دورية أكاديمية
أعرض في EDS

Phenome-wide association study identifies new clinical phenotypes associated with Staphylococcus aureus infections.

التفاصيل البيبلوغرافية
العنوان: Phenome-wide association study identifies new clinical phenotypes associated with Staphylococcus aureus infections.
المؤلفون: Allaire P; Center for Precision Medicine Research, Marshfield Clinic Research Institute, Marshfield, Wisconsin, United States of America., Elsayed NS; Center for Precision Medicine Research, Marshfield Clinic Research Institute, Marshfield, Wisconsin, United States of America., Berg RL; Research Computing and Analytics, Marshfield Clinic Research Institute, Marshfield, Wisconsin, United States of America., Rose W; School of Pharmacy, University of Wisconsin, Madison, Wisconsin, United States of America., Shukla SK; Center for Precision Medicine Research, Marshfield Clinic Research Institute, Marshfield, Wisconsin, United States of America.; Computational and Informatics in Biology and Medicine Program, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
المصدر: PloS one [PLoS One] 2024 Jul 05; Vol. 19 (7), pp. e0303395. Date of Electronic Publication: 2024 Jul 05 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Staphylococcal Infections*/microbiology , Staphylococcal Infections*/genetics , Phenotype* , Staphylococcus aureus*/genetics, Humans ; Male ; Female ; Middle Aged ; Adult ; Aged ; Phenomics ; Genome-Wide Association Study ; Adolescent ; Risk Factors ; Young Adult ; Child
مستخلص: Background: Phenome-Wide Association study (PheWAS) is a powerful tool designed to systematically screen clinical observations derived from medical records (phenotypes) for association with a variable of interest. Despite their usefulness, no systematic screening of phenotypes associated with Staphylococcus aureus infections (SAIs) has been done leaving potential novel risk factors or complications undiscovered.
Method and Cohorts: We tailored the PheWAS approach into a two-stage screening procedure to identify novel phenotypes correlating with SAIs. The first stage screened for co-occurrence of SAIs with other phenotypes within medical records. In the second stage, significant findings were examined for the correlations between their age of onset with that of SAIs. The PheWAS was implemented using the medical records of 754,401 patients from the Marshfield Clinic Health System. Any novel associations discovered were subsequently validated using datasets from TriNetX and All of Us, encompassing 109,884,571 and 118,538 patients respectively.
Results: Forty-one phenotypes met the significance criteria of a p-value < 3.64e-5 and odds ratios of > 5. Out of these, we classified 23 associations either as risk factors or as complications of SAIs. Three novel associations were discovered and classified either as a risk (long-term use of aspirin) or complications (iron deficiency anemia and anemia of chronic disease). All novel associations were replicated in the TriNetX cohort. In the All of Us cohort, anemia of chronic disease was replicated according to our significance criteria.
Conclusions: The PheWAS of SAIs expands our understanding of SAIs interacting phenotypes. Additionally, the novel two-stage PheWAS approach developed in this study can be applied to examine other disease-disease interactions of interest. Due to the possibility of bias inherent in observational data, the findings of this study require further investigation.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Allaire et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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تواريخ الأحداث: Date Created: 20240705 Date Completed: 20240705 Latest Revision: 20240707
رمز التحديث: 20240707
مُعرف محوري في PubMed: PMC11226111
DOI: 10.1371/journal.pone.0303395
PMID: 38968223
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0303395