دورية أكاديمية
أعرض في EDS

Rose Bengal diacetate-mediated antimicrobial photodynamic inactivation: potentiation by potassium iodide and acceleration of wound healing in MRSA-infected diabetic mice.

التفاصيل البيبلوغرافية
العنوان: Rose Bengal diacetate-mediated antimicrobial photodynamic inactivation: potentiation by potassium iodide and acceleration of wound healing in MRSA-infected diabetic mice.
المؤلفون: Wei D; Department of Dermatology, West China Hospital, Sichuan University, No.37 Guo Xue Alley, Chengdu, 610041, China.; Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-related Molecular Network West China Hospital, Sichuan University, Chengdu, 610041, China., Hamblin MR; Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, 2028, South Africa., Wang H; Department of Dermatology, West China Hospital, Sichuan University, No.37 Guo Xue Alley, Chengdu, 610041, China.; Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-related Molecular Network West China Hospital, Sichuan University, Chengdu, 610041, China., Fekrazad R; Radiation Sciences Research Center, Laser Research Center in Medical Sciences, AJA University of Medical Sciences, Tehran, Iran.; International Network for Photo Medicine and Photo Dynamic Therapy (INPMPDT), Universal Scientific Education and Research Network (USERN), Tehran, Iran., Wang C; Department of Endocrinology and Metabolism, Center for Diabetes and Metabolism Research, West China Hospital, Sichuan University, Chengdu, 610041, China., Wen X; Department of Dermatology, West China Hospital, Sichuan University, No.37 Guo Xue Alley, Chengdu, 610041, China. xiangwen_wcums@163.com.; Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-related Molecular Network West China Hospital, Sichuan University, Chengdu, 610041, China. xiangwen_wcums@163.com.
المصدر: BMC microbiology [BMC Microbiol] 2024 Jul 05; Vol. 24 (1), pp. 246. Date of Electronic Publication: 2024 Jul 05.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100966981 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2180 (Electronic) Linking ISSN: 14712180 NLM ISO Abbreviation: BMC Microbiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-
مواضيع طبية MeSH: Rose Bengal*/pharmacology , Methicillin-Resistant Staphylococcus aureus*/drug effects , Wound Healing*/drug effects , Potassium Iodide*/pharmacology , Candida albicans*/drug effects , Photosensitizing Agents*/pharmacology , Staphylococcal Infections*/drug therapy , Staphylococcal Infections*/microbiology, Animals ; Mice ; Escherichia coli/drug effects ; Diabetes Mellitus, Experimental/microbiology ; Diabetes Mellitus, Experimental/drug therapy ; Photochemotherapy/methods ; Drug Synergism ; Light ; Male
مستخلص: Previous studies have shown that antimicrobial photodynamic inactivation (aPDI) can be strongly potentiated by the addition of the non-toxic inorganic salt, potassium iodide (KI). This approach was shown to apply to many different photosensitizers, including the xanthene dye Rose Bengal (RB) excited by green light (540 nm). Rose Bengal diacetate (RBDA) is a lipophilic RB derivative that is easily taken up by cells and hydrolyzed to produce an active photosensitizer. Because KI is not taken up by microbial cells, it was of interest to see if aPDI mediated by RBDA could also be potentiated by KI. The addition of 100 mM KI strongly potentiated the killing of Gram-positive methicillin-resistant Staphylocccus aureus, Gram-negative Eschericia coli, and fungal yeast Candida albicans when treated with RBDA (up to 15 µM) for 2 hours followed by green light (540 nm, 10 J/cm 2 ). Both RBDA aPDI regimens (400 µM RBDA with or without 400 mM KI followed by 20 J/cm 2 green light) accelerated the healing of MRSA-infected excisional wounds in diabetic mice, without damaging the host tissue.
(© 2024. The Author(s).)
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معلومات مُعتمدة: 2022NSFSC1414 the Science and Technology Department of Sichuan Province; 81903226 National Natural Science Foundation of China
فهرسة مساهمة: Keywords: Antimicrobial photodynamic inactivation; Diabetic mouse infected wound; Methicillin-resistant staphylococcus aureus; Potassium iodide potentiation; Rose bengal diacetate
المشرفين على المادة: 1ZPG1ELY14 (Rose Bengal)
1C4QK22F9J (Potassium Iodide)
0 (Photosensitizing Agents)
تواريخ الأحداث: Date Created: 20240705 Date Completed: 20240705 Latest Revision: 20240708
رمز التحديث: 20240708
مُعرف محوري في PubMed: PMC11225387
DOI: 10.1186/s12866-024-03401-6
PMID: 38970013
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-2180
DOI:10.1186/s12866-024-03401-6