دورية أكاديمية
The mechanics of correlated variability in segregated cortical excitatory subnetworks.
| العنوان: | The mechanics of correlated variability in segregated cortical excitatory subnetworks. |
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| المؤلفون: | Negrón A; Department of Applied Mathematics, Illinois Institute of Technology, Chicago, IL 60616.; Grossman Center for Quantitative Biology and Human Behavior, University of Chicago, Chicago, IL 60637., Getz MP; Grossman Center for Quantitative Biology and Human Behavior, University of Chicago, Chicago, IL 60637.; Department of Neurobiology, University of Chicago, Chicago, IL 60637.; Department of Statistics, University of Chicago, Chicago, IL 60637., Handy G; Grossman Center for Quantitative Biology and Human Behavior, University of Chicago, Chicago, IL 60637.; Department of Neurobiology, University of Chicago, Chicago, IL 60637.; Department of Statistics, University of Chicago, Chicago, IL 60637., Doiron B; Grossman Center for Quantitative Biology and Human Behavior, University of Chicago, Chicago, IL 60637.; Department of Neurobiology, University of Chicago, Chicago, IL 60637.; Department of Statistics, University of Chicago, Chicago, IL 60637. |
| المصدر: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Jul 09; Vol. 121 (28), pp. e2306800121. Date of Electronic Publication: 2024 Jul 03. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : National Academy of Sciences |
| مواضيع طبية MeSH: | Pyramidal Cells*/physiology , Models, Neurological* , Nerve Net*/physiology, Animals ; Mice ; Visual Cortex/physiology ; Primary Visual Cortex/physiology |
| مستخلص: | Understanding the genesis of shared trial-to-trial variability in neuronal population activity within the sensory cortex is critical to uncovering the biological basis of information processing in the brain. Shared variability is often a reflection of the structure of cortical connectivity since it likely arises, in part, from local circuit inputs. A series of experiments from segregated networks of (excitatory) pyramidal neurons in the mouse primary visual cortex challenge this view. Specifically, the across-network correlations were found to be larger than predicted given the known weak cross-network connectivity. We aim to uncover the circuit mechanisms responsible for these enhanced correlations through biologically motivated cortical circuit models. Our central finding is that coupling each excitatory subpopulation with a specific inhibitory subpopulation provides the most robust network-intrinsic solution in shaping these enhanced correlations. This result argues for the existence of excitatory-inhibitory functional assemblies in early sensory areas which mirror not just response properties but also connectivity between pyramidal cells. Furthermore, our findings provide theoretical support for recent experimental observations showing that cortical inhibition forms structural and functional subnetworks with excitatory cells, in contrast to the classical view that inhibition is a nonspecific blanket suppression of local excitation. Competing Interests: Competing interests statement:The authors declare no competing interest. |
| التعليقات: | Update of: bioRxiv. 2023 Apr 27:2023.04.25.538323. doi: 10.1101/2023.04.25.538323. (PMID: 37162867) |
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| معلومات مُعتمدة: | R01 EB026953 United States EB NIBIB NIH HHS; N00014-18-1-2002 DOD | USN | ONR | Office of Naval Research Global (ONRG); GH Burroughs Wellcome Fund (BWF); SCGB Simons Foundation (SF); U19 NS107613 United States NS NINDS NIH HHS; SURF Program Simons Foundation (SF); 1U19NS107613-01 HHS | NIH | National Institute of Mental Health (NIMH); R01EB026953 HHS | NIH | National Institute of Mental Health (NIMH) |
| فهرسة مساهمة: | Keywords: cortical connectivity; excitatory–inhibitory assemblies; inhibition-stabilized network; trial-to-trial variability |
| تواريخ الأحداث: | Date Created: 20240703 Date Completed: 20240703 Latest Revision: 20240719 |
| رمز التحديث: | 20240719 |
| مُعرف محوري في PubMed: | PMC11252788 |
| DOI: | 10.1073/pnas.2306800121 |
| PMID: | 38959037 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1091-6490 |
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| DOI: | 10.1073/pnas.2306800121 |