دورية أكاديمية
Insular and limbic abnormal functional connectivity in early-stage Parkinson's disease patients with autonomic dysfunction.
| العنوان: | Insular and limbic abnormal functional connectivity in early-stage Parkinson's disease patients with autonomic dysfunction. |
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| المؤلفون: | Conti M; Neurology Unit, Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier 1, 00133 Rome, Italy., Garasto E; Neurology Unit, Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier 1, 00133 Rome, Italy., Bovenzi R; Neurology Unit, Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier 1, 00133 Rome, Italy., Ferrari V; Neurology Unit, Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier 1, 00133 Rome, Italy., Mercuri NB; Neurology Unit, Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier 1, 00133 Rome, Italy., Di Giuliano F; Neuroradiology Unit, Department of Biomedicine and Prevention, University of Rome 'Tor Vergata', Via Montpellier 1, 00133 Rome, Italy., Cerroni R; Neurology Unit, Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier 1, 00133 Rome, Italy.; UOSD Parkinson Centre, Tor Vergata University Hospital, Viale Oxford 81, 00133 Rome, Italy., Pierantozzi M; Neurology Unit, Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier 1, 00133 Rome, Italy., Schirinzi T; Neurology Unit, Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier 1, 00133 Rome, Italy., Stefani A; Neurology Unit, Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier 1, 00133 Rome, Italy.; UOSD Parkinson Centre, Tor Vergata University Hospital, Viale Oxford 81, 00133 Rome, Italy., Rocchi C; Neurology Unit, Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier 1, 00133 Rome, Italy. |
| المصدر: | Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2024 Jul 03; Vol. 34 (7). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 9110718 Publication Model: Print Cited Medium: Internet ISSN: 1460-2199 (Electronic) Linking ISSN: 10473211 NLM ISO Abbreviation: Cereb Cortex Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Oxford University Press, c1991- |
| مواضيع طبية MeSH: | Parkinson Disease*/physiopathology , Parkinson Disease*/diagnostic imaging , Parkinson Disease*/complications , Autonomic Nervous System Diseases*/physiopathology , Autonomic Nervous System Diseases*/etiology , Electroencephalography*, Humans ; Female ; Male ; Middle Aged ; Aged ; Insular Cortex/diagnostic imaging ; Insular Cortex/physiopathology ; Limbic System/physiopathology ; Limbic System/diagnostic imaging ; Neural Pathways/physiopathology ; Neural Pathways/diagnostic imaging |
| مستخلص: | Autonomic symptoms in Parkinson's disease result from variable involvement of the central and peripheral systems, but many aspects remain unclear. The analysis of functional connectivity has shown promising results in assessing the pathophysiology of Parkinson's disease. This study aims to investigate the association between autonomic symptoms and cortical functional connectivity in early Parkinson's disease patients using high-density EEG. 53 early Parkinson's disease patients (F/M 18/35) and 49 controls (F/M 20/29) were included. Autonomic symptoms were evaluated using the Scales for Outcomes in Parkinson's disease-Autonomic Dysfunction score. Data were recorded with a 64-channel EEG system. We analyzed cortical functional connectivity, based on weighted phase-lag index, in θ-α-β-low-γ bands. A network-based statistic was used to perform linear regression between Scales for Outcomes in Parkinson's disease-Autonomic Dysfunction score and functional connectivity in Parkinson's disease patients. We observed a positive relation between the Scales for Outcomes in Parkinson's disease-Autonomic Dysfunction score and α-functional connectivity (network τ = 2.8, P = 0.038). Regions with higher degrees were insula and limbic lobe. Moreover, we found positive correlations between the mean connectivity of this network and the gastrointestinal, cardiovascular, and thermoregulatory domains of Scales for Outcomes in Parkinson's disease-Autonomic Dysfunction. Our results revealed abnormal functional connectivity in specific areas in Parkinson's disease patients with greater autonomic symptoms. Insula and limbic areas play a significant role in the regulation of the autonomic system. Increased functional connectivity in these regions might represent the central compensatory mechanism of peripheral autonomic dysfunction in Parkinson's disease. (© The Author(s) 2024. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.) |
| معلومات مُعتمدة: | NEXTGENERATIONEU; Ministry of University and Research; National Recovery and Resilience Plan; PE0000006 MNESYS; DN. 1553 11.10.2022 A Multiscale Integratedapproach to the Study of the Nervous System in Health and Disease |
| فهرسة مساهمة: | Keywords: EEG; Parkinson’s disease; autonomic symptoms; central autonomic network; functional connectivity |
| تواريخ الأحداث: | Date Created: 20240705 Date Completed: 20240705 Latest Revision: 20240705 |
| رمز التحديث: | 20240705 |
| DOI: | 10.1093/cercor/bhae270 |
| PMID: | 38967041 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1460-2199 |
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| DOI: | 10.1093/cercor/bhae270 |