دورية أكاديمية
Association of germinal matrix hemorrhage volume with neurodevelopment and hydrocephalus.
| العنوان: | Association of germinal matrix hemorrhage volume with neurodevelopment and hydrocephalus. |
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| المؤلفون: | Yang PH; Departments of1Neurological Surgery., Karuparti S; 2University of Missouri School of Medicine, Columbia, Missouri., Varagur K; Departments of1Neurological Surgery., Alexopoulos D; 3Division of Biostatistics, Washington University in St. Louis, Missouri., Reeder RW; 4Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah; and., Lean RE; 5Psychiatry., Rogers CE; 5Psychiatry.; 8Pediatrics, and., Limbrick DD; Departments of1Neurological Surgery.; 6Department of Neurological Surgery, Virginia Commonwealth University, Richmond, Virginia., Smyser CD; 7Neurology.; 8Pediatrics, and.; 9Radiology, Washington University in St. Louis, Missouri., Strahle JM; Departments of1Neurological Surgery. |
| المصدر: | Journal of neurosurgery. Pediatrics [J Neurosurg Pediatr] 2024 Jul 05, pp. 1-10. Date of Electronic Publication: 2024 Jul 05. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association of Neurological Surgeons Country of Publication: United States NLM ID: 101463759 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1933-0715 (Electronic) Linking ISSN: 19330707 NLM ISO Abbreviation: J Neurosurg Pediatr Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Charlottesville, VA : American Association of Neurological Surgeons, 2004- |
| مستخلص: | Objective: The objective of this study was to evaluate whether volumetric measurements on early cranial ultrasound (CUS) in high-grade germinal matrix hemorrhage-intraventricular hemorrhage (GMH-IVH) are associated with hydrocephalus and neurodevelopmental metrics. Methods: A retrospective case series analysis of infants with high-grade GMH-IVH admitted to the St. Louis Children's Hospital neonatal intensive care unit between 2007 and 2015 who underwent neurodevelopmental testing using the Bayley Scales of Infant and Toddler Development, 3rd Edition (Bayley-III) at 2 years of corrected age was performed. GMH volume, periventricular hemorrhagic infarction volume, and frontotemporal horn ratio were obtained from direct review of neonatal CUS studies. Univariate and multivariable regression models were used to evaluate the association between hemorrhage volumes and hydrocephalus requiring permanent CSF diversion with ventricular shunt or endoscopic third ventriculostomy with or without choroid plexus cauterization and composite Bayley-III cognitive, language, and motor scores. Results: Forty-three infants (29 males, mean gestational age 25 weeks) met the inclusion criteria. The mean age at time of the CUS with the largest hemorrhage volume or first diagnosis of highest grade was 6.2 days. Nineteen patients underwent treatment for hydrocephalus with permanent CSF diversion. In multivariable analyses, larger GMH volume was associated with worse estimated Bayley-III cognitive (left-sided GMH volume: p = 0.048, total GMH volume: p = 0.023) and motor (left-sided GMH volume: p = 0.010; total GMH volume: p = 0.014) scores. Larger periventricular hemorrhagic infarction volume was associated with worse estimated Bayley-III motor scores (each side p < 0.04). Larger left-sided (OR 2.55, 95% CI 1.10-5.88; p = 0.028) and total (OR 1.35, 95% CI 1.01-1.79; p = 0.041) GMH volumes correlated with hydrocephalus. There was no relationship between early ventricular volume and hydrocephalus or neurodevelopmental outcomes. Conclusions: Location-specific hemorrhage volume on early CUS may be prognostic for neurodevelopmental and hydrocephalus outcomes in high-grade GMH-IVH. |
| فهرسة مساهمة: | Keywords: germinal matrix hemorrhage; hydrocephalus; neonatal; neurodevelopment; ultrasound |
| تواريخ الأحداث: | Date Created: 20240705 Latest Revision: 20240705 |
| رمز التحديث: | 20240706 |
| DOI: | 10.3171/2024.3.PEDS22376 |
| PMID: | 38968622 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1933-0715 |
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| DOI: | 10.3171/2024.3.PEDS22376 |