دورية أكاديمية
أعرض في EDS

Vitamin D levels in couples undergoing in vitro fertilization treatment: lack of association with embryo quality or pregnancy rates.

التفاصيل البيبلوغرافية
العنوان: Vitamin D levels in couples undergoing in vitro fertilization treatment: lack of association with embryo quality or pregnancy rates.
المؤلفون: Antunes RA; Department of Gynecology of the Clementino Fraga Filho Universitary Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil; Human Reproduction Center, Fertipraxis, Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address: robertoantunes@fertipraxis.com.br., Souza MDCB; Human Reproduction Center, Fertipraxis, Rio de Janeiro, Rio de Janeiro, Brazil., Souza MM; Human Reproduction Center, Fertipraxis, Rio de Janeiro, Rio de Janeiro, Brazil., Melo GPS; Department of Gynecology of the Clementino Fraga Filho Universitary Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil., Melo BML; Department of Gynecology of the Clementino Fraga Filho Universitary Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil; Human Reproduction Center, Fertipraxis, Rio de Janeiro, Rio de Janeiro, Brazil., Mancebo ACA; Human Reproduction Center, Fertipraxis, Rio de Janeiro, Rio de Janeiro, Brazil., Conceição FL; Department of Endocrinology of the Clementino Fraga Filho Universitary Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil., Ortiga-Carvalho TM; Translational Endocrinology Lab of the Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
المصدر: Fertility and sterility [Fertil Steril] 2024 Jul 02. Date of Electronic Publication: 2024 Jul 02.
Publication Model: Ahead of Print
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier for the American Society for Reproductive Medicine Country of Publication: United States NLM ID: 0372772 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1556-5653 (Electronic) Linking ISSN: 00150282 NLM ISO Abbreviation: Fertil Steril Subsets: MEDLINE
أسماء مطبوعة: Publication: New York. NY : Elsevier for the American Society for Reproductive Medicine
Original Publication: New York, Hoeber.
مستخلص: Objective: To investigate the potential impact of vitamin D (VD) serum levels on couples going through in vitro fertilization treatment in terms of embryo quality and pregnancy rates.
Design: A retrospective cohort study.
Setting: A private human reproduction center.
Patient(s): A total of 267 couples underwent intracytoplasmic sperm injections between January 2017 and March 2019.
Intervention(s): The couples were categorized into four groups on the basis of 25-hydroxy VD (25OHD) levels measured at the beginning of the stimulation protocol: group 1 with 25OHD levels ≥30 ng/mL for both women and men; group 2 with 25OHD levels <30 ng/mL for both; group 3 women with 25OHD levels <30 ng/mL and men with 25OHD levels ≥30 ng/mL; and group 4 with women with 25OHD level ≥30 ng/mL and men with 25OHD level <30 ng/mL.
Main Outcome Measure(s): We consider the quantity and quality of embryos during the cleavage as well as blastocyst stages as primary outcomes. Correspondingly, the clinical pregnancy rate (CPR) was regarded as a secondary outcome.
Result(s): Our findings revealed no significant correlations between the studied VD groups and the evaluated outcomes. This includes the quantity and quality of embryos during the cleavage and blastocyst stages, as well as the CPR. Primary analysis revealed a small but statistically significant difference in the duration of controlled ovarian stimulation between group 1 and group 2 (95% confidence interval, 0.07-3.04) and between group 1 and group 3 (95% confidence interval, 0.05-3.23).
Conclusion(s): The present study found no correlation between the studied VD levels and the quantity as well as quality of cleavage or blastocyst stage embryos, nor did it show any impact on CPRs. Further well-designed, prospective studies are warranted to determine whether and how vitamin D affects reproductive outcomes.
Competing Interests: Declaration of Interests R.D.A.A. receives eventual honoraria from Abbott, Ferring Pharmaceuticals, Besins Healthcare, and Organon for medical conferences, medical board participation, and has been sponsored to attend medical congresses (European Society of Human Reproduction and Embryology [ESHRE] and American Society for Reproductive Medicine [ASRM] annual congress by Ferring Pharmaceutical, ESHRE 2023 annual congress by Organon, and ESHRE 2024 annual conference by Besins Healthcare and Ferring Pharmaceuticals); Brazilian Society of Assisted Reproduction - SBRA – Director; Rio de Janeiro Association of Gynecology and Obstetrics - SGORJ – Director; Latin American Network of Assisted Reproduction - REDLARA - Coordinator of the Postgraduation of Assisted Reproduction for Physicians – PEC Online. M.D.C.B.S. receives eventual honoraria from Abbott, Ferring Pharmaceuticals, Merck, and Exeltis for medical conferences and medical board participation, and has been sponsored to attend medical congresses (ESHRE 2023 and 2024) from Ferring Pharmaceuticals. M.M.S. has nothing to disclose. G.P.S.M. has nothing to disclose. B.M.L.M. has nothing to disclose. A.C.A.M. has nothing to disclose. F.L.C. has nothing to disclose. T.M.O.-C. has received two research grants from FAPERJ (Carlos Chagas Filho Foundation for Research Support in the State of Rio de Janeiro, Brazil) and CNPq (Brazilian National Council for Scientific and Technological Development).
(Copyright © 2024 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Vitamin D; clinical pregnancy rates; embryo quality; infertility; in vitro fertilization
تواريخ الأحداث: Date Created: 20240704 Latest Revision: 20240808
رمز التحديث: 20240808
DOI: 10.1016/j.fertnstert.2024.06.023
PMID: 38964589
قاعدة البيانات: MEDLINE
الوصف
تدمد:1556-5653
DOI:10.1016/j.fertnstert.2024.06.023