دورية أكاديمية
[Gastric and colic digestive localizations of myeloma; 3 case studies and literature review].
| العنوان: | [Gastric and colic digestive localizations of myeloma; 3 case studies and literature review]. |
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| عنوان ترانسليتريتد: | Localisations digestives gastriques et coliques de myélomes ; étude de 3 cas et revue de la littérature. |
| المؤلفون: | Mathieu C; Service d'anatomie et cytologie pathologiques du CHU d'Amiens, 1, place Victor-Pauchet, Amiens, France. Electronic address: camille.mathieu067@gmail.com., Le Mouel JP; Service d'hépato-gastro-entérologie du CHU d'Amiens, 1, rue du Professeur-Christian-Cabrol, Amiens, France., Moslemi A; Service d'anatomie et cytologie pathologiques du CHU d'Amiens, 1, place Victor-Pauchet, Amiens, France., Morel P; Service d'hématologie du CHU Amiens, 1, rue du Professeur-Christian-Cabrol, Amiens, France., Tesson JR; Service d'anatomie et cytologie pathologiques du CHU d'Amiens, 1, place Victor-Pauchet, Amiens, France., Chatelain D; Service d'anatomie et cytologie pathologiques du CHU d'Amiens, 1, place Victor-Pauchet, Amiens, France. |
| المصدر: | Annales de pathologie [Ann Pathol] 2024 Jul 03. Date of Electronic Publication: 2024 Jul 03. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | French |
| بيانات الدورية: | Publisher: Masson Country of Publication: France NLM ID: 8106337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0242-6498 (Print) Linking ISSN: 02426498 NLM ISO Abbreviation: Ann Pathol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Paris ; New York : Masson, c1981- |
| مستخلص: | Multiple myeloma is a malignant plasma cell proliferation located in the bone marrow and bones. It can secondarily manifest with extraosseous involvement, but the gastro-intestinal tract locations are rare. We report 3 cases of gastric and colonic localizations of myeloma in two males and one female, aged 66, 71 and 77years. Multiple myeloma had been diagnosed 1 to 7years before. Digestive symptoms were epigastric pain, rectal bleeding or an obstructive syndrome. Endoscopy revealed ulcerated and budding tumors in the stomach, and nodular pseudo-polypoid tumor formations or an ulcerated erythematous area in the colon. Histopathological examination of the biopsies showed a diffuse tumor cell proliferation in the lamina propria composed of cells with a plasmacytoid or plasmablastic appearance, expressing plasma cell markers such as CD138 on immunohistochemistry. The 3 patients died in the weeks following the diagnosis. The prognosis of digestive localizations of multiple myeloma remains very poor despite new therapies. In the presence of any digestive symptoms in these patients with multiple myeloma, more systematic endoscopy may allow an earlier diagnosis and the implementation of more effective therapies. (Copyright © 2024 Elsevier Masson SAS. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Colonic tumors; Gastric tumors; Immunohistochemistry; Immunohistochimie; Multiple myeloma; Myélome multiple; Tumeurs coliques; Tumeurs gastriques |
| تواريخ الأحداث: | Date Created: 20240704 Latest Revision: 20240704 |
| رمز التحديث: | 20240705 |
| DOI: | 10.1016/j.annpat.2024.06.007 |
| PMID: | 38965025 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0242-6498 |
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| DOI: | 10.1016/j.annpat.2024.06.007 |