دورية أكاديمية
أعرض في EDS

Stearidonic acid improves eicosapentaenoic acid status: studies in humans and cultured hepatocytes.

التفاصيل البيبلوغرافية
العنوان: Stearidonic acid improves eicosapentaenoic acid status: studies in humans and cultured hepatocytes.
المؤلفون: Seidel U; Institute of Human Nutrition and Food Science, University of Kiel, Kiel, Germany., Eberhardt K; Institute of Food Chemistry, TU Braunschweig, Braunschweig, Germany., Wiebel M; Chair of Food Chemistry, Faculty of Mathematics and Natural Sciences, University of Wuppertal, Wuppertal, Germany., Luersen K; Institute of Human Nutrition and Food Science, University of Kiel, Kiel, Germany., Ipharraguerre IR; Institute of Human Nutrition and Food Science, University of Kiel, Kiel, Germany., Haegele FA; Institute of Human Nutrition and Food Science, University of Kiel, Kiel, Germany., Winterhalter P; Institute of Food Chemistry, TU Braunschweig, Braunschweig, Germany., Bosy-Westphal A; Institute of Human Nutrition and Food Science, University of Kiel, Kiel, Germany., Schebb NH; Chair of Food Chemistry, Faculty of Mathematics and Natural Sciences, University of Wuppertal, Wuppertal, Germany., Rimbach G; Institute of Human Nutrition and Food Science, University of Kiel, Kiel, Germany.
المصدر: Frontiers in nutrition [Front Nutr] 2024 Apr 04; Vol. 11, pp. 1359958. Date of Electronic Publication: 2024 Apr 04 (Print Publication: 2024).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Media S. A Country of Publication: Switzerland NLM ID: 101642264 Publication Model: eCollection Cited Medium: Print ISSN: 2296-861X (Print) Linking ISSN: 2296861X NLM ISO Abbreviation: Front Nutr Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne, Switzerland : Frontiers Media S. A., [2014]-
مستخلص: Background: Ahiflower oil from the seeds of Buglossoides arvensis is rich in α-linolenic acid (ALA) and stearidonic acid (SDA). ALA and SDA are potential precursor fatty acids for the endogenous synthesis of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which are n3-long chain polyunsaturated fatty acids (n3-LC-PUFAS), in humans. Since taurine, an amino sulfonic acid, is often associated with tissues rich in n3-LC-PUFAS (e.g., in fatty fish, human retina), taurine may play a role in EPA- and DHA-metabolism.
Objective: To examine the capacity of the plant-derived precursor fatty acids (ALA and SDA) and of the potential fatty acid metabolism modulator taurine to increase n3-LC-PUFAS and their respective oxylipins in human plasma and cultivated hepatocytes (HepG2 cells).
Methods: In a monocentric, randomized crossover study 29 healthy male volunteers received three sequential interventions, namely ahiflower oil (9 g/day), taurine (1.5 g/day) and ahiflower oil (9 g/day) + taurine (1.5 g/day) for 20 days. In addition, cultivated HepG2 cells were treated with isolated fatty acids ALA, SDA, EPA, DHA as well as taurine alone or together with SDA.
Results: Oral ahiflower oil intake significantly improved plasma EPA levels (0.2 vs. 0.6% of total fatty acid methyl esters (FAMES)) in humans, whereas DHA levels were unaffected by treatments. EPA-levels in SDA-treated HepG2 cells were 65% higher (5.1 vs. 3.0% of total FAMES) than those in ALA-treated cells. Taurine did not affect fatty acid profiles in human plasma in vivo or in HepG2 cells in vitro . SDA-rich ahiflower oil and isolated SDA led to an increase in EPA-derived oxylipins in humans and in HepG2 cells, respectively.
Conclusion: The consumption of ahiflower oil improves the circulating levels of EPA and EPA-derived oxylipins in humans. In cultivated hepatocytes, EPA and EPA-derived oxylipins are more effectively increased by SDA than ALA.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2024 Seidel, Eberhardt, Wiebel, Luersen, Ipharraguerre, Haegele, Winterhalter, Bosy-Westphal, Schebb and Rimbach.)
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فهرسة مساهمة: Keywords: HepG2 cells; ahiflower oil; crossover-study; eicosanoids; oxylipins; taurine
تواريخ الأحداث: Date Created: 20240708 Latest Revision: 20240709
رمز التحديث: 20240709
مُعرف محوري في PubMed: PMC11225816
DOI: 10.3389/fnut.2024.1359958
PMID: 38974810
قاعدة البيانات: MEDLINE
الوصف
تدمد:2296-861X
DOI:10.3389/fnut.2024.1359958