دورية أكاديمية
Systematic evaluation and meta-analysis of Flunarizine Hydrochloride combined with traditional Chinese medicine decoction in the treatment of migraine headaches.
| العنوان: | Systematic evaluation and meta-analysis of Flunarizine Hydrochloride combined with traditional Chinese medicine decoction in the treatment of migraine headaches. |
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| المؤلفون: | Fan D; Department of Encephalopathy, The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, Jilin, China. Electronic address: fandan1790@163.com., Leng W; Department of Encephalopathy, The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, Jilin, China., Zhang L; Department of Encephalopathy, The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, Jilin, China. |
| المصدر: | Clinics (Sao Paulo, Brazil) [Clinics (Sao Paulo)] 2024 Jul 03; Vol. 79, pp. 100431. Date of Electronic Publication: 2024 Jul 03 (Print Publication: 2024). |
| نوع المنشور: | Journal Article; Meta-Analysis; Systematic Review; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 101244734 Publication Model: eCollection Cited Medium: Internet ISSN: 1980-5322 (Electronic) Linking ISSN: 18075932 NLM ISO Abbreviation: Clinics (Sao Paulo) Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2022- : [New York] : Elsevier Original Publication: São Paulo, SP : Hospital das Clínicas, Faculty of Medicine, University of São Paulo, [2005]- |
| مواضيع طبية MeSH: | Flunarizine*/therapeutic use , Migraine Disorders*/drug therapy , Drugs, Chinese Herbal*/therapeutic use , Randomized Controlled Trials as Topic* , Medicine, Chinese Traditional*/methods, Humans ; Treatment Outcome ; Drug Therapy, Combination |
| مستخلص: | Objectives: To systematically evaluate the efficacy and superiority of Flunarizine Hydrochloride when combined with Traditional Chinese Medicine (TCM) Decoctions in treating migraine headaches. Method: The authors conducted a comprehensive search for clinical Randomized Controlled Trials (RCTs) investigating the combination of Flunarizine Hydrochloride with Chinese herbal decoctions in treating migraines. The databases searched included CNKI, VIP, Wanfang, PubMed, WOI, Cochrane Library, and Embase, covering the period from January 1, 2019, to November 10, 2023. Two independent researchers meticulously screened, extracted, and assessed the relevant data, employing the Revman 5.3 software for meta-analysis. Results: The meta-analysis revealed that, in comparison to Flunarizine Hydrochloride used in isolation, the combination with Chinese herbal decoctions markedly enhanced the effective rate (RR = 1.26, 95 % CI [1.18, 1.34], p < 0.0001). Moreover, significant improvements were observed in the TCM symptom score (MD = 4.97, 95 % CI [-6.74, -3.19], p < 0.00001). The observation group demonstrated a statistically significant improvement in endothelin levels compared to the control group (I 2 = 85 %, MD = -13.66, 95 % CI [-17.87, -9.45], p = 0.0001). The observation group showed a significant reduction in NRS scores compared to the control group, indicating better outcomes (I 2 = 95 %, MD = -2.11, 95 % CI [-3.09, -1.12], p < 0.0001). The observation group was superior to the control group in terms of the reduction in the number of episodes (I 2 = 63 %, MD = -1.16, 95 % CI [-1.45, -0.87], p = 0.007). Conclusions: The confluence of Flunarizine Hydrochloride with traditional Chinese medicine decoctions in treating migraine patients demonstrated substantial clinical efficacy and improvement in TCM symptom score over the use of Flunarizine Hydrochloride alone. Competing Interests: Conflicts of interest The authors declare no conflicts of interest. (Copyright © 2024 HCFMUSP. Published by Elsevier España, S.L.U. All rights reserved.) |
| References: | Med Clin North Am. 2019 Mar;103(2):215-233. (PMID: 30704678) Phytother Res. 2020 Oct;34(10):2493-2517. (PMID: 32310327) Med Sci Monit. 2016 Sep 12;22:3229-37. (PMID: 27618395) Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4687-92. (PMID: 11287655) CNS Drugs. 2019 May;33(5):399-415. (PMID: 30627973) Cephalalgia. 2020 Sep;40(10):1026-1044. (PMID: 32722936) |
| فهرسة مساهمة: | Keywords: Chinese medicine symptom score; Flunarizine Hydrochloride; Meta-analysis; Migraine; Traditional Chinese medicine decoction |
| المشرفين على المادة: | R7PLA2DM0J (Flunarizine) 0 (Drugs, Chinese Herbal) |
| تواريخ الأحداث: | Date Created: 20240704 Date Completed: 20240709 Latest Revision: 20240728 |
| رمز التحديث: | 20240728 |
| مُعرف محوري في PubMed: | PMC11278533 |
| DOI: | 10.1016/j.clinsp.2024.100431 |
| PMID: | 38964249 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1980-5322 |
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| DOI: | 10.1016/j.clinsp.2024.100431 |