التفاصيل البيبلوغرافية
| العنوان: |
[Advances in gene therapy for Alport syndrome]. |
| المؤلفون: |
Shen X; Department of Nephrology, Children's Hospital of Nanjing Medical University, Nanjing 210008, China., Zheng BX; Nanjing Key Laboratory of Paediatrics, Children's Hospital of Nanjing Medical University, Nanjing 210008, China., Huang SM; Department of Nephrology, Children's Hospital of Nanjing Medical University, Nanjing 210008, China. |
| المصدر: |
Zhonghua er ke za zhi = Chinese journal of pediatrics [Zhonghua Er Ke Za Zhi] 2024 Jul 02; Vol. 62 (7), pp. 692-695. |
| نوع المنشور: |
Journal Article; Review |
| اللغة: |
Chinese |
| بيانات الدورية: |
Publisher: Chinese Medical Association Country of Publication: China NLM ID: 0417427 Publication Model: Print Cited Medium: Print ISSN: 0578-1310 (Print) Linking ISSN: 05781310 NLM ISO Abbreviation: Zhonghua Er Ke Za Zhi Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Beijing : Chinese Medical Association, 1950 |
| مواضيع طبية MeSH: |
Nephritis, Hereditary*/therapy , Nephritis, Hereditary*/genetics , Genetic Therapy*/methods , Collagen Type IV*/genetics , Disease Models, Animal*, Humans ; Animals ; Mutation ; Genetic Vectors ; Gene Transfer Techniques ; Mice ; Basement Membrane/metabolism |
| فهرسة مساهمة: |
Local Abstract: [Publisher, Chinese] Alport综合征是一种以基底膜结构异常为特征的遗传性肾脏疾病，临床上表现为进行性肾功能丧失、感音神经性听力损失和各种眼部异常，由负责编码基底膜Ⅳ型胶原蛋白α3、α4和α5链的基因变异引起。尚无根治性治疗方法，药物治疗只能延缓病情进展。近年来国内外学者在Alport综合征基因治疗研究方面取得了一定的进展与收获。本文旨在从动物模型、基因转移载体、实验性基因治疗方法3个角度综述Alport综合征基因治疗的研究现状及最新进展，并讨论基因治疗可能面临的问题与挑战。. |
| المشرفين على المادة: |
0 (Collagen Type IV) |
| تواريخ الأحداث: |
Date Created: 20240702 Date Completed: 20240702 Latest Revision: 20240702 |
| رمز التحديث: |
20240703 |
| DOI: |
10.3760/cma.j.cn112140-20240222-00118 |
| PMID: |
38955691 |
| قاعدة البيانات: |
MEDLINE |
