دورية أكاديمية
Towards targeting the breast cancer immune microenvironment.
| العنوان: | Towards targeting the breast cancer immune microenvironment. |
|---|---|
| المؤلفون: | Harris MA; The Sir Peter MacCallum Department of Medical Oncology, University of Melbourne, Melbourne, Victoria, Australia.; Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Savas P; The Sir Peter MacCallum Department of Medical Oncology, University of Melbourne, Melbourne, Victoria, Australia.; Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Virassamy B; The Sir Peter MacCallum Department of Medical Oncology, University of Melbourne, Melbourne, Victoria, Australia.; Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., O'Malley MMR; The Sir Peter MacCallum Department of Medical Oncology, University of Melbourne, Melbourne, Victoria, Australia.; Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Kay J; The Sir Peter MacCallum Department of Medical Oncology, University of Melbourne, Melbourne, Victoria, Australia.; Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Mueller SN; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, Victoria, Australia., Mackay LK; Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, Victoria, Australia., Salgado R; Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.; Department of Pathology, ZAS Ziekenhuizen, Antwerp, Belgium., Loi S; The Sir Peter MacCallum Department of Medical Oncology, University of Melbourne, Melbourne, Victoria, Australia. sherene.loi@petermac.org.; Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. sherene.loi@petermac.org. |
| المصدر: | Nature reviews. Cancer [Nat Rev Cancer] 2024 Jul 05. Date of Electronic Publication: 2024 Jul 05. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101124168 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-1768 (Electronic) Linking ISSN: 1474175X NLM ISO Abbreviation: Nat Rev Cancer Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London, UK : Nature Pub. Group, [c2001- |
| مستخلص: | The tumour immune microenvironment is shaped by the crosstalk between cancer cells, immune cells, fibroblasts, endothelial cells and other stromal components. Although the immune tumour microenvironment (TME) serves as a source of therapeutic targets, it is also considered a friend or foe to tumour-directed therapies. This is readily illustrated by the importance of T cells in triple-negative breast cancer (TNBC), culminating in the advent of immune checkpoint therapy in combination with cytotoxic chemotherapy as standard of care for both early and advanced-stage TNBC, as well as recent promising signs of efficacy in a subset of hormone receptor-positive disease. In this Review, we discuss the various components of the immune TME in breast cancer and therapies that target or impact the immune TME, as well as the complexity of host physiology. (© 2024. Springer Nature Limited.) |
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