دورية أكاديمية
Aberrant type 2 dopamine receptor availability in violent offenders with psychopathy.
| العنوان: | Aberrant type 2 dopamine receptor availability in violent offenders with psychopathy. |
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| المؤلفون: | Lukkarinen L; Turku PET Centre, University of Turku, Finland; Psychiatric Hospital for Prisoners, University of Turku, Finland., Tuisku J; Turku PET Centre, University of Turku, Finland., Sun L; Turku PET Centre, University of Turku, Finland., Helin S; Turku PET Centre, University of Turku, Finland., Karlsson HK; Turku PET Centre, University of Turku, Finland., Venetjoki N; Psychiatric Hospital for Prisoners, University of Turku, Finland., Salomaa M; Psychiatric Hospital for Prisoners, University of Turku, Finland., Rautio P; Turku Prison Outpatient Clinic, University of Turku, Finland., Hirvonen J; Turku PET Centre, University of Turku, Finland., Lauerma H; Psychiatric Hospital for Prisoners, University of Turku, Finland., Tiihonen J; Department of Clinical Neuroscience, Karolinska Institutet and Center for Psychiatry Research, Stockholm City Council, Stockholm, Sweden; Department of Forensic Psychiatry, University of Eastern Finland, Niuvanniemi Hospital, Kuopio, Finland., Nummenmaa L; Turku PET Centre, University of Turku, Finland; Department of Psychology, University of Turku, Finland; Turku University Hospital, University of Turku, Finland. Electronic address: latanu@utu.fi. |
| المصدر: | NeuroImage [Neuroimage] 2024 Aug 15; Vol. 297, pp. 120724. Date of Electronic Publication: 2024 Jul 04. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academic Press Country of Publication: United States NLM ID: 9215515 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9572 (Electronic) Linking ISSN: 10538119 NLM ISO Abbreviation: Neuroimage Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Orlando, FL : Academic Press, c1992- |
| مواضيع طبية MeSH: | Receptors, Dopamine D2*/metabolism , Antisocial Personality Disorder*/diagnostic imaging , Antisocial Personality Disorder*/metabolism , Positron-Emission Tomography*/methods , Criminals* , Violence*, Humans ; Male ; Adult ; Receptors, Opioid, mu/metabolism ; Raclopride/pharmacokinetics ; Young Adult ; Brain/metabolism ; Brain/diagnostic imaging ; Fentanyl/analogs & derivatives |
| مستخلص: | Psychopathy is characterized by antisocial behavior, poor behavioral control and lacking empathy, and structural alterations in the corresponding neural circuits. Molecular brain basis of psychopathy remains poorly characterized. Here we studied type 2 dopamine receptor (D2R) and mu-opioid receptor (MOR) availability in convicted violent offenders with high psychopathic traits (n = 11) and healthy matched controls (n = 17) using positron emission tomography (PET). D2R were measured with radioligand [ 11 C]raclopride and MORs with radioligand [ 11 C]carfentanil. Psychopathic subjects had lowered D2R availability in caudate and putamen, and striatal D2R availability was also associated with degree of psychopathic traits in this prisoner sample. No group differences were found in MOR availability, although in the prisoner sample, psychopathic traits were negatively correlated with MOR availability in the amygdala and nucleus accumbens. We conclude that D2R signaling could be the putative neuromolecular pathway for psychopathy, whereas evidence for alterations in the MOR system is more limited. Competing Interests: Declaration of competing interest The authors disclose no conflict of interest (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Dopamine; Opioid; Positron emission tomography; Psychopathy; Violence |
| المشرفين على المادة: | 0 (Receptors, Dopamine D2) 0 (Receptors, Opioid, mu) 430K3SOZ7G (Raclopride) LA9DTA2L8F (carfentanil) 0 (DRD2 protein, human) UF599785JZ (Fentanyl) |
| تواريخ الأحداث: | Date Created: 20240706 Date Completed: 20240812 Latest Revision: 20240812 |
| رمز التحديث: | 20240813 |
| DOI: | 10.1016/j.neuroimage.2024.120724 |
| PMID: | 38971486 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1095-9572 |
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| DOI: | 10.1016/j.neuroimage.2024.120724 |