دورية أكاديمية
Controlled Study of Metabolic Syndrome Among Offspring of Parents With Bipolar Disorder.
| العنوان: | Controlled Study of Metabolic Syndrome Among Offspring of Parents With Bipolar Disorder. |
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| المؤلفون: | Kulkarni NP; Centre for Youth Bipolar Disorder, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada., Dimick MK; Centre for Youth Bipolar Disorder, Centre for Addiction and Mental Health, Toronto, Ontario, Canada., Kennedy KG; Centre for Youth Bipolar Disorder, Centre for Addiction and Mental Health, Toronto, Ontario, Canada., Axelson DA; Nationwide Children's Hospital and Ohio State College of Medicine, Columbus, Ohio., Sakolsky DJ; Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Diler RS; Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Hafeman DM; Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Goldstein TR; Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Monk KJ; Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Liao F; Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Merranko JA; Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Birmaher B; Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Goldstein BI; Centre for Youth Bipolar Disorder, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada.; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. |
| المصدر: | The Journal of clinical psychiatry [J Clin Psychiatry] 2024 Jul 01; Vol. 85 (3). Date of Electronic Publication: 2024 Jul 01. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Physicians Postgraduate Press Country of Publication: United States NLM ID: 7801243 Publication Model: Electronic Cited Medium: Internet ISSN: 1555-2101 (Electronic) Linking ISSN: 01606689 NLM ISO Abbreviation: J Clin Psychiatry Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Memphis, Tenn., Physicians Postgraduate Press. |
| مواضيع طبية MeSH: | Bipolar Disorder*/epidemiology , Bipolar Disorder*/genetics , Metabolic Syndrome*/epidemiology , Metabolic Syndrome*/genetics , Child of Impaired Parents*/statistics & numerical data, Humans ; Male ; Female ; Adult ; Young Adult ; Adolescent ; Prevalence ; Parents ; Risk Factors ; Case-Control Studies ; Child |
| مستخلص: | Objectives: Bipolar disorder (BD) is highly heritable and associated with increased rates of metabolic syndrome (MetS). However, little is known about MetS in offspring of parents with BD. We therefore examined this topic in the Pittsburgh Bipolar Offspring Study cohort. Methods: Participants included 199 parents (n = 116 BD, diagnosed using DSM-IV ; n = 83 non-BD) and 330 offspring (mean age 19.9 ± 5.3 years), including 198 high-risk offspring of parents with BD (n = 80 affected with a mood disorder) and 132 control offspring. We defined MetS and its components using International Diabetes Federation (IDF) guidelines (primary) and National Cholesterol Education Program (NCEP) guidelines (secondary). Multivariable analyses controlled for age and socioeconomic status in offspring. Sensitivity analyses controlled for psychotropic medications. Results: There was higher prevalence of MetS in parents with BD as compared to controls. NCEP-defined MetS was significantly more prevalent among affected high-risk offspring (16.3%) and controls (15.2%) vs unaffected high-risk offspring (6.0%; χ 2 = 6.54, P = .04). There was greater mean number of MetS components (IDF: 1.7 ± 1.1; NCEP: 1.4 ± 1.0) among affected high-risk offspring vs unaffected high-risk offspring (IDF: 1.2 ± 1.0; NCEP: 1.0 ± 1.0) and controls (IDF: 1.3 ± 1.2; NCEP: 1.1 ± 1.1; IDF: H [2] = 10.26, P = .006; NCEP: H [2] = 9.18, P = .01). Most findings became nonsignificant in multivariable analyses. Some between-group results became nonsignificant after controlling for second-generation antipsychotics. Conclusions: This preliminary study found increased risk of MetS among affected high-risk offspring, which may be attributable to socioeconomic status. Prospective studies may determine timing of MetS onset in relation to mood disorder onset, and the role of socioeconomic status in moderating this association. (© Copyright 2024 Physicians Postgraduate Press, Inc.) |
| تواريخ الأحداث: | Date Created: 20240703 Date Completed: 20240703 Latest Revision: 20240703 |
| رمز التحديث: | 20240704 |
| DOI: | 10.4088/JCP.23m15058 |
| PMID: | 38959498 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1555-2101 |
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| DOI: | 10.4088/JCP.23m15058 |