دورية أكاديمية
Deciphering molecular mechanisms underlying the inhibition of β-glucuronidase by xanthones from Centaurium spicatum.
العنوان: | Deciphering molecular mechanisms underlying the inhibition of β-glucuronidase by xanthones from Centaurium spicatum. |
---|---|
المؤلفون: | Kamel EM; Chemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef 62514, Egypt. Electronic address: emad.abdelhameed@science.bsu.edu.eg., Alqhtani HA; Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. BOX 84428, Riyadh 11671, Saudi Arabia., Bin-Jumah M; Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. BOX 84428, Riyadh 11671, Saudi Arabia., Rudayni HA; Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University, Riyadh 11623, Saudi Arabia., El-Bassuony AA; Chemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef 62514, Egypt., Mokhtar Lamsabhi A; Departamento de Química, Módulo 13, Universidad Autónoma de Madrid, Campus de Excelencia UAM-CSIC Cantoblanco, 28049 Madrid, Spain; Institute for Advanced Research in Chemical Sciences (IAdChem), Universidad Autónoma de Madrid, 28049 Madrid, Spain. |
المصدر: | Bioorganic chemistry [Bioorg Chem] 2024 Sep; Vol. 150, pp. 107609. Date of Electronic Publication: 2024 Jul 02. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: New York, London, Academic Press. |
مواضيع طبية MeSH: | Glucuronidase*/antagonists & inhibitors , Glucuronidase*/metabolism , Xanthones*/chemistry , Xanthones*/pharmacology , Enzyme Inhibitors*/pharmacology , Enzyme Inhibitors*/chemistry , Molecular Docking Simulation*, Dose-Response Relationship, Drug ; Molecular Dynamics Simulation ; Molecular Structure ; Structure-Activity Relationship ; Humans ; Glycoproteins |
مستخلص: | Herein, we scrutinized the inhibitory potential of five xanthones and a flavonoid, sourced from Centaurium spicatum, against β-glucuronidase activity. The results showed that gentisin and azaleatin emerged as the most potent inhibitors, with significantly lower IC Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024 Elsevier Inc. All rights reserved.) |
فهرسة مساهمة: | Keywords: Enzyme kinetics; Molecular docking; Molecular dynamics simulations; Xanthones; β-glucuronidase |
المشرفين على المادة: | EC 3.2.1.31 (Glucuronidase) 0 (Xanthones) 0 (Enzyme Inhibitors) 0 (beta-glucuronidase inhibitor) 0 (Glycoproteins) |
تواريخ الأحداث: | Date Created: 20240704 Date Completed: 20240719 Latest Revision: 20240722 |
رمز التحديث: | 20240722 |
DOI: | 10.1016/j.bioorg.2024.107609 |
PMID: | 38964145 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1090-2120 |
---|---|
DOI: | 10.1016/j.bioorg.2024.107609 |