دورية أكاديمية
أعرض في EDS

Clinicopathologic features and outcomes of bilateral lacrimal gland lesions.

التفاصيل البيبلوغرافية
العنوان: Clinicopathologic features and outcomes of bilateral lacrimal gland lesions.
المؤلفون: He L; Department of Ophthalmology, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.; Department of Ophthalmology, The Third Hospital of Mianyang, Mianyang, Sichuan Province, China., He W; Department of Ophthalmology, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.
المصدر: PloS one [PLoS One] 2024 Jul 03; Vol. 19 (7), pp. e0305717. Date of Electronic Publication: 2024 Jul 03 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Lacrimal Apparatus*/pathology , Lacrimal Apparatus Diseases*/pathology, Humans ; Female ; Male ; Middle Aged ; Adult ; Aged ; Adolescent ; Child ; Young Adult ; Retrospective Studies ; Biopsy ; Lymphoma, B-Cell, Marginal Zone/pathology ; Lymphoma, B-Cell, Marginal Zone/therapy ; China/epidemiology ; Treatment Outcome ; Immunoglobulin G4-Related Disease/pathology ; Immunoglobulin G4-Related Disease/complications
مستخلص: Background: The present study reviewed the clinicopathological features and outcomes of bilateral lacrimal gland lesions.
Methods: The data of 113 patients who underwent lacrimal gland biopsy at the West China Hospital of Sichuan University, China, between January 1, 2010, and December 31, 2021, are presented in this case series. The patients all presented with bilateral lacrimal gland lesions. The collected data included patient demographics, clinical features, the results of laboratory examinations, imaging presentations, histopathological diagnoses, treatments, and outcomes.
Results: The mean age of the 113 enrolled patients was 47.4 ± 14.9 years (range, 11-77 years) with a predominance of females (54.9%, n = 62). The lacrimal gland was the source of the majority of biopsy tissue (98.2%, n = 111). The most prevalent etiology was immunoglobulin G4-related ophthalmic disease (IgG4-ROD) (32.7%, n = 37), followed by idiopathic orbital inflammation (IOI) (28.3%, n = 32), mucosa-associated lymphoid tissue (MALT) lymphoma (17.7%, n = 20), reactive lymphoid hyperplasia (RLH) (10.6%, n = 12), and mantle cell lymphoma (4.4%, n = 5). Patients with IOI were significantly younger than those with IgG4-ROD and MALT lymphoma (t = 2.932, P = 0.005; t = 3.865, P<0.001, respectively). Systemic symptoms were more prevalent among patients with IgG4-ROD (χ2 = 7.916, P = 0.005). The majority of patients were treated with surgery (53.1%, n = 60), with surgery combined with corticosteroid therapy (21.2%, n = 24) being the second most common treatment. The majority of patients (91.2%, n = 103) attained complete resolution, stable disease, or significant improvement.
Conclusion: In conclusion, there are several aetiologies associated with bilateral lacrimal gland lesions, the most prevalent being IgG4-ROD, IOI, and MALT lymphoma. Systemic symptoms were more common in patients with IgG4-ROD. The majority of patients who presented with bilateral lesions of the lacrimal glands responded satisfactorily to treatment, with favorable results.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 He, He. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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تواريخ الأحداث: Date Created: 20240703 Date Completed: 20240703 Latest Revision: 20240705
رمز التحديث: 20240705
مُعرف محوري في PubMed: PMC11221706
DOI: 10.1371/journal.pone.0305717
PMID: 38959275
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0305717