دورية أكاديمية
أعرض في EDS

Plasma concentration of fucosyltransferase 7 is not associated with the number of clinically overt vaso-occlusive events in sickle cell disease.

التفاصيل البيبلوغرافية
العنوان: Plasma concentration of fucosyltransferase 7 is not associated with the number of clinically overt vaso-occlusive events in sickle cell disease.
المؤلفون: Okpala IE; Department of Haematology and Immunology, University of Nigeria Teaching Hospital, Enugu, Nigeria., Eze OE; Department of Haematology, Enugu State University Teaching Hospital, Enugu, Nigeria., Ezekekwu CA; Department of Haematology and Immunology, University of Nigeria Teaching Hospital, Enugu, Nigeria., Nnakenyi ID; Department of Chemical Pathology, University of Nigeria Teaching Hospital, Enugu, Nigeria., Ilechukwu GU; Department of Haematology and Immunology, University of Nigeria Teaching Hospital, Enugu, Nigeria., Akpa CO; Department of Haematology and Blood Transfusion, Alex Ekwueme Federal University Teaching Hospital, Abakaliki, Nigeria., Nwani EI; Department of Haematology and Blood Transfusion, Alex Ekwueme Federal University Teaching Hospital, Abakaliki, Nigeria., Maduka CJ; Department of Haematology, Federal Medical Centre, Umuahia, Nigeria., Anigbogu IO; Department of Haematology and Immunology, University of Nigeria Teaching Hospital, Enugu, Nigeria., Muoghalu ED; Department of Haematology and Immunology, University of Nigeria Teaching Hospital, Enugu, Nigeria., Ugwu NI; Department of Haematology and Blood Transfusion, Alex Ekwueme Federal University Teaching Hospital, Abakaliki, Nigeria., Ajuba IC; Haematology Department, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria., Aneke JC; Haematology Department, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria., Okoye HC; Department of Haematology and Immunology, University of Nigeria Teaching Hospital, Enugu, Nigeria., Nonyelu CC; Department of Haematology and Immunology, University of Nigeria Teaching Hospital, Enugu, Nigeria., Duru AN; Department of Haematology and Immunology, University of Nigeria Teaching Hospital, Enugu, Nigeria.
المصدر: Ghana medical journal [Ghana Med J] 2023 Sep; Vol. 57 (3), pp. 198-203.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Ghana Medical Association Country of Publication: Ghana NLM ID: 0073210 Publication Model: Print Cited Medium: Internet ISSN: 2616-163X (Electronic) Linking ISSN: 00169560 NLM ISO Abbreviation: Ghana Med J Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Accra : Ghana Medical Association
مواضيع طبية MeSH: Fucosyltransferases*/blood , Anemia, Sickle Cell*/blood , Anemia, Sickle Cell*/complications, Humans ; Adult ; Female ; Male ; Prospective Studies ; Adolescent ; Young Adult ; Middle Aged ; Vascular Diseases/blood ; Vascular Diseases/etiology ; Enzyme-Linked Immunosorbent Assay ; Biomarkers/blood
مستخلص: Objective: To determine if the number of vaso-occlusive events in SCD relates to plasma concentration of fucosyltransferase 7 (FUT7), which catalyses the synthesis of selectin ligands.
Design: A prospective, analytical study.
Setting: Haematology and Chemical Pathology Departments of tertiary healthcare centres.
Participants: Steady state HbSS individuals aged 13-45 years, 20 had 3 or more vaso-occlusive crises that required hospital admission in the previous year (with or without complications of SCD); 17 other HbSS persons had 0-1 vaso-occlusive crisis that required hospital admission in the previous year and no disease complications.
Intervention: Steady-state plasma concentrations of FUT7 measured by ELISA were compared between SCD patients who had one vaso-occlusive crisis requiring hospital treatment in the previous year but no disease complications and those who had >3 crises with or without complications.
Main Outcome Measures: Plasma level of FUT7and the number of vaso-occlusive events in each HbSS patient.
Results: Mean + standard deviation plasma concentration of FUT7 was 8.6 + 2.7 ng/ml in patients with >3 vasoocclusive crises in the previous year and 7.3 + 1.7 ng/ml in those with 0-1 crisis and no complications; independent sample t-test, p > 0.05, not significantly different.
Conclusion: Plasma concentration of fucosyltransferase7 is not associated with the number of vaso-occlusive events in sickle cell disease.
Funding: None declared.
Competing Interests: Conflict of interest: None declared
(Copyright © The Author(s).)
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فهرسة مساهمة: Keywords: Fucosyltransferase7; adhesion molecules; sickle cell disease
المشرفين على المادة: EC 2.4.1.- (Fucosyltransferases)
EC 2.4.1.- (FUT7 protein, human)
0 (Biomarkers)
تواريخ الأحداث: Date Created: 20240703 Date Completed: 20240703 Latest Revision: 20240704
رمز التحديث: 20240704
مُعرف محوري في PubMed: PMC11216735
DOI: 10.4314/gmj.v57i3.6
PMID: 38957672
قاعدة البيانات: MEDLINE
الوصف
تدمد:2616-163X
DOI:10.4314/gmj.v57i3.6