دورية أكاديمية
Frequency of Duffy, Kidd, Lewis, and Rh Blood Group Antigens and Phenotypes Among Donors in the Al-Ahsa Region, Saudi Arabia.
| العنوان: | Frequency of Duffy, Kidd, Lewis, and Rh Blood Group Antigens and Phenotypes Among Donors in the Al-Ahsa Region, Saudi Arabia. |
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| المؤلفون: | Kuriri FA, Ahmed A, Alhumud F, Alanazi F, Abdalhabib EK |
| المصدر: | Clinical laboratory [Clin Lab] 2024 Jul 01; Vol. 70 (7). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Clinical Laboratory Publications Country of Publication: Germany NLM ID: 9705611 Publication Model: Print Cited Medium: Internet ISSN: 1433-6510 (Print) Linking ISSN: 14336510 NLM ISO Abbreviation: Clin Lab Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2010- : Mainz : Clinical Laboratory Publications Original Publication: Heidelberg : Verlag Klinisches Labor, [1997- |
| مواضيع طبية MeSH: | Phenotype* , Duffy Blood-Group System*/genetics , Blood Group Antigens*/immunology , Blood Group Antigens*/genetics, Humans ; Saudi Arabia/epidemiology ; Lewis Blood Group Antigens/immunology ; Lewis Blood Group Antigens/genetics ; Blood Donors/statistics & numerical data ; Rh-Hr Blood-Group System/genetics ; Rh-Hr Blood-Group System/immunology ; Kidd Blood-Group System/genetics ; Kidd Blood-Group System/immunology ; Male ; Blood Grouping and Crossmatching/methods ; Female |
| مستخلص: | Background: In Al-Ahsa, Saudi Arabia, the high consanguinity rates contribute to the prevalence of inherited hemoglobinopathies such as sickle cell disease and thalassemia, which frequently require blood transfusions. These transfusions carry the risk of alloimmunization, necessitating a precise blood component matching to mitigate health risks. Local antigen frequency data is vital for optimizing transfusion practices and enhancing the safety of these medical procedures for the Al-Ahsa population. Methods: This study investigated the distribution of Duffy, Kidd, Lewis, and Rh blood group antigens in 1,549 individuals from the region; comparing the frequencies with global data. Results: Serological analyses revealed a high prevalence of the Fy(a+b-) and Jk(a+b+) phenotypes in the Duffy and Kidd blood groups, respectively, with Jk(a-b-) being notably scarce. The Lewis blood group exhibited a significant presence of Le(a-b+) and Le(a+b-) phenotypes, whereas Le(a+b+) was less common. In the Rh system, the D antigen was most prevalent, with other antigens following in descending order of frequency. Conclusions: The study underscores the regional variation in antigen frequencies, emphasizing the need for local blood banks to adapt their screening and matching practices to mitigate the risk of alloimmunization and enhance transfusion safety. These findings are pivotal for refining transfusion strategies and understanding the immunohematology landscape in Al-Ahsa. |
| المشرفين على المادة: | 0 (Duffy Blood-Group System) 0 (Blood Group Antigens) 0 (Lewis Blood Group Antigens) 0 (Rh-Hr Blood-Group System) 0 (Kidd Blood-Group System) |
| تواريخ الأحداث: | Date Created: 20240705 Date Completed: 20240705 Latest Revision: 20240705 |
| رمز التحديث: | 20240705 |
| DOI: | 10.7754/Clin.Lab.2024.240104 |
| PMID: | 38965955 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1433-6510 |
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| DOI: | 10.7754/Clin.Lab.2024.240104 |