دورية أكاديمية
أعرض في EDS

Abnormal platelet parameters in inflammatory bowel disease: a systematic review and meta-analysis.

التفاصيل البيبلوغرافية
العنوان: Abnormal platelet parameters in inflammatory bowel disease: a systematic review and meta-analysis.
المؤلفون: Xu C; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.; Nanjing University of Chinese Medicine, Nanjing, China., Song Z; Nanjing University of Chinese Medicine, Nanjing, China.; Yancheng Binhai Hospital of Traditional Chinese Medicine, Yancheng, China., Hu LT; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.; Nanjing University of Chinese Medicine, Nanjing, China., Tong YH; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.; Nanjing University of Chinese Medicine, Nanjing, China., Hu JY; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China., Shen H; Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China. shenhong999@njucm.edu.cn.
المصدر: BMC gastroenterology [BMC Gastroenterol] 2024 Jul 03; Vol. 24 (1), pp. 214. Date of Electronic Publication: 2024 Jul 03.
نوع المنشور: Journal Article; Systematic Review; Meta-Analysis
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100968547 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-230X (Electronic) Linking ISSN: 1471230X NLM ISO Abbreviation: BMC Gastroenterol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: Mean Platelet Volume* , Inflammatory Bowel Diseases*/blood , Blood Platelets*, Humans ; Platelet Count ; Blood Platelet Disorders/blood ; Blood Platelet Disorders/diagnosis
مستخلص: Background: Platelet dysfunction plays a critical role in the pathogenesis of inflammatory bowel disease (IBD). Despite clinical observations indicating abnormalities in platelet parameters among IBD patients, inconsistencies persist, and these parameters lack standardization for diagnosis or clinical assessment.
Methods: A comprehensive search was conducted in the PubMed, Embase, Web of Science, and Cochrane Library databases for relevant articles published up to December 16th, 2023. A random-effects model was employed to pool the weighted mean difference (WMD) and 95% confidence interval (95% CI) of platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT) between IBD patients and healthy controls, and subgroup analyses were performed.
Results: The meta-analysis included 79 articles with 8,350 IBD patients and 13,181 healthy individuals. The results revealed significantly increased PLT and PCT levels (WMD: 69.910, 95% CI: 62.177, 77.643 10 9 /L; WMD: 0.046%, 95% CI: 0.031%, 0.061%), and decreased MPV levels (WMD: -0.912, 95% CI: -1.086, -0.739 fL) in IBD patients compared to healthy individuals. No significant difference was found in PDW between the IBD and control groups (WMD: -0.207%, 95% CI: -0.655%, 0.241%). Subgroup analysis by disease type and disease activity showed no change in the differences for PLT, PCT, and MPV in the ulcerative colitis and Crohn's disease groups, as well as the active and inactive groups. Notably, the active group exhibited significantly lower PDW levels than the control group (WMD: -1.138%, 95% CI: -1.535%, -0.741%).
Conclusions: Compared with healthy individuals, IBD patients display significantly higher PLT and PCT and significantly lower MPV. Monitoring the clinical manifestations of platelet abnormalities serves as a valuable means to obtain diagnostic and prognostic information. Conversely, proactive measures should be taken to prevent the consequences of platelet abnormalities in individuals with IBD.
Systematic Review Registration: PROSPERO CRD42023493848.
(© 2024. The Author(s).)
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معلومات مُعتمدة: CXZX202208 Project of Jiangsu Province Traditional Chinese medicine digestive disease medical innovation center
فهرسة مساهمة: Keywords: Inflammatory bowel disease; Mean platelet volume; Meta-analysis; Platelet count; Platelet distribution width; Platelet parameters; Plateletcrit; Systematic review
تواريخ الأحداث: Date Created: 20240703 Date Completed: 20240704 Latest Revision: 20240710
رمز التحديث: 20240710
مُعرف محوري في PubMed: PMC11221001
DOI: 10.1186/s12876-024-03305-9
PMID: 38961334
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-230X
DOI:10.1186/s12876-024-03305-9