl Acad Sci U S A. 2019 May 7;116(19):9475-9480. (PMID: 31040214) Environ Microbiol. 2023 Sep;25(9):1565-1574. (PMID: 36999338) Hum Genomics. 2008 Sep;3(1):87-97. (PMID: 19129093) Am J Physiol. 1978 Aug;235(2):E97-102. (PMID: 686171) J Org Chem. 2005 Jun 24;70(13):5174-82. (PMID: 15960521) J Gen Physiol. 2010 Nov;136(5):529-40. (PMID: 20974772) Chem Senses. 2017 Mar 1;42(3):195-210. (PMID: 27916748) Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18682-7. (PMID: 20930117) Curr Biol. 2020 Jan 6;30(1):127-134.e5. (PMID: 31839454) PLoS One. 2014 May 06;9(5):e96333. (PMID: 24800820) J Labelled Comp Radiopharm. 2020 Sep;63(11):476-481. (PMID: 32725638) Nature. 2008 Apr 24;452(7190):1007-11. (PMID: 18408711) Sci Adv. 2019 Jul 31;5(7):eaax0396. (PMID: 31392275) Chemosphere. 2017 Aug;181:9-18. (PMID: 28414956) Nat Neurosci. 2014 Jan;17(1):114-20. (PMID: 24316890) Int J Anal Chem. 2021 May 8;2021:9980212. (PMID: 34046066) Appl Environ Microbiol. 2022 Apr 12;88(7):e0009322. (PMID: 35323022) Hum Genomics. 2009 Dec;4(2):107-18. (PMID: 20038498) Nat Rev Neurosci. 2010 Mar;11(3):188-200. (PMID: 20145624) J Gen Virol. 1977 Jul;36(1):59-74. (PMID: 886304) Clin Chem. 2014 Dec;60(12):1473-9. (PMID: 25274554) Chem Rev. 2006 Sep;106(9):4099-112. (PMID: 16967929) Elife. 2022 Jul 08;11:. (PMID: 35801697) FASEB J. 2021 Feb;35(2):e21274. (PMID: 33464692) Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2584-9. (PMID: 14983052) Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13446-13451. (PMID: 31209046) Antonie Van Leeuwenhoek. 2005 Aug;88(2):131-9. (PMID: 16096689) Zoological Lett. 2018 Feb 15;4:4. (PMID: 29468086) Brain Res Dev Brain Res. 1989 Mar 1;46(1):9-19. (PMID: 2706774) J Anat. 2012 Dec;221(6):609-21. (PMID: 23035637) Angew Chem Int Ed Engl. 2014 Jul 7;53(28):7124-43. (PMID: 24939725) Front Microbiol. 2020 Sep 30;11:557253. (PMID: 33101231) Environ Monit Assess. 2021 Mar 22;193(4):204. (PMID: 33751262) J Agric Food Chem. 2021 Apr 21;69(15):4501-4508. (PMID: 33844919) Percept Psychophys. 1986 Apr;39(4):281-6. (PMID: 3737357) Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1970-5. (PMID: 16446455) Genome Biol Evol. 2020 Dec 6;12(12):2289-2302. (PMID: 33022031) PLoS Genet. 2012;8(7):e1002821. (PMID: 22807691) Oecologia. 2015 Aug;178(4):1045-62. (PMID: 25842296) PLoS Pathog. 2020 Sep 10;16(9):e1008800. (PMID: 32913361) Beilstein J Org Chem. 2019 May 29;15:1181-1193. (PMID: 31293665) Food Chem. 2023 Nov 15;426:136492. (PMID: 37295052) Chem Senses. 1999 Dec;24(6):637-45. (PMID: 10587496) Chem Rev. 2019 Jan 9;119(1):36-93. (PMID: 30372041) J Agric Food Chem. 2015 Nov 4;63(43):9410-20. (PMID: 26451762) Appl Microbiol. 1965 Nov;13(6):935-8. (PMID: 5866039) Nat Commun. 2018 Jul 23;9(1):2887. (PMID: 30038239) Comput Appl Biosci. 1992 Jun;8(3):275-82. (PMID: 1633570) Neurosci Res. 2011 Dec;71(4):355-60. (PMID: 21893110) J Agric Food Chem. 2000 Oct;48(10):4835-8. (PMID: 11052742) Harmful Algae. 2022 Mar;113:102185. (PMID: 35287926) J Agric Food Chem. 2008 Jun 11;56(11):4120-7. (PMID: 18476695) |
فهرسة مساهمة: | Keywords: GPCR; high-throughput screening; olfaction; sensor |
المشرفين على المادة: | MYW912WXJ4 (geosmin) 0 (Naphthols) 0 (Sesquiterpenes) 0 (Receptors, Odorant) 0 (Pheromones) |
تواريخ الأحداث: | Date Created: 20240702 Date Completed: 20240717 Latest Revision: 20240724 |
رمز التحديث: | 20240725 |
مُعرف محوري في PubMed: | PMC11261619 |
DOI: | 10.1021/acs.jafc.4c01515 |
PMID: | 38955350 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1520-5118 |
---|---|
DOI: | 10.1021/acs.jafc.4c01515 |