دورية أكاديمية
أعرض في EDS

Biocellulose-based hydrogel dressing as a strategy for the management of chronic arterial wounds.

التفاصيل البيبلوغرافية
العنوان: Biocellulose-based hydrogel dressing as a strategy for the management of chronic arterial wounds.
المؤلفون: Moraes CMB; Universidade Estadual Paulista - Hospital Clinics of the Faculty of Medicine of Botucatu - Department of Surgery and Orthopedics - Botucatu (SP), Brazil., Bassanelli AM; Universidade Estadual Paulista - Hospital Clinics of the Faculty of Medicine of Botucatu - Department of Surgery and Orthopedics - Botucatu (SP), Brazil., Rodrigues LDS; Universidade Estadual Paulista - Hospital Clinics of the Faculty of Medicine of Botucatu - Department of Surgery and Orthopedics - Botucatu (SP), Brazil., Barud HDS; Centro Universitário de Araraquara - Biopolymers and Biomaterials Laboratory - Araraquara (SP), Brazil., Fontes ML; Centro Universitário de Araraquara - Biopolymers and Biomaterials Laboratory - Araraquara (SP), Brazil., Lourenção PLTA; Universidade Estadual Paulista - Hospital Clinics of the Faculty of Medicine of Botucatu - Department of Surgery and Orthopedics - Botucatu (SP), Brazil., Castro MCNE; Universidade Estadual Paulista - Hospital Clinics of the Faculty of Medicine of Botucatu - Department of Surgery and Orthopedics - Botucatu (SP), Brazil., Bertanha M; Universidade Estadual Paulista - Hospital Clinics of the Faculty of Medicine of Botucatu - Department of Surgery and Orthopedics - Botucatu (SP), Brazil.
المصدر: Acta cirurgica brasileira [Acta Cir Bras] 2024 Jul 01; Vol. 39, pp. e392924. Date of Electronic Publication: 2024 Jul 01 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Sociedade Brasileira Para O Desenvolvimento Da Pesquisa Em Cirurgia Curso De Pos-Graduacao Em Tecnica Operatoria E Cirurgia Experimental Escola Paulista De Medicina Country of Publication: Brazil NLM ID: 9103983 Publication Model: eCollection Cited Medium: Internet ISSN: 1678-2674 (Electronic) Linking ISSN: 01028650 NLM ISO Abbreviation: Acta Cir Bras Subsets: MEDLINE
أسماء مطبوعة: Publication: Sao Paulo : Sociedade Brasileira Para O Desenvolvimento Da Pesquisa Em Cirurgia Curso De Pos-Graduacao Em Tecnica Operatoria E Cirurgia Experimental Escola Paulista De Medicina
Original Publication: São Paulo : A Sociedade,
مواضيع طبية MeSH: Wound Healing* , Quality of Life*, Humans ; Male ; Female ; Prospective Studies ; Middle Aged ; Aged ; Treatment Outcome ; Chronic Disease ; Cellulose/therapeutic use ; Cellulose/administration & dosage ; Leg Ulcer/therapy ; Bandages ; Aged, 80 and over ; Pain Measurement ; Hydrogels/therapeutic use
مستخلص: Purpose: To evaluate using a biocellulose-based hydrogel as an adjuvant in the healing process of arterial ulcers.
Methods: A prospective single group quasi-experimental study was carried out with chronic lower limb arterial ulcer patients. These patients received biocellulose-based hydrogel dressings and outpatient guidance on dressing and periodic reassessments. The primary outcomes were the ulcer-healing rate and product safety, which were assessed by ulcer area measured in photographic records of pre-treatment and posttreatment after 7, 30, and 60 days. Secondary outcomes were related to clinical assessment by the quality-of-life scores (SF-36 and EQ-5D) and pain, evaluated by the visual analogue scale (VAS).
Results: Seventeen participants were included, and one of them was excluded. Six patients (37%) had complete wound healing, and all patients had a significant reduction in the ulcer area during follow-up (233.6mm2 versus 2.7mm2) and reduction on the score PUSH 3.0 (p < 0.0001). The analysis of the SF-36 and EQ-5D questionnaires showed a statistically significant improvement in almost all parameters analyzed and with a reduction of pain assessed by the VAS.
Conclusions: The biocellulose-based hydrogel was safe and showed a good perspective to promoting the necessary conditions to facilitate partial or complete healing of chronic arterial ulcers within a 60-day follow-up. Quality of life and pain were positively affected by the treatment.
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المشرفين على المادة: 9004-34-6 (Cellulose)
0 (Hydrogels)
تواريخ الأحداث: Date Created: 20240703 Date Completed: 20240703 Latest Revision: 20240705
رمز التحديث: 20240705
مُعرف محوري في PubMed: PMC11216531
DOI: 10.1590/acb392924
PMID: 38958305
قاعدة البيانات: MEDLINE
الوصف
تدمد:1678-2674
DOI:10.1590/acb392924