دورية أكاديمية
Interplay of RNA-binding proteins controls germ cell development in zebrafish.
| العنوان: | Interplay of RNA-binding proteins controls germ cell development in zebrafish. |
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| المؤلفون: | Shi DL; Laboratory of Developmental Biology, CNRS-UMR7622, Institut de Biologie Paris-Seine (IBPS), Sorbonne University, 75005 Paris, France. Electronic address: de-li.shi@upmc.fr. |
| المصدر: | Journal of genetics and genomics = Yi chuan xue bao [J Genet Genomics] 2024 Sep; Vol. 51 (9), pp. 889-899. Date of Electronic Publication: 2024 Jul 04. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Science press Country of Publication: China NLM ID: 101304616 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1673-8527 (Print) Linking ISSN: 16738527 NLM ISO Abbreviation: J Genet Genomics Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Beijing : Orlando, FL : Science press ; Elsevier |
| مواضيع طبية MeSH: | Zebrafish*/genetics , Zebrafish*/metabolism , RNA-Binding Proteins*/metabolism , RNA-Binding Proteins*/genetics , Germ Cells*/metabolism , Germ Cells*/growth & development, Animals ; Zebrafish Proteins/genetics ; Zebrafish Proteins/metabolism ; Gene Expression Regulation, Developmental ; Cell Differentiation/genetics |
| مستخلص: | The specification of germ cells in zebrafish mostly relies on an inherited mechanism by which localized maternal determinants, called germ plasm, confer germline fate in the early embryo. Extensive studies have partially allowed the identification of key regulators governing germ plasm formation and subsequent germ cell development. RNA-binding proteins, acting in concert with other germ plasm components, play essential roles in the organization of the germ plasm and the specification, migration, maintenance, and differentiation of primordial germ cells. The loss of their functions impairs germ cell formation and causes sterility or sexual conversion. Evidence is emerging that they instruct germline development through differential regulation of mRNA fates in somatic and germ cells. However, the challenge remains to decipher the complex interplay of maternal germ plasm components in germ plasm compartmentalization and germ cell specification. Because failure to control the developmental outcome of germ cells disrupts the formation of gametes, it is important to gain a complete picture of regulatory mechanisms operating in the germ cell lineage. This review sheds light on the contributions of RNA-binding proteins to germ cell development in zebrafish and highlights intriguing questions that remain open for future investigation. Competing Interests: Conflict of interest The author declares no competing interests. (Copyright © 2024 Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Gametogenesis; Germ plasm; Germline stem cell; Posttranscriptional gene expression; Primordial germ cell; RNA-binding protein; Translational activation and repression; Zebrafish |
| المشرفين على المادة: | 0 (RNA-Binding Proteins) 0 (Zebrafish Proteins) |
| تواريخ الأحداث: | Date Created: 20240705 Date Completed: 20240905 Latest Revision: 20240905 |
| رمز التحديث: | 20240906 |
| DOI: | 10.1016/j.jgg.2024.06.020 |
| PMID: | 38969260 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1673-8527 |
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| DOI: | 10.1016/j.jgg.2024.06.020 |