دورية أكاديمية
أعرض في EDS

Essential function of transmembrane transcription factor MYRF in promoting transcription of miRNA lin-4 during C. elegans development.

التفاصيل البيبلوغرافية
العنوان: Essential function of transmembrane transcription factor MYRF in promoting transcription of miRNA lin-4 during C. elegans development.
المؤلفون: Xu Z; School of Life Science and Technology, ShanghaiTech University, Shanghai, China., Wang Z; School of Life Science and Technology, ShanghaiTech University, Shanghai, China., Wang L; School of Life Science and Technology, ShanghaiTech University, Shanghai, China., Qi YB; School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
المصدر: ELife [Elife] 2024 Jul 04; Vol. 12. Date of Electronic Publication: 2024 Jul 04.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
مواضيع طبية MeSH: Caenorhabditis elegans*/genetics , Caenorhabditis elegans*/metabolism , Caenorhabditis elegans*/growth & development , Caenorhabditis elegans Proteins*/metabolism , Caenorhabditis elegans Proteins*/genetics , Gene Expression Regulation, Developmental* , MicroRNAs*/metabolism , MicroRNAs*/genetics , Transcription Factors*/metabolism , Transcription Factors*/genetics, Animals ; Promoter Regions, Genetic ; Transcription, Genetic ; Membrane Proteins/metabolism ; Membrane Proteins/genetics ; Cell Nucleus/metabolism
مستخلص: Precise developmental timing control is essential for organism formation and function, but its mechanisms are unclear. In C. elegans , the microRNA lin-4 critically regulates developmental timing by post-transcriptionally downregulating the larval-stage-fate controller LIN-14. However, the mechanisms triggering the activation of lin-4 expression toward the end of the first larval stage remain unknown. We demonstrate that the transmembrane transcription factor MYRF-1 is necessary for lin-4 activation. MYRF-1 is initially localized on the cell membrane, and its increased cleavage and nuclear accumulation coincide with lin-4 expression timing. MYRF-1 regulates lin-4 expression cell-autonomously and hyperactive MYRF-1 can prematurely drive lin-4 expression in embryos and young first-stage larvae. The tandem lin-4 promoter DNA recruits MYRF-1 GFP to form visible loci in the nucleus, suggesting that MYRF-1 directly binds to the lin-4 promoter. Our findings identify a crucial link in understanding developmental timing regulation and establish MYRF-1 as a key regulator of lin-4 expression.
Competing Interests: ZX, ZW, LW, YQ No competing interests declared
(© 2023, Xu et al.)
References: Nature. 1998 Sep 3;395(6697):78-82. (PMID: 9738501)
Nature. 1989 Mar 23;338(6213):313-9. (PMID: 2922060)
Nucleic Acids Res. 2017 May 19;45(9):5112-5125. (PMID: 28160598)
Nature. 1978 Feb 23;271(5647):764-6. (PMID: 625347)
Brain Res. 1979 Mar 16;163(2):195-205. (PMID: 427544)
Cell. 1993 Dec 3;75(5):855-62. (PMID: 8252622)
Mol Syst Biol. 2020 Jul;16(7):e9498. (PMID: 32687264)
Dev Cell. 2017 Apr 24;41(2):180-194.e7. (PMID: 28441531)
J Neurosci. 2012 Sep 5;32(36):12528-42. (PMID: 22956843)
Elife. 2021 May 05;10:. (PMID: 33950834)
Curr Biol. 2021 Feb 22;31(4):809-826.e6. (PMID: 33357451)
PLoS Genet. 2014 Jun 19;10(6):e1004426. (PMID: 24945623)
Development. 2012 Apr;139(7):1247-57. (PMID: 22357933)
Dev Cell. 2023 Nov 20;58(22):2563-2579.e8. (PMID: 37643611)
Curr Biol. 2006 Apr 18;16(8):780-5. (PMID: 16631585)
Annu Rev Genet. 1997;31:611-34. (PMID: 9442909)
Development. 2015 Dec 15;142(24):4374-84. (PMID: 26552885)
Dev Biol. 2012 Apr 15;364(2):202-13. (PMID: 22342905)
Dev Biol. 2010 Dec 15;348(2):210-21. (PMID: 20937268)
PLoS Biol. 2013;11(8):e1001625. (PMID: 23966833)
Genome Biol. 2014;15(12):550. (PMID: 25516281)
Genetics. 2018 Jul;209(3):651-673. (PMID: 29967059)
Development. 2014 Apr;141(7):1580-8. (PMID: 24598163)
Semin Cell Dev Biol. 2023 Jun;142:67-80. (PMID: 35688774)
Glia. 2016 Dec;64(12):2120-2132. (PMID: 27532821)
Cell. 1993 Dec 3;75(5):843-54. (PMID: 8252621)
Dev Biol. 1999 Dec 15;216(2):671-80. (PMID: 10642801)
Trends Genet. 1994 Apr;10(4):123-7. (PMID: 8029828)
Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15450-5. (PMID: 25319259)
Mol Cell Biol. 1997 Apr;17(4):2301-11. (PMID: 9121480)
J Neurobiol. 1990 Oct;21(7):1072-84. (PMID: 1979610)
Genetics. 2023 Feb 9;223(2):. (PMID: 36630525)
Philos Trans R Soc Lond B Biol Sci. 1986 Nov 12;314(1165):1-340. (PMID: 22462104)
Genetics. 1974 May;77(1):71-94. (PMID: 4366476)
Elife. 2024 Jul 04;12:. (PMID: 38963411)
PLoS Biol. 2013;11(8):e1001624. (PMID: 23966832)
Nat Genet. 2013 Nov;45(11):1337-44. (PMID: 24036951)
Science. 1984 Oct 26;226(4673):409-16. (PMID: 6494891)
Dev Biol. 2014 Jun 15;390(2):126-35. (PMID: 24699545)
Genetics. 2014 Nov;198(3):837-46. (PMID: 25161212)
Nat Methods. 2014 May;11(5):529-34. (PMID: 24820376)
Curr Top Dev Biol. 2021;144:19-43. (PMID: 33992153)
Nature. 2015 Jul 2;523(7558):83-7. (PMID: 26083757)
Curr Top Dev Biol. 2013;105:153-80. (PMID: 23962842)
Cell. 2009 Jul 10;138(1):172-85. (PMID: 19596243)
Dev Biol. 1999 Jun 1;210(1):87-95. (PMID: 10364429)
Genes Dev. 2008 Sep 15;22(18):2520-34. (PMID: 18794349)
PLoS Genet. 2014 Jul 17;10(7):e1004486. (PMID: 25032706)
BMC Dev Biol. 2013 May 17;13:21. (PMID: 23682709)
Genetics. 2020 Dec;216(4):837-878. (PMID: 33268389)
Dev Biol. 2011 Dec 15;360(2):297-309. (PMID: 21989027)
Philos Trans R Soc Lond B Biol Sci. 1976 Aug 10;275(938):327-48. (PMID: 8806)
Mol Cell. 2014 Feb 6;53(3):380-92. (PMID: 24440504)
Nature. 2021 Dec;600(7887):93-99. (PMID: 34759317)
معلومات مُعتمدة: P40 OD010440 United States OD NIH HHS; 31900397 National Science Foundation of China
فهرسة مساهمة: Keywords: C. elegans; DD synaptic rewiring; MYRF-2; PAN-1; dauer; developmental biology; intramolecular chaperone; self-cleavage
سلسلة جزيئية: Dryad 10.5061/dryad.tqjq2bw71
GEO GSE262766
المشرفين على المادة: 0 (Caenorhabditis elegans Proteins)
0 (MicroRNAs)
0 (Transcription Factors)
0 (lin-4 microRNA, C elegans)
0 (Membrane Proteins)
تواريخ الأحداث: Date Created: 20240704 Date Completed: 20240704 Latest Revision: 20240729
رمز التحديث: 20240729
مُعرف محوري في PubMed: PMC11223767
DOI: 10.7554/eLife.89903
PMID: 38963411
قاعدة البيانات: MEDLINE
الوصف
تدمد:2050-084X
DOI:10.7554/eLife.89903