دورية أكاديمية
Harnessing Immunomodulatory Polymers for Treatment of Autoimmunity, Allergy, and Transplant Rejection.
| العنوان: | Harnessing Immunomodulatory Polymers for Treatment of Autoimmunity, Allergy, and Transplant Rejection. |
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| المؤلفون: | Tu AB; Department of Biomedical Engineering, University of California, Davis, California, USA., Krishna G; J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida, USA; email: jlewis@bme.ufl.edu., Smith KR; J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida, USA; email: jlewis@bme.ufl.edu., Lewis JS; Department of Biomedical Engineering, University of California, Davis, California, USA.; J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida, USA; email: jlewis@bme.ufl.edu. |
| المصدر: | Annual review of biomedical engineering [Annu Rev Biomed Eng] 2024 Jul; Vol. 26 (1), pp. 415-440. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Annual Reviews Country of Publication: United States NLM ID: 100883581 Publication Model: Print Cited Medium: Internet ISSN: 1545-4274 (Electronic) Linking ISSN: 15239829 NLM ISO Abbreviation: Annu Rev Biomed Eng Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Palo Alto, Calif. : Annual Reviews, c1999- |
| مواضيع طبية MeSH: | Graft Rejection*/immunology , Graft Rejection*/prevention & control , Polymers*/chemistry , Autoimmunity*/drug effects , Hypersensitivity*/immunology , Hypersensitivity*/therapy, Humans ; Animals ; Biocompatible Materials/chemistry ; Nanoparticles/chemistry ; Autoimmune Diseases/therapy ; Autoimmune Diseases/immunology ; Immunomodulating Agents/therapeutic use ; Immunologic Factors/therapeutic use |
| مستخلص: | Autoimmunity, allergy, and transplant rejection are a collection of chronic diseases that are currently incurable, drastically decrease patient quality of life, and consume considerable health care resources. Underlying each of these diseases is a dysregulated immune system that results in the mounting of an inflammatory response against self or an innocuous antigen. As a consequence, afflicted patients are required to adhere to lifelong regimens of multiple immunomodulatory drugs to control disease and reclaim agency. Unfortunately, current immunomodulatory drugs are associated with a myriad of side effects and adverse events, such as increased risk of cancer and increased risk of serious infection, which negatively impacts patient adherence rates and quality of life. The field of immunoengineering is a new discipline that aims to harness endogenous biological pathways to thwart disease and minimize side effects using novel biomaterial-based strategies. We highlight and discuss polymeric micro/nanoparticles with inherent immunomodulatory properties that are currently under investigation in biomaterial-based therapies for treatment of autoimmunity, allergy, and transplant rejection. |
| فهرسة مساهمة: | Keywords: allergy; autoimmunity; biomaterials; immunomodulation; microparticle; polymers; transplant rejection |
| المشرفين على المادة: | 0 (Polymers) 0 (Biocompatible Materials) 0 (Immunomodulating Agents) 0 (Immunologic Factors) |
| تواريخ الأحداث: | Date Created: 20240703 Date Completed: 20240703 Latest Revision: 20240703 |
| رمز التحديث: | 20240704 |
| DOI: | 10.1146/annurev-bioeng-110122-014306 |
| PMID: | 38959388 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1545-4274 |
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| DOI: | 10.1146/annurev-bioeng-110122-014306 |