دورية أكاديمية
أعرض في EDS

Hemophagocytic Lymphohistiocytosis: A Case Series From a Tertiary State Hospital in Malaysia and a Review of Current Literature.

التفاصيل البيبلوغرافية
العنوان: Hemophagocytic Lymphohistiocytosis: A Case Series From a Tertiary State Hospital in Malaysia and a Review of Current Literature.
المؤلفون: Khaw JY; Medical Department, Hospital Melaka, Melaka, MYS., Gan WF; Infectious Diseases Department, Hospital Melaka, Melaka, MYS., Chong HC; Medical Department, Hospital Melaka, Melaka, MYS., Lau NS; Hematology Department, Hospital Ampang, Ampang, MYS., Wan Yusof WA; Pathology and Laboratory Medicine Department, Hospital Melaka, Melaka, MYS.
المصدر: Cureus [Cureus] 2024 Jun 04; Vol. 16 (6), pp. e61636. Date of Electronic Publication: 2024 Jun 04 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cureus, Inc Country of Publication: United States NLM ID: 101596737 Publication Model: eCollection Cited Medium: Print ISSN: 2168-8184 (Print) Linking ISSN: 21688184 NLM ISO Abbreviation: Cureus Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Palo Alto, CA : Cureus, Inc.
مستخلص: Introduction: Hemophagocytic lymphohistiocytosis (HLH) is a lethal emergency. Delays in diagnosis and treatment are detrimental to the health of patients. Classical clinical manifestations of HLH include fever, cytopenia, liver dysfunction, central nervous system involvement, and coagulopathy.
Methods: We report seven cases of secondary HLH in adults diagnosed from a total of 1200 bone marrow aspiration and trephine biopsy (BMAT) examinations in our center, with various presentations and underlying triggers including infection, malignancy, and autoimmune disease.
Results: HLH can present with non-specific signs and symptoms.
Conclusion: Early recognition of HLH is crucial to enable the commencement of therapy as early as possible to prevent mortality resulting from multi-organ failure.
Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.
(Copyright © 2024, Khaw et al.)
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فهرسة مساهمة: Keywords: adult onset still's disease; bmat; hlh; hscore; lymphoma
تواريخ الأحداث: Date Created: 20240705 Latest Revision: 20240706
رمز التحديث: 20240706
مُعرف محوري في PubMed: PMC11223718
DOI: 10.7759/cureus.61636
PMID: 38966453
قاعدة البيانات: MEDLINE
الوصف
تدمد:2168-8184
DOI:10.7759/cureus.61636