دورية أكاديمية
Iron(III) Binding Properties of PF1140, a Fungal N -Hydroxypyridone, and Activity against Mycoplasma genitalium .
| العنوان: | Iron(III) Binding Properties of PF1140, a Fungal N -Hydroxypyridone, and Activity against Mycoplasma genitalium . |
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| المؤلفون: | Peramuna T; Natural Products Discovery Group, Institute for Natural Products Applications and Research Technologies, Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, Oklahoma 73019, United States., Kim CM; Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington 98104, United States., Aguila LKT; Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington 98104, United States., Wendt KL; Natural Products Discovery Group, Institute for Natural Products Applications and Research Technologies, Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, Oklahoma 73019, United States., Wood GE; Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington 98104, United States., Cichewicz RH; Natural Products Discovery Group, Institute for Natural Products Applications and Research Technologies, Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, Norman, Oklahoma 73019, United States. |
| المصدر: | Journal of natural products [J Nat Prod] 2024 Jul 26; Vol. 87 (7), pp. 1746-1753. Date of Electronic Publication: 2024 Jul 03. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society of Pharmacognosy Country of Publication: United States NLM ID: 7906882 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6025 (Electronic) Linking ISSN: 01633864 NLM ISO Abbreviation: J Nat Prod Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cincinnati, American Society of Pharmacognosy. |
| مواضيع طبية MeSH: | Mycoplasma genitalium*/metabolism , Mycoplasma genitalium*/drug effects , Iron*/metabolism, Molecular Structure ; Microbial Sensitivity Tests ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Pyridones/pharmacology ; Pyridones/chemistry ; Fungi/chemistry ; Fungi/metabolism ; Ferric Compounds/chemistry ; Hydrogen Peroxide ; Siderophores/pharmacology ; Siderophores/chemistry |
| مستخلص: | Mycoplasma genitalium is a sexually transmitted bacterium associated with urogenital disease syndromes in the US and worldwide. The global rise in drug resistance in M. genitalium necessitates the development of novel drugs to treat this pathogen. To address this need, we have screened extracts from a library of fungal isolates assembled through the University of Oklahoma Citizen Science Soil Collection Program. Analysis of one of the bioactive extracts using bioassay-guided fractionation led to the purification of the compound PF1140 ( 1 ) along with a new and several other known pyridones. The N -hydroxy pyridones are generally regarded as siderophores with high binding affinity for iron(III) under physiological conditions. Results from UV-vis absorption spectroscopy-based titration experiments revealed that 1 complexes with Fe 3+ . As M. genitalium does not utilize iron, we propose that the PF1140-iron complex induces cytotoxicity by facilitating the cellular uptake of iron, which reacts with endogenous hydrogen peroxide to produce toxic hydroxyl radicals. |
| المشرفين على المادة: | E1UOL152H7 (Iron) 0 (Anti-Bacterial Agents) 0 (Pyridones) 0 (Ferric Compounds) BBX060AN9V (Hydrogen Peroxide) 0 (Siderophores) |
| تواريخ الأحداث: | Date Created: 20240703 Date Completed: 20240726 Latest Revision: 20240801 |
| رمز التحديث: | 20240801 |
| DOI: | 10.1021/acs.jnatprod.4c00209 |
| PMID: | 38958274 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1520-6025 |
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| DOI: | 10.1021/acs.jnatprod.4c00209 |