دورية أكاديمية
أعرض في EDS

"Rigid-Flexible" Dual-Ferrocene Chimeric Nanonetwork for Simultaneous Tumor-Targeted Tracing and Photothermal/Photodynamic Therapy.

التفاصيل البيبلوغرافية
العنوان: "Rigid-Flexible" Dual-Ferrocene Chimeric Nanonetwork for Simultaneous Tumor-Targeted Tracing and Photothermal/Photodynamic Therapy.
المؤلفون: Wang S; School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, P. R. China., Zhang R; School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, P. R. China., Li X; School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, P. R. China., Chen Y; School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, P. R. China., Zhu L; School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, P. R. China., Yang B; School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, P. R. China., Wang J; School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, P. R. China., Du YH; School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, P. R. China., Liu J; Wuya College of Innovation, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, P. R. China., Ye TT; School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, P. R. China., Wang S; School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, P. R. China.
المصدر: ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2024 Jul 17; Vol. 16 (28), pp. 36142-36156. Date of Electronic Publication: 2024 Jul 05.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101504991 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1944-8252 (Electronic) Linking ISSN: 19448244 NLM ISO Abbreviation: ACS Appl Mater Interfaces Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, D.C. : American Chemical Society
مواضيع طبية MeSH: Ferrous Compounds*/chemistry , Photochemotherapy* , Metallocenes*/chemistry , Indocyanine Green*/chemistry , Indocyanine Green*/therapeutic use , Indocyanine Green*/pharmacology , Hyaluronic Acid*/chemistry, Humans ; Animals ; Mice ; Photothermal Therapy ; Female ; Fluorescent Dyes/chemistry ; Fluorescent Dyes/pharmacology ; Mice, Inbred BALB C ; Photosensitizing Agents/chemistry ; Photosensitizing Agents/pharmacology ; Photosensitizing Agents/therapeutic use ; Mice, Nude ; Cell Line, Tumor ; Neoplasms/diagnostic imaging ; Neoplasms/drug therapy ; Neoplasms/therapy ; Neoplasms/pathology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Nanoparticles/chemistry ; Nanoparticles/therapeutic use
مستخلص: There is an urgent need to develop phototherapeutic agents with imaging capabilities to assess the treatment process and efficacy in real-time during cancer phototherapy for precision cancer therapy. The safe near-infrared (NIR) fluorescent dyes have garnered significant attention and are desirable for theranostics agents. However, until now, achieving excellent photostability and fluorescence (FL) imaging capability in aggregation-caused quenching (ACQ) dyes remains a big challenge. Here, for the only FDA-approved NIR dye, indocyanine green (ICG), we developed a dual-ferrocene (Fc) chimeric nanonetwork ICG@HFFC based on the rigid-flexible strategy through one-step self-assembly, which uses rigid Fc-modified hyaluronic acid (HA) copolymer (HA-Fc) and flexible octadecylamine (ODA) bonded Fc (Fc-C 18 ) as the delivery system. HA-Fc reserved the ability of HA to target the CD44 receptor of the tumor cell surface, and the dual-Fc region provided a rigid space for securely binding ICG through metal-ligand interaction and π-π conjugation, ensuring excellent photostability. Additionally, the alkyl chain provided flexible confinement for the remaining ICG through hydrophobic forces, preserving its FL. Thereby, a balance is achieved between outstanding photostability and FL imaging capability. In vitro studies showed improved photobleaching resistance, enhanced FL stability, and increased singlet oxygen ( 1 O 2 ) production efficiency in ICG@HFFC. Further in vivo results display that ICG@HFFC had good tumor tracing ability and significant tumor inhibition which also exhibited good biocompatibility.. Therefore, ICG@HFFC provides an encouraging strategy to realize simultaneous enhanced tumor tracing and photothermal/photodynamic therapy (PTT/PDT) and offers a novel approach to address the limitations of ACQ dyes.
فهرسة مساهمة: Keywords: aggregation-caused quenching (ACQ); ferrocene (Fc); indocyanine green (ICG); rigid-flexible; tumor visualization therapy
المشرفين على المادة: 0 (Ferrous Compounds)
0 (Metallocenes)
U96PKG90JQ (ferrocene)
IX6J1063HV (Indocyanine Green)
9004-61-9 (Hyaluronic Acid)
0 (Fluorescent Dyes)
0 (Photosensitizing Agents)
0 (Antineoplastic Agents)
تواريخ الأحداث: Date Created: 20240705 Date Completed: 20240718 Latest Revision: 20240718
رمز التحديث: 20240718
DOI: 10.1021/acsami.4c06437
PMID: 38968001
قاعدة البيانات: MEDLINE
الوصف
تدمد:1944-8252
DOI:10.1021/acsami.4c06437