دورية أكاديمية
أعرض في EDS

CircCDC42-encoded CDC42-165aa regulates macrophage pyroptosis in Klebsiella pneumoniae infection through Pyrin inflammasome activation.

التفاصيل البيبلوغرافية
العنوان: CircCDC42-encoded CDC42-165aa regulates macrophage pyroptosis in Klebsiella pneumoniae infection through Pyrin inflammasome activation.
المؤلفون: Xu N; Jiangsu Province Engineering Research Center of Cardiovascular Drugs Targeting Endothelial Cells, School of Life Sciences, Jiangsu Normal University, Xuzhou, China.; Laboratory of Morphology, Xuzhou Medical University, Xuzhou, China., Jiang J; Jiangsu Province Engineering Research Center of Cardiovascular Drugs Targeting Endothelial Cells, School of Life Sciences, Jiangsu Normal University, Xuzhou, China., Jiang F; Jiangsu Province Engineering Research Center of Cardiovascular Drugs Targeting Endothelial Cells, School of Life Sciences, Jiangsu Normal University, Xuzhou, China.; Department of Laboratory Medicine, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, China., Dong G; Jiangsu Province Engineering Research Center of Cardiovascular Drugs Targeting Endothelial Cells, School of Life Sciences, Jiangsu Normal University, Xuzhou, China.; Laboratory of Morphology, Xuzhou Medical University, Xuzhou, China., Meng L; Jiangsu Province Engineering Research Center of Cardiovascular Drugs Targeting Endothelial Cells, School of Life Sciences, Jiangsu Normal University, Xuzhou, China.; Laboratory of Morphology, Xuzhou Medical University, Xuzhou, China., Wang M; Jiangsu Province Engineering Research Center of Cardiovascular Drugs Targeting Endothelial Cells, School of Life Sciences, Jiangsu Normal University, Xuzhou, China.; Laboratory of Morphology, Xuzhou Medical University, Xuzhou, China., Chen J; Jiangsu Province Engineering Research Center of Cardiovascular Drugs Targeting Endothelial Cells, School of Life Sciences, Jiangsu Normal University, Xuzhou, China., Li C; Xuzhou Key Laboratory of Emergency Medicine, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, China., Shi Y; Jiangsu Province Engineering Research Center of Cardiovascular Drugs Targeting Endothelial Cells, School of Life Sciences, Jiangsu Normal University, Xuzhou, China. shiyongp@sina.com., He S; Department of Oncology, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, China. sisihe1219@163.com., Li R; Jiangsu Province Engineering Research Center of Cardiovascular Drugs Targeting Endothelial Cells, School of Life Sciences, Jiangsu Normal University, Xuzhou, China. lirongpeng@jsnu.edu.cn.
المصدر: Nature communications [Nat Commun] 2024 Jul 08; Vol. 15 (1), pp. 5730. Date of Electronic Publication: 2024 Jul 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: Pyroptosis*/genetics , Klebsiella pneumoniae* , Klebsiella Infections*/immunology , Klebsiella Infections*/microbiology , Klebsiella Infections*/metabolism , Inflammasomes*/metabolism , cdc42 GTP-Binding Protein*/metabolism , cdc42 GTP-Binding Protein*/genetics , Mice, Inbred C57BL*, Animals ; Mice ; Macrophages, Alveolar/metabolism ; Macrophages, Alveolar/immunology ; Macrophages, Alveolar/microbiology ; Male ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; Humans ; Immunity, Innate ; Macrophages/metabolism ; Macrophages/immunology ; Macrophages/microbiology ; CARD Signaling Adaptor Proteins
مستخلص: The circular RNA (circRNA) family is a group of endogenous non-coding RNAs (ncRNAs) that have critical functions in multiple physiological and pathological processes, including inflammation, cancer, and cardiovascular diseases. However, their roles in regulating innate immune responses remain unclear. Here, we define Cell division cycle 42 (CDC42)-165aa, a protein encoded by circRNA circCDC42, which is overexpressed in Klebsiella pneumoniae (KP)-infected alveolar macrophages. High levels of CDC42-165aa induces the hyperactivation of Pyrin inflammasomes and aggravates alveolar macrophage pyroptosis, while the inhibition of CDC42-165aa reduces lung injury in mice after KP infection by inhibiting Pyrin inflammasome-mediated pyroptosis. Overall, these results demonstrate that CDC42-165aa stimulates Pyrin inflammasome by inhibiting CDC42 GTPase activation and provides a potential clinical target for pathogenic bacterial infection in clinical practice.
(© 2024. The Author(s).)
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معلومات مُعتمدة: NSFC82270011 National Natural Science Foundation of China (National Science Foundation of China); Grant No. 2022(626) Natural Science Foundation of Guizhou Province (Guizhou Natural Science Foundation)
المشرفين على المادة: 0 (Inflammasomes)
EC 3.6.5.2 (cdc42 GTP-Binding Protein)
0 (NLR Family, Pyrin Domain-Containing 3 Protein)
0 (Cdc42 protein, mouse)
0 (Pycard protein, mouse)
0 (CARD Signaling Adaptor Proteins)
تواريخ الأحداث: Date Created: 20240708 Date Completed: 20240708 Latest Revision: 20240802
رمز التحديث: 20240802
مُعرف محوري في PubMed: PMC11231140
DOI: 10.1038/s41467-024-50154-x
PMID: 38977695
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/s41467-024-50154-x