دورية أكاديمية
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Behavioral, biochemical, histopathological evaluation and gene expression of brain injury induced by nanoceria injected intranasal or intraperitoneal in mice.

التفاصيل البيبلوغرافية
العنوان: Behavioral, biochemical, histopathological evaluation and gene expression of brain injury induced by nanoceria injected intranasal or intraperitoneal in mice.
المؤلفون: Saeed HE; Department of Clinical Pathology, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, 62511, Egypt., Ibrahim RR; Department of Animal and Poultry Management and Wealth Development, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, 62511, Egypt., Kamel S; Department of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Cairo University, Cairo, 12211, Egypt., El-Nahass ES; Department of Veterinary Pathology, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, 62511, Egypt., Khalifa AG; Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, 62511, Egypt.
المصدر: Toxicology research [Toxicol Res (Camb)] 2024 Jul 03; Vol. 13 (4), pp. tfae095. Date of Electronic Publication: 2024 Jul 03 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 101587950 Publication Model: eCollection Cited Medium: Print ISSN: 2045-452X (Print) Linking ISSN: 2045452X NLM ISO Abbreviation: Toxicol Res (Camb) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2020- : Oxford : Oxford University Press
Original Publication: Cambridge : RSC Publishing
مستخلص: Background: Nanotechnology has shown a remarkable progress nevertheless, there is a growing concern about probable neurotoxic and neurodegenerative effects due to NPs exposure. Various toxicological and epidemiological studies reported that the brain is a main target for ultrafine particles. Brain inflammation is considered as a possible mechanism that can participate to neurotoxic and neurodegenerative effects. Whether nanoparticles (NPs) may produce neurotoxicity and promote neurodegenerative is largely unstudied. The present study was done to investigate whether intranasal and intra-peritoneal exposure to cerium oxide nanoparticles (CeO2NPs, nanoceria (NC)) could cause neurotoxicity and neurodegenerative changes in the brain tissue through conducting some behavioral tests, biochemical evaluation, histopathological examinations of brain hippocampus and gene expressions.
Method: Fifteen mice were separated into 3 equal groups. In group (I) "control group", mice were received distilled water orally and kept as a control group. Mice in the group (II) "NC I/P group" were injected i.p with cerium oxide nanoparticles at a dose of 40 mg/kg b.wt, twice weekly for 3 weeks. In group (III) "NC I/N group" mice were received nanoceria intranasally (40 mg/kg b.wt), twice weekly for 3 weeks.
Results: Exposure to nanceria resulted in oxidative damage in brain tissue, a significant increase in malondialdehyde (MDA) and acetylcholinestrase (AchE) levels, significant decrease in reduced glutathione (GSH) concentration, upregulation in the apoptosis-related genes (c-Jun: c-Jun N-terminal kinases (JNKs), c-Fos: Fos protooncogene, AP-1 transcription factor subunit, c-Myc: c-myelocytomatosis oncogene product or MYC protooncogene, bHLH transcription factor), locomotor and cognitive impairment in mice but the effect was more obvious when nanoceria adminstred intraperitoneally.
Conculsion: Nanoceria cause oxidative damage in brain tissue of mice when adminstred nanoceria intraperitoneally more than those received nanoceria intranasal.
(© The Author(s) 2024. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)
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فهرسة مساهمة: Keywords: behavioral; biochemical; gene expression; histopathological; nanoceria; neurotoxicity
تواريخ الأحداث: Date Created: 20240705 Latest Revision: 20240706
رمز التحديث: 20240706
مُعرف محوري في PubMed: PMC11221883
DOI: 10.1093/toxres/tfae095
PMID: 38966091
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-452X
DOI:10.1093/toxres/tfae095