دورية أكاديمية
Acupuncture modulation of the ACE/Ang II/AT1R and ACE2/Ang(1-7)/MasR pathways in the rostral ventrolateral medulla reduces sympathetic output and prevents cardiac injury caused by SHR hypertension.
| العنوان: | Acupuncture modulation of the ACE/Ang II/AT1R and ACE2/Ang(1-7)/MasR pathways in the rostral ventrolateral medulla reduces sympathetic output and prevents cardiac injury caused by SHR hypertension. |
|---|---|
| المؤلفون: | Wu XL; School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing., Zhang L; School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing., Zhang J; School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing., Sun J; School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing., Li YY; School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing., Yang KZ; Department of Rehabilitation Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou., Liu Y; Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China., Gao XY; School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing., Liu QG; School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing. |
| المصدر: | Neuroreport [Neuroreport] 2024 Sep 04; Vol. 35 (13), pp. 839-845. Date of Electronic Publication: 2024 Jun 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 9100935 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-558X (Electronic) Linking ISSN: 09594965 NLM ISO Abbreviation: Neuroreport Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London, England : Lippincott Williams & Wilkins Original Publication: Oxford, UK : Rapid Communications of Oxford Ltd., [1990- |
| مواضيع طبية MeSH: | Rats, Inbred SHR* , Rats, Inbred WKY* , Angiotensin I*/metabolism , Hypertension*/metabolism , Hypertension*/therapy , Peptide Fragments*/metabolism , Angiotensin-Converting Enzyme 2*/metabolism , Receptor, Angiotensin, Type 1*/metabolism , Receptor, Angiotensin, Type 1*/genetics , Medulla Oblongata*/metabolism , Angiotensin II*/metabolism , Acupuncture Therapy*/methods , Peptidyl-Dipeptidase A*/metabolism , Peptidyl-Dipeptidase A*/genetics, Animals ; Male ; Proto-Oncogene Mas ; Sympathetic Nervous System/metabolism ; Rats ; Proto-Oncogene Proteins/metabolism ; Receptors, G-Protein-Coupled/metabolism ; Receptors, G-Protein-Coupled/genetics ; Blood Pressure/physiology ; Signal Transduction/physiology |
| مستخلص: | Acupuncture can reduce blood pressure, heart rate (HR), and ameliorate cardiac damage by modulating the excitability of the sympathetic nervous system, but the exact mechanism of this effect remains unclear. This study investigated the potential mechanisms of acupuncture in the treatment of cardiac damage in hypertension. Spontaneously hypertensive rats (SHR) were used as the hypertension model with Wistar-Kyoto rats as the control. Manual acupuncture, electroacupuncture, and metoprolol were used as interventions. Systolic and diastolic blood pressure (SBP, DBP) plus HR were monitored with cardiac structure determined using Masson staining. Angiotensin II (Ang II) and norepinephrine in myocardium were detected with ELISA as was Ang(1-7) and gamma aminobutyric acid (GABA) in the rostral ventrolateral medulla (RVLM). Expression of mRNA for collagen type I (Col-I), Col-III, actin α1 (ACTA1), and thrombospondin 4 (THBS4) in myocardium was detected using real-time PCR. Expression of angiotensin converting enzyme (ACE), Ang II, angiotensin II type 1 receptor (AT1R), ACE2, and Mas receptor (MasR) proteins in RVLM was monitored using western blot. After manual acupuncture and electroacupuncture treatment, SHRs showed decreased SBP, DBP and HR, reduced myocardial damage. There was decreased expression of the ACE/Ang II/AT1R axis, and increased expression of the ACE2/Ang(1-7)/MasR axis within the RVLM. GABA levels were increased within the RVLM and norepinephrine levels were decreased in myocardial tissue. Metoprolol was more effective than either manual acupuncture or electroacupuncture. Acupuncture directed against hypertensive cardiac damage may be associated with regulation of ACE/Ang II/AT1R and the ACE2/Ang(1-7)/MasR pathway within the RLVM to reduce cardiac sympathetic excitability. (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.) |
| References: | National Health and Family Planning Commission Expert Committee on Rational Use of Medicines Chinese Medical Doctors Association Hypertension Specialized Committee. Guide to the rational use of drugs for hypertension. 2nd ed. Chinese Journal of Frontiers in Medicine (electronic version) 2017; 9:28–126. Smith PA, Graham LN, Mackintosh AF, Stoker JB, Mary DA. Relationship between central sympathetic activity and stages of human hypertension. Am J Hypertens 2004; 17:217–222. Zhai YJ, Yang H, Chen WL, Liu Y, Wei LP, Liu KQ, et al. Study on the stabilizing antihypertensive and cardioprotective effects of aliskiren on spontaneously hypertensive rats. Tianjin Medicine 2022; 50:481–486. Mirza M, Robinson P, Kremneva E, Copeland O, Nikolaeva O, Watkins H, et al. The effect of mutations in alpha-tropomyosin (E40K and E54K) that cause familial dilated cardiomyopathy on the regulatory mechanism of cardiac muscle thin filaments. J Biol Chem 2007; 282:13487–13497. Adams JC, Lawler J. The thrombospondins. Cold Spring Harb Perspect Biol 2011; 3:a009712. Llorens-Cortes C, Touyz RM. Evolution of a new class of antihypertensive drugs: targeting the brain renin-angiotensin system. Hypertension 2020; 75:6–15. Xue B, Zhang Y, Johnson AK. Interactions of the brain renin-angiotensin-system (RAS) and inflammation in the sensitization of hypertension. Front Neurosci 2020; 14:650. Santos RAS, Sampaio WO, Alzamora AC, Motta-Santos D, Alenina N, Bader M, et al. The ACE2/angiotensin-(1-7)/MAS axis of the renin-angiotensin system: focus on angiotensin-(1-7). Physiol Rev 2018; 98:505–553. Azevedo ER, Mak S, Floras JS, Parker JD. Acute effects of angiotensin-converting enzyme inhibition versus angiotensin II receptor blockade on cardiac sympathetic activity in patients with heart failure. Am J Physiol Regul Integr Comp Physiol 2017; 313:R410–R417. Tan YY, Wang YY, Zhang Q. Electroacupuncture of ‘Quchi’ (LI 11) inhibits the elevation of arterial blood pressure and abnormal sympathetic nerve activity in hypertension rats. Zhen Ci Yan Jiu 2016; 41:144–149. Zhou W, Longhurst JC. Neuroendocrine mechanisms of acupuncture in the treatment of hypertension. Evid Based Complement Alternat Med 2012; 2012:878673. Uchida S, Shimura M, Ohsawa H, Suzuki A. Neural mechanism of bradycardiac responses elicited by acupuncture-like stimulation to a hind limb in anesthetized rats. J Physiol Sci 2007; 57:377–382. Jadhav U, Tiwaskar M, Khan A, Kalmath BC, Ponde CK, Sawhney J, et al. Hypertension in young adults in India: perspectives and therapeutic options amongst clinician’s in a cross sectional observational study. J Assoc Physicians India 2021; 69:11–12. Hu J, Li Y, Cheng W, Yang Z, Wang F, Lv P, et al. Comparison of the efficacy of surgical renal denervation and pharmacologic therapies in post-myocardial infarction heart failure. PLoS One 2014; 9:e96996. González A, Schelbert EB, Díez J, Butler J. Myocardial interstitial fibrosis in heart failure: biological and translational perspectives. J Am Coll Cardiol 2018; 71:1696–1706. Frolova EG, Sopko N, Blech L, Popovic ZB, Li J, Vasanji A, et al. Thrombospondin-4 regulates fibrosis and remodeling of the myocardium in response to pressure overload. FASEB J 2012; 26:2363–2373. Miller AJ, Arnold AC. The renin-angiotensin system in cardiovascular autonomic control: recent developments and clinical implications. Clin Auton Res 2019; 29:231–243. Stern JE, Son S, Biancardi VC, Zheng H, Sharma N, Patel KP. Astrocytes contribute to angiotensin II stimulation of hypothalamic neuronal activity and sympathetic outflow. Hypertension 2016; 68:1483–1493. Chan SH, Chan JY. Brain stem oxidative stress and its associated signaling in the regulation of sympathetic vasomotor tone. J Appl Physiol (1985) 2012; 113:1921–1928. Kishi T, Hirooka Y. Oxidative stress in the brain causes hypertension via sympathoexcitation. Front Physiol 2012; 3:335. Doobay MF, Talman LS, Obr TD, Tian X, Davisson RL, Lazartigues E. Differential expression of neuronal ACE2 in transgenic mice with overexpression of the brain renin-angiotensin system. Am J Physiol Regul Integr Comp Physiol 2007; 292:R373–R381. Xia H, Feng Y, Obr TD, Hickman PJ, Lazartigues E. Angiotensin II type 1 receptor-mediated reduction of angiotensin-converting enzyme 2 activity in the brain impairs baroreflex function in hypertensive mice. Hypertension 2009; 53:210–216. Becker LK, Etelvino GM, Walther T, Santos RA, Campagnole-Santos MJ. Immunofluorescence localization of the receptor Mas in cardiovascular-related areas of the rat brain. Am J Physiol Heart Circ Physiol 2007; 293:H1416–H1424. Xiao X, Zhang C, Ma X, Miao H, Wang J, Liu L, et al. Angiotensin-(1-7) counteracts angiotensin II-induced dysfunction in cerebral endothelial cells via modulating Nox2/ROS and PI3K/NO pathways. Exp Cell Res 2015; 336:58–65. |
| المشرفين على المادة: | IJ3FUK8MOF (angiotensin I (1-7)) 9041-90-1 (Angiotensin I) 0 (Peptide Fragments) EC 3.4.17.23 (Angiotensin-Converting Enzyme 2) 0 (Receptor, Angiotensin, Type 1) 11128-99-7 (Angiotensin II) EC 3.4.15.1 (Peptidyl-Dipeptidase A) EC 3.4.17.23 (Ace2 protein, rat) 0 (Proto-Oncogene Mas) 0 (Proto-Oncogene Proteins) 0 (Receptors, G-Protein-Coupled) |
| تواريخ الأحداث: | Date Created: 20240708 Date Completed: 20240805 Latest Revision: 20240812 |
| رمز التحديث: | 20240813 |
| DOI: | 10.1097/WNR.0000000000002073 |
| PMID: | 38973500 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1473-558X |
|---|---|
| DOI: | 10.1097/WNR.0000000000002073 |