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O-GlcNAc signaling: Implications for stress-induced adaptive response pathway in the tumor microenvironment.

التفاصيل البيبلوغرافية
العنوان: O-GlcNAc signaling: Implications for stress-induced adaptive response pathway in the tumor microenvironment.
المؤلفون: Zhao Y; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Sciences, Northwest University, Xi'an, 710069, China., Li R; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, 710032, China., Wang W; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, 710032, China., Zhang H; Department of Digestive Surgery, Honghui Hospital, Xi'an Jiaotong University, 710054, Xi'an, Shaanxi, China., Zhang Q; Second Clinical Medicine College, Shaanxi University of Chinese Medicine, Xianyang, 712046, China., Jiang J; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, 710032, China., Wang Y; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Sciences, Northwest University, Xi'an, 710069, China., Li Y; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, 710032, China., Guan F; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Sciences, Northwest University, Xi'an, 710069, China. Electronic address: guanfeng@nwu.edu.cn., Nie Y; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Sciences, Northwest University, Xi'an, 710069, China; State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, 710032, China. Electronic address: yongznie@fmmu.edu.cn.
المصدر: Cancer letters [Cancer Lett] 2024 Aug 28; Vol. 598, pp. 217101. Date of Electronic Publication: 2024 Jul 04.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 7600053 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7980 (Electronic) Linking ISSN: 03043835 NLM ISO Abbreviation: Cancer Lett Subsets: MEDLINE
أسماء مطبوعة: Publication: Limerick : Elsevier Science Ireland
Original Publication: Amsterdam, Elsevier/North-Holland.
مواضيع طبية MeSH: Tumor Microenvironment* , Signal Transduction* , Neoplasms*/metabolism , Neoplasms*/pathology , Neoplasms*/genetics , Acetylglucosamine*/metabolism, Humans ; N-Acetylglucosaminyltransferases/metabolism ; N-Acetylglucosaminyltransferases/genetics ; Animals ; Oxidative Stress ; Stress, Physiological ; Glycosylation
مستخلص: The tumor microenvironment (TME) consists of tumor cells, non-tumor cells, extracellular matrix, and signaling molecules, which can contribute to tumor initiation, progression, and therapy resistance. In response to starvation, hypoxia, and drug treatments, tumor cells undergo a variety of deleterious endogenous stresses, such as hypoxia, DNA damage, and oxidative stress. In this context, to survive the difficult situation, tumor cells evolve multiple conserved adaptive responses, including metabolic reprogramming, DNA damage checkpoints, homologous recombination, up-regulated antioxidant pathways, and activated unfolded protein responses. In the last decades, the protein O-GlcNAcylation has emerged as a crucial causative link between glucose metabolism and tumor progression. Here, we discuss the relevant pathways that regulate the above responses. These pathways are adaptive adjustments induced by endogenous stresses in cells. In addition, we systematically discuss the role of O-GlcNAcylation-regulated stress-induced adaptive response pathways (SARPs) in TME remodeling, tumor progression, and treatment resistance. We also emphasize targeting O-GlcNAcylation through compounds that modulate OGT or OGA activity to inhibit tumor progression. It seems that targeting O-GlcNAcylated proteins to intervene in TME may be a novel approach to improve tumor prognosis.
Competing Interests: Declaration of competing interest The authors have declared that no competing interest exists.
(Copyright © 2024. Published by Elsevier B.V.)
فهرسة مساهمة: Keywords: DNA replication and damage stress; Endoplasmic reticulum stress; Hypoxia; Immune activation; Metabolic stress; O-GlcNAcylation; Oxidative stress; Stress-induced adaptive response pathways (SARPs); Tumor microenvironment
المشرفين على المادة: V956696549 (Acetylglucosamine)
EC 2.4.1.- (N-Acetylglucosaminyltransferases)
تواريخ الأحداث: Date Created: 20240705 Date Completed: 20240815 Latest Revision: 20240925
رمز التحديث: 20240925
DOI: 10.1016/j.canlet.2024.217101
PMID: 38969156
قاعدة البيانات: MEDLINE
الوصف
تدمد:1872-7980
DOI:10.1016/j.canlet.2024.217101