دورية أكاديمية
[Fistula associated anal adenocarcinoma: report of a case].
| العنوان: | [Fistula associated anal adenocarcinoma: report of a case]. |
|---|---|
| المؤلفون: | Wei JJ; Department of Pathology, the Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China., Dong QJ; Department of Anorectal Surgery, the Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China., Zhao QF; Department of Radiology, the Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China., Wang YW; Department of Pathology, the Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China., Liu AF; Department of Pathology, the Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China., Zhang XY; Department of Pathology, the Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China. |
| المصدر: | Zhonghua bing li xue za zhi = Chinese journal of pathology [Zhonghua Bing Li Xue Za Zhi] 2024 Jul 08; Vol. 53 (7), pp. 759-761. |
| نوع المنشور: | Journal Article; Case Reports |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Zhonghua Yixuehui Country of Publication: China NLM ID: 0005331 Publication Model: Print Cited Medium: Print ISSN: 0529-5807 (Print) Linking ISSN: 05295807 NLM ISO Abbreviation: Zhonghua Bing Li Xue Za Zhi Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Beijing : Zhonghua Yixuehui |
| مواضيع طبية MeSH: | Anus Neoplasms*/pathology , Anus Neoplasms*/genetics , Anus Neoplasms*/diagnosis , Adenocarcinoma*/pathology , Adenocarcinoma*/genetics , Adenocarcinoma*/metabolism , Rectal Fistula*/pathology, Humans ; Male ; Adult ; Proto-Oncogene Proteins p21(ras)/genetics ; Mucin-2/metabolism |
| فهرسة مساهمة: | Local Abstract: [Publisher, Chinese] 瘘管相关性肛门腺癌是一种罕见的肛门肿瘤，本文报道1例。该患者为37岁男性，肛瘘伴反复肛旁结块、肿痛溃脓20余年，磁共振成像检查示左侧高位肛周脓肿伴复杂性括约肌间瘘。镜下观察：纤维及炎性肉芽组织中见大量细胞外黏液，黏液被纤维间隔分成大小不一的黏液湖，部分纤维间隔表面衬覆梁索状异型腺上皮，局部乳头状增生，细胞多呈柱状，核圆形或卵圆形位于基底部，散在少量杯状细胞，局部细胞异型明显，极性紊乱，核仁清晰，小灶区域黏液湖内可见簇状或印戒样细胞，局灶区域伴出血及含铁血黄素沉积。免疫组织化学：异型上皮细胞细胞角蛋白（CK）7、CK20、MUC2、CDX2、SATB2、Villin、MSH2、MSH6、PMS2、MLH1阳性，MUC5AC部分阳性，突触素局灶区域阳性，MUC6、GCDFP15、嗜铬粒素A阴性。分子检测：KRAS基因第2号外显子第12位密码子突变，NRAS、BRAF V600E及PIK3CA基因未见突变。本文回顾其临床病理特征并复习相关文献，旨在提高对该病的认识，避免漏诊、误诊。. |
| المشرفين على المادة: | EC 3.6.5.2 (Proto-Oncogene Proteins p21(ras)) 0 (KRAS protein, human) 0 (Mucin-2) |
| تواريخ الأحداث: | Date Created: 20240702 Date Completed: 20240702 Latest Revision: 20240702 |
| رمز التحديث: | 20240703 |
| DOI: | 10.3760/cma.j.cn112151-20231219-00424 |
| PMID: | 38955716 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0529-5807 |
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| DOI: | 10.3760/cma.j.cn112151-20231219-00424 |