دورية أكاديمية
أعرض في EDS

The role of surgery for invasive pulmonary aspergillosis in paediatric hemato-oncology patients-Can we better define it?

التفاصيل البيبلوغرافية
العنوان: The role of surgery for invasive pulmonary aspergillosis in paediatric hemato-oncology patients-Can we better define it?
المؤلفون: Hassan M; Department of Thoracic Surgery, Medical Center-University of Freiburg, Freiburg im Breisgau, Germany.; Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany., Andresen F; Department of Pediatric Hematology and Oncology, Medical Center-University of Freiburg Faculty of Medicine, University of Freiburg, Freiburg, Germany., Le UT; Department of Thoracic Surgery, Medical Center-University of Freiburg, Freiburg im Breisgau, Germany.; Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany., Passlick B; Department of Thoracic Surgery, Medical Center-University of Freiburg, Freiburg im Breisgau, Germany.; Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany., Schmid S; Department of Thoracic Surgery, Medical Center-University of Freiburg, Freiburg im Breisgau, Germany.; Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany., Puzik A; Department of Pediatric Hematology and Oncology, Medical Center-University of Freiburg Faculty of Medicine, University of Freiburg, Freiburg, Germany.
المصدر: Mycoses [Mycoses] 2024 Jul; Vol. 67 (7), pp. e13763.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Grosse Verlag Country of Publication: Germany NLM ID: 8805008 Publication Model: Print Cited Medium: Internet ISSN: 1439-0507 (Electronic) Linking ISSN: 09337407 NLM ISO Abbreviation: Mycoses Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin : Grosse Verlag, [1988?-
مواضيع طبية MeSH: Invasive Pulmonary Aspergillosis*/mortality , Invasive Pulmonary Aspergillosis*/surgery, Humans ; Child ; Retrospective Studies ; Adolescent ; Male ; Female ; Child, Preschool ; Infant ; Young Adult ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hematologic Neoplasms/complications ; Treatment Outcome
مستخلص: Background: Invasive pulmonary aspergillosis (IPA) is a serious condition with high morbidity and mortality in paediatric patients with cancer, haematological diseases or immunodeficiencies with or without allogeneic haematopoietic stem cell transplantation (HSCT). The role of surgical intervention for the management of IPA has scarcely been investigated.
Objectives: The aim of this study was to present a single center experience of management of IPA in paediatric patients of an oncological ward, to determine the short and long-term outcomes after thoracic surgical interventions, and to outline the indications of surgical interventions in selected patients.
Patients/methods: We conducted a retrospective study of 44 paediatric patients with proven and probable IPA treated in our institution between January 2003 and December 2021. The primary endpoint was the overall survival after surgical interventions. Secondary endpoints included post-operative morbidity and mortality.
Results: The median age at diagnosis of IPA in our cohort was 11.79 years (range 0.11-19.6). The underlying conditions were malignancies in 34 (77%) patients and haematological or immunological disorders with allogeneic HSCT in 9 (23%) patients. We performed thoracic surgical interventions in 10 (22.7%) patients. Most patients received a video assisted thoracic surgery. Only one patient died within 90 days after surgery with a median follow-up time of 50 months. No other major post-operative complications occurred. The calculated 5-year survival rate from IPA for patients after surgical intervention with curative intention was 57% and 56% for patients without (p = .8216).
Conclusions: IPA resulted in relevant morbidity and mortality in our paediatric patient cohort. Thoracic surgical interventions are feasible and may be associated with prolonged survival as a part of multidisciplinary approach in selected paediatric patients with IPA. Larger scale studies are necessary to investigate the variables associated with the necessity of surgery.
(© 2024 The Author(s). Mycoses published by Wiley‐VCH GmbH.)
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فهرسة مساهمة: Keywords: VATS; invasive pulmonary aspergillosis; lung surgery; paediatric patients
تواريخ الأحداث: Date Created: 20240706 Date Completed: 20240706 Latest Revision: 20240706
رمز التحديث: 20240707
DOI: 10.1111/myc.13763
PMID: 38970218
قاعدة البيانات: MEDLINE
الوصف
تدمد:1439-0507
DOI:10.1111/myc.13763