دورية أكاديمية
أعرض في EDS

Inflammatory markers in relation to maternal lifestyle and adverse pregnancy outcomes in twin pregnancies.

التفاصيل البيبلوغرافية
العنوان: Inflammatory markers in relation to maternal lifestyle and adverse pregnancy outcomes in twin pregnancies.
المؤلفون: Christiansen CH; Department of Obstetrics, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark., Kirk M; Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Valdemar Hansens Vej 13, 2600 Glostrup, Denmark; Translational Research Centre, Nordstjernevej 42-44, Rigshospitalet, 2600 Glostrup, Denmark., Worda K; Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria., Hegaard HK; Department of Obstetrics, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark; Institute of Clinical Medicine, Faculty of Health Sciences and Medicine, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark., Rode L; Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Valdemar Hansens Vej 13, 2600 Glostrup, Denmark; Translational Research Centre, Nordstjernevej 42-44, Rigshospitalet, 2600 Glostrup, Denmark. Electronic address: line.rode@regionh.dk.
مؤلفون مشاركون: Collaborators – The PREDICT-group
المصدر: Journal of reproductive immunology [J Reprod Immunol] 2024 Aug; Vol. 164, pp. 104286. Date of Electronic Publication: 2024 Jun 24.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Ireland NLM ID: 8001906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7603 (Electronic) Linking ISSN: 01650378 NLM ISO Abbreviation: J Reprod Immunol Subsets: MEDLINE
أسماء مطبوعة: Publication: Limerick : Elsevier/North-Holland Biomedical Press
Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press.
مواضيع طبية MeSH: Pregnancy, Twin*/blood , Pregnancy, Twin*/immunology , Biomarkers*/blood , Pregnancy Outcome* , Diabetes, Gestational*/immunology , Diabetes, Gestational*/blood , Inflammation*/immunology , Inflammation*/blood, Humans ; Female ; Pregnancy ; Adult ; Life Style ; Pre-Eclampsia/blood ; Pre-Eclampsia/immunology ; Pre-Eclampsia/epidemiology ; Smoking/adverse effects ; Smoking/blood ; Interleukin-8/blood ; C-Reactive Protein/analysis ; Chemokine CCL2/blood ; Inflammation Mediators/blood ; Inflammation Mediators/metabolism ; Body Mass Index ; Pregnancy Complications/immunology ; Pregnancy Complications/blood
مستخلص: It is well known that inflammatory markers play an important role in the development and maintenance of healthy pregnancies. However, the literature regarding inflammation in relation to lifestyle and adverse pregnancy outcomes in twin pregnancies is remarkably uncovered. Therefore, this study aimed at evaluating the concentration of inflammatory markers in dried capillary blood spot samples from 523 women with twin pregnancies, included at a median gestational age of 21+1 weeks. The relationship between inflammatory markers and maternal lifestyle (current smoking status and pre-pregnancy body mass index) in addition to adverse pregnancy outcomes (preeclampsia, gestational diabetes mellitus, and small for gestational age) was analyzed. The study showed that active smoking at inclusion was associated with an elevated concentration of interleukin-8. Furthermore, maternal obesity was associated with an elevated concentration of C-reactive protein and monocyte chemoattractant protein-1. Analysis of the data showed no statistically significant variations in the concentration of the assessed inflammatory markers for neither preeclampsia, gestational diabetes mellitus, nor small for gestational age. The current study promotes future research on the pathophysiology of twin pregnancies in relation to adverse pregnancy outcomes, as the literature within the area remains scarce.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Investigator: H Larsen, Department of Obstetrics and Gynecology, Aalborg University Hospital, Denmark.; A Holmskov, Department of Obstetrics and Gynecology, Viborg Hospital, Denmark.; KR Andreasen, Department of Obstetrics and Gynecology, Copenhagen University Hospital - Hvidovre, Denmark.; N Uldbjerg, Department of Obstetrics and Gynecology, Aarhus University Hospital, Denmark; Department of Clinical Medicine, Aarhus University, Denmark.; J Ramb, Department of Obstetrics and Gynecology, Sønderborg Hospital, Denmark; Department of Obstetrics and Gynecology, Helgelands Hospital, Mo i Rana, Norway.; L Sperling, Department of Obstetrics and Gynecology, Copenhagen University Hospital - Herlev, Denmark; Department of Obstetrics and Gynecology, Odense University Hospital, Denmark.; S Hinterberger, Department of Obstetrics and Gynecology, General Hospital of Klagenfurt, Austria.; L Krebs, Department of Obstetrics and Gynecology, Copenhagen University Hospital - Hvidovre, Denmark; Department of Obstetrics and Gynecology, Holbæk Hospital, Denmark.; H Zingenberg, Department of Obstetrics and Gynecology, Copenhagen University Hospital - Herlev, Denmark; Department of Obstetrics and Gynecology, Glostrup Hospital, Denmark.; EC Weiss, Department of Obstetrics and Gynecology, Medical University of Graz, Austria.; I Strobl, Department of Obstetrics and Gynecology, Medical University of Innsbruck, Austria.; L Laursen, Department of Obstetrics and Gynecology, Aarhus University Hospital, Denmark; Department of Obstetrics and Gynecology, Odense University Hospital, Denmark.; JT Christensen, Department of Obstetrics and Gynecology, Kolding Hospital, Denmark.; K Skogstrand, Department of Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.; I Vogel, Department of Obstetrics and Gynecology, Aarhus University Hospital, Denmark; Department of Clinical Medicine, Aarhus University, Denmark.; E Krampl-Bettelheim, FetoMed, Center for Fetal Medicine, Vienna, Austria.; A Tabor, Department of Obstetrics, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark.
Keywords: Gestational diabetes; Inflammation; Preeclampsia; Small for gestational age; Twin pregnancy
المشرفين على المادة: 0 (Biomarkers)
0 (Interleukin-8)
9007-41-4 (C-Reactive Protein)
0 (Chemokine CCL2)
0 (Inflammation Mediators)
تواريخ الأحداث: Date Created: 20240704 Date Completed: 20240725 Latest Revision: 20240725
رمز التحديث: 20240726
DOI: 10.1016/j.jri.2024.104286
PMID: 38964134
قاعدة البيانات: MEDLINE
الوصف
تدمد:1872-7603
DOI:10.1016/j.jri.2024.104286