دورية أكاديمية
Synchronized Glioma Insights: Trends, Blood Group Correlations, Staging Dynamics, and the Vanguard of Liquid Biopsy Advancements.
| العنوان: | Synchronized Glioma Insights: Trends, Blood Group Correlations, Staging Dynamics, and the Vanguard of Liquid Biopsy Advancements. |
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| المؤلفون: | Sheikh RA; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, 21589, Saudi Arabia., Naqvi S; Department of Biomedical Sciences, College of Medicine, Gulf Medical University, Ajman, United Arab Emirates., Al-Sulami AM; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, 21589, Saudi Arabia., Bayamin M; Medical Oncology Consultant, King Abdullah Medical City Makkah. Saudi Council for Health Specialist Medical Oncology Program. Makka, Saudi Arabia., Samsahan A; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, 21589, Saudi Arabia., Baig MR; Department of Clinical Pharmacy & Pharmacotherapeutics, Dubai Pharmacy College for Girls, Dubai Medical University, Dubai, United Arab Emirates., Al-Abbasi FA; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, 21589, Saudi Arabia., Almalki NAR; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, 21589, Saudi Arabia., Asar TO; Department of Biology, College of Science and Arts at Alkamil, University of Jeddah, Saudi Arabia., Anwar F; Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, 21589, Saudi Arabia. |
| المصدر: | CNS & neurological disorders drug targets [CNS Neurol Disord Drug Targets] 2024 Jul 02. Date of Electronic Publication: 2024 Jul 02. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 101269155 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1996-3181 (Electronic) Linking ISSN: 18715273 NLM ISO Abbreviation: CNS Neurol Disord Drug Targets Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Saif Zone, Sharjah, U.A.E.; San Francisco, CA : Bentham Science Publishers, c2006- |
| مستخلص: | Background: Gliomas are the most frequent, heterogeneous group of tumors arising from glial cells, characterized by difficult monitoring, poor prognosis, and fatality. Tissue biopsy is an established procedure for tumor cell sampling that aids diagnosis, tumor grading, and prediction of prognosis. Materials and Methods: We studied and compared the levels of liquid biopsy markers in patients with different grades of glioma. Also, we tried to prove the potential association between glioma and specific blood group antigens. Results: 78 patients were found, among whom the maximum percentage with glioblastoma had blood group O+ (53.8%). The second highest frequency had blood group A+ (20.4%), followed by B+ (9.0%) and A- (5.1%), and the least with O-. Liquid biopsy biomarkers included Alanine Aminotransferase (ALT), Lactate Dehydrogenase (LDH), lymphocytes, Urea, Alkaline phosphatase (AST), Neutrophils, and C-Reactive Protein (CRP). The levels of all the components increased significantly with the severity of the glioma, with maximum levels seen in glioblastoma (grade IV), followed by grade III and grade II, respectively. Conclusion: Gliomas have significant clinical challenges due to their progression with heterogeneous nature and aggressive behavior. A liquid biopsy is a non-invasive approach that aids in setting up the status of the patient and figuring out the tumor grade; therefore, it may show diagnostic and prognostic utility. Additionally, our study provides evidence to prove the role of ABO blood group antigens in the development of glioma. However, future clinical research on liquid biopsy will improve the sensitivity and specificity of these tests and confirm their clinical usefulness to guide treatment approaches. . (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.) |
| فهرسة مساهمة: | Keywords: CRP; LFT.; Liquid biopsy; glioma; stages |
| تواريخ الأحداث: | Date Created: 20240703 Latest Revision: 20240703 |
| رمز التحديث: | 20240703 |
| DOI: | 10.2174/0118715273306577240612053957 |
| PMID: | 38956913 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1996-3181 |
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| DOI: | 10.2174/0118715273306577240612053957 |