دورية أكاديمية
Predictive accuracy of genetic variants for eye color in a Kazakh population using the IrisPlex system.
العنوان: | Predictive accuracy of genetic variants for eye color in a Kazakh population using the IrisPlex system. |
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المؤلفون: | Bukayev A; National Center for Biotechnology, Astana, 010000, Kazakhstan., Gorin I; Research Centre for Medical Genetics, Moscow, 115522, Russia., Aidarov B; National Center for Biotechnology, Astana, 010000, Kazakhstan., Darmenov A; Karaganda Academy of the Ministry of Internal Affairs of the Republic of Kazakhstan named after Barimbek Beisenov, Karaganda, 100000, Kazakhstan., Balanovska E; Research Centre for Medical Genetics, Moscow, 115522, Russia., Zhabagin M; National Center for Biotechnology, Astana, 010000, Kazakhstan. zhabagin@biocenter.kz. |
المصدر: | BMC research notes [BMC Res Notes] 2024 Jul 05; Vol. 17 (1), pp. 187. Date of Electronic Publication: 2024 Jul 05. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Biomed Central Country of Publication: England NLM ID: 101462768 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-0500 (Electronic) Linking ISSN: 17560500 NLM ISO Abbreviation: BMC Res Notes Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: London : Biomed Central, 2008. |
مواضيع طبية MeSH: | Eye Color*/genetics, Humans ; Kazakhstan ; Genetic Variation/genetics ; Phenotype ; Genotype ; Genetics, Population/methods ; Asian People/genetics |
مستخلص: | Objective: This study assesses the accuracy of the IrisPlex system, a genetic eye color prediction tool for forensic analysis, in the Kazakh population. The study compares previously published genotypes of 515 Kazakh individuals from varied geographical and ethnohistorical contexts with phenotypic data on their eye color, introduced for the first time in this research. Results: The IrisPlex panel's effectiveness in predicting eye color in the Kazakh population was validated. It exhibited slightly lower accuracy than in Western European populations but was higher than in Siberian populations. The sensitivity was notably high for brown-eyed individuals (0.99), but further research is needed for blue and intermediate eye colors. This study establishes IrisPlex as a useful predictive tool in the Kazakh population and provides a basis for future investigations into the genetic basis of phenotypic variations in this diverse population. (© 2024. The Author(s).) |
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معلومات مُعتمدة: | AP09058276 Science Committee of the Ministry of Science and Higer Education of the Republic of Kazakhstan; AP09058276 Science Committee of the Ministry of Science and Higer Education of the Republic of Kazakhstan; AP09058276 Science Committee of the Ministry of Science and Higer Education of the Republic of Kazakhstan; AP09058276 Science Committee of the Ministry of Science and Higer Education of the Republic of Kazakhstan |
فهرسة مساهمة: | Keywords: Eye color; Forensic genetics, IrisPlex System; Kazakh population; Microarray; SNP Genotyping |
تواريخ الأحداث: | Date Created: 20240705 Date Completed: 20240706 Latest Revision: 20240708 |
رمز التحديث: | 20240708 |
مُعرف محوري في PubMed: | PMC11227171 |
DOI: | 10.1186/s13104-024-06856-y |
PMID: | 38970104 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1756-0500 |
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DOI: | 10.1186/s13104-024-06856-y |