دورية أكاديمية
أعرض في EDS

Intensive Surveillance of Porcine-Rhesus Kidney Xenotransplant Using Different Ultrasound Techniques.

التفاصيل البيبلوغرافية
العنوان: Intensive Surveillance of Porcine-Rhesus Kidney Xenotransplant Using Different Ultrasound Techniques.
المؤلفون: Qi R; Department of Urology, Xi-Jing Hospital, Fourth Military Medical University, Xi'an, China., Ma S; Department of Urology, Xi-Jing Hospital, Fourth Military Medical University, Xi'an, China., Han S; Department of Urology, Xi-Jing Hospital, Fourth Military Medical University, Xi'an, China., Wang G; Department of Urology, Xi-Jing Hospital, Fourth Military Medical University, Xi'an, China., Zhang X; Department of Urology, Xi-Jing Hospital, Fourth Military Medical University, Xi'an, China., Liu K; Department of Urology, Xi-Jing Hospital, Fourth Military Medical University, Xi'an, China., Sun Y; Department of Ultrasound, Xi-Jing Hospital, Fourth Military Medical University, Xi'an, China., Gong X; Department of Ultrasound, Xi-Jing Hospital, Fourth Military Medical University, Xi'an, China., Yu M; Department of Ultrasound, Xi-Jing Hospital, Fourth Military Medical University, Xi'an, China., Zhang X; Department of Hepatobiliary Surgery, Xi-Jing Hospital, Fourth Military Medical University, Xi'an, China., Yang X; Department of Urology, Xi-Jing Hospital, Fourth Military Medical University, Xi'an, China., Dou K; Department of Hepatobiliary Surgery, Xi-Jing Hospital, Fourth Military Medical University, Xi'an, China., Qin W; Department of Urology, Xi-Jing Hospital, Fourth Military Medical University, Xi'an, China.
المصدر: Xenotransplantation [Xenotransplantation] 2024 Jul-Aug; Vol. 31 (4), pp. e12873.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Munksgaard International Publishers Country of Publication: Denmark NLM ID: 9438793 Publication Model: Print Cited Medium: Internet ISSN: 1399-3089 (Electronic) Linking ISSN: 0908665X NLM ISO Abbreviation: Xenotransplantation Subsets: MEDLINE
أسماء مطبوعة: Publication: Copenhagen : Munksgaard International Publishers
Original Publication: Copenhagen : Munksgaard, c1994-
مواضيع طبية MeSH: Transplantation, Heterologous*/methods , Kidney Transplantation*/methods , Graft Rejection* , Kidney*/diagnostic imaging , Heterografts* , Macaca mulatta*, Animals ; Swine ; Humans ; Ultrasonography/methods
مستخلص: Background: Significant progress has been made in kidney xenotransplantation in the past few years, and this field is accelerating towards clinical translation. Therefore, surveillance of the xenograft with appropriate tools is of great importance. Ultrasonography has been widely used in kidney allotransplantation and served as an economical and non-invasive method to monitor the allograft. However, questions remain whether the ultrasonographic criteria established for human kidney allograft could also be applied in xenotransplantation.
Methods: In the current study, we established a porcine-rhesus life sustaining kidney xenotransplantation model. The xenograft underwent intensive surveillance using gray-scale, colorful Doppler ultrasound as well as 2D shear wave elastography. The kidney growth, blood perfusion, and cortical stiffness were measured twice a day. These parameters were compared with the clinical data including urine output, chemistry, and pathological findings.
Results: The observation continued for 16 days after transplantation. Decline of urine output and elevated serum creatinine were observed on POD9 and biopsy proven antibody-mediated rejection was seen on the same day. The xenograft underwent substantial growth, with the long axis length increased by 32% and the volume increased by threefold at the end of observation. The resistive index of the xenograft arteries elevated in response to rejection, together with impaired cortical perfusion, while the peak systolic velocity (PSV) was not compromised. The cortical stiffness also increased along with rejection.
Conclusion: In summary, the ultrasound findings of kidney xenograft shared similarities with those in allograft but possessed some unique features. A modified criteria needs to be established for further application of ultrasound in kidney xenotransplantation.
(© 2024 The Author(s). Xenotransplantation published by John Wiley & Sons Ltd.)
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فهرسة مساهمة: Keywords: color Doppler ultrasound; gene‐edited porcine; kidney transplantation; shear wave elastography; xenotransplantation
تواريخ الأحداث: Date Created: 20240704 Date Completed: 20240704 Latest Revision: 20240704
رمز التحديث: 20240704
DOI: 10.1111/xen.12873
PMID: 38961605
قاعدة البيانات: MEDLINE
الوصف
تدمد:1399-3089
DOI:10.1111/xen.12873