دورية أكاديمية
Nanophotonic waveguide-based sensing of circulating cell-free mitochondrial DNA: implications for personalized medicine.
| العنوان: | Nanophotonic waveguide-based sensing of circulating cell-free mitochondrial DNA: implications for personalized medicine. |
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| المؤلفون: | Kaur P; Division of Environmental Biotechnology, Genetics & Molecular Biology, ICMR-National Institute for Research in Environmental Health (NIREH), Bhopal, India., Nazeer N; Division of Environmental Biotechnology, Genetics & Molecular Biology, ICMR-National Institute for Research in Environmental Health (NIREH), Bhopal, India., Gurjar V; Division of Environmental Biotechnology, Genetics & Molecular Biology, ICMR-National Institute for Research in Environmental Health (NIREH), Bhopal, India., Tiwari R; Division of Environmental Biotechnology, Genetics & Molecular Biology, ICMR-National Institute for Research in Environmental Health (NIREH), Bhopal, India., Mishra PK; Division of Environmental Biotechnology, Genetics & Molecular Biology, ICMR-National Institute for Research in Environmental Health (NIREH), Bhopal, India. Electronic address: pkm_8bh@yahoo.co.uk. |
| المصدر: | Drug discovery today [Drug Discov Today] 2024 Aug; Vol. 29 (8), pp. 104086. Date of Electronic Publication: 2024 Jul 02. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Ltd. Country of Publication: England NLM ID: 9604391 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5832 (Electronic) Linking ISSN: 13596446 NLM ISO Abbreviation: Drug Discov Today Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Kidlington, Oxford : Irvington, NJ : Elsevier Science Ltd. ; Distributed by Virgin Mailing and Distribution, c1996- |
| مواضيع طبية MeSH: | DNA, Mitochondrial*/genetics , Precision Medicine*/methods , Cell-Free Nucleic Acids*/genetics , Cell-Free Nucleic Acids*/blood, Humans ; Nanotechnology/methods ; Mutation ; Animals ; Mitochondrial Diseases/genetics ; Mitochondrial Diseases/diagnosis |
| مستخلص: | Circulating cell-free mitochondrial DNA (ccf-mtDNA) has emerged as a promising biomarker, with potential implications for disease diagnosis. Changes in mtDNA, such as deletions, mutations or variations in the number of copies, have been associated with mitochondrial disorders, heart diseases, cancer and age-related non-communicable diseases. Previous methods, such as polymerase chain reaction-based approaches, next-generation sequencing and imaging-based techniques, have shown improved accuracy in identifying rare mtDNA variants or mutations, but they have limitations. This article explains the basic principles and benefits of using planar optical waveguide-based detection devices, which represent an advanced approach in the field of sensing. (Copyright © 2024 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: circulating cell-free mitochondrial DNA; nanobiosensor; nanophotonics; planar optical waveguides; translational research |
| المشرفين على المادة: | 0 (DNA, Mitochondrial) 0 (Cell-Free Nucleic Acids) |
| تواريخ الأحداث: | Date Created: 20240703 Date Completed: 20240803 Latest Revision: 20240803 |
| رمز التحديث: | 20240804 |
| DOI: | 10.1016/j.drudis.2024.104086 |
| PMID: | 38960132 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1878-5832 |
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| DOI: | 10.1016/j.drudis.2024.104086 |